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Chemotherapy is challenging for patients, as it can be terribly brutal on their bodies, but also for physicians trying to figure out which medication to deliver. Now, a new device has been developed at Rutgers University that can test whether a given chemo agent works on a patient's specific tumor. The idea is that a tumor biopsy is used to seed the device. Chemo agents are then added to see whether they kill the patient's tumor cells. This is measured using a special biosensor that relies on multifrequency impedance spectroscopy...
Dysfunction of the pancreas is related to a number of diseases, most famously diabetes. Conditions such as cystic fibrosis-related diabetes (CFRD), are particularly difficult to study in a laboratory setting, but researchers at Cincinnati Children’s Hospital Medical Center have now developed a device, and an accompanying methodology, to mimic the functionality of the human pancreas. The technology is already being used to answer important questions about how CFRD comes about and will certainly help in solving other medical mysteries. The team's microfluidic device has two chambers separated by a porous...
HER2 (human epidermal growth factor receptor 2) is a protein that is associated with some particularly aggressive forms of breast cancer. The presence of high concentrations of this protein seems to lead to the growth of tumors, so inactivating HER2 may help to stop the spread of certain strains of cancer in the body. An existing technique involves introducing an antibody that can block HER2 from binding to other things, but now researchers at Nanjing University in China have developed a polymer nanoparticle that can bind to HER2 just as...
iCAD, a company based in Nashua, New Hampshire, won European CE Mark approval for its ProFound AI for 2D Mammography software system. The product relies on a "high-functioning, deep learning" artificial intelligence algorithm to analyze 2D mammography scans and point out potential areas of concern. The software package provides "Certainty of Finding" and "Case Scores" for each instance of a suspect lesion that it identifies, helping radiologists better focus on what's important while quickening and improving the quality of diagnosis. The system works by noticing slight changes in soft tissue...
INSIGHTEC, an Israeli firm, and GE Healthcare have won FDA approval and the European CE mark for the Exablate Neuro with the SIGNA Premier MRI. The Exablate Neuro, made by INSIGHTEC, delivers focused ultrasound into the brain as a treatment option for tremor dominant Parkinson's disease, essential tremor, and neuropathic pain (the last indication appropriate only to Europe). This gives clinicians the ability to treat patients without penetrating the scalp and brain. The SIGNA Premier MRI, a 3.0 Tesla scanner from GE Healthcare, is used prior to the procedure to...
The development of new drugs is a long and tedious process. Chemists come up with new libraries of molecules which biologists test to see whether these generate some kind of cellular response. Promising agents become models for further chemical development, and the process continues repeatedly until promising candidates for animal trials are found. Researchers at the Karlsruhe Institute of Technology in Germany have now developed a chip that allows scientists to perform chemical synthesis and immediately follow up by testing the resulting compounds on live cells. The technology is fast...
Centerline Biomedical, a company based in Cleveland, Ohio, landed FDA clearance for its Intra-Operative Positioning System (IOPS). The product provides physicians with a radiation-free way to navigate through vasculature during minimally invasive procedures. Currently, X-ray fluoroscopy is used to track where minimally invasive instruments are in a patient's body. Danger results from ionizing radiation, but also from the low-resolution 2D grayscale images that clinicians have to work with. These can make it challenging to understand the location and position of instruments, often leading to long procedures, difficulty completing them, or...
The company received its FDA clearance in 2016 when it transformed the traditional urinary catheter into a smart sensing platform that helps to accurately monitor vital signs in real-time, such as urine output (UO) and intra-abdominal pressure (IAP). Traditional urinary catheters have issues draining urine from the bladder, causing inaccurate UO measurements. Using active drain line clearance, the Accuryn® Monitoring System automatically clears the drainage line as needed. Hayward, California - July 15, 2019 – Potrero Medical has received CE mark in the European Union for its technology platform, the...
Researchers at Tufts University and the Chinese Academy of Sciences have developed a new lipid nanoparticle which can deliver CRISPR/Cas9 gene editing tools into organs with high efficiency, suggesting that the system is promising for clinical applications. The CRISPR/Cas9 system is currently being investigated as a way to treat a variety of diseases with a genetic basis, including Duchenne muscular dystrophy, Huntington’s, and sickle cell disease. While the system has significant promise, there are some issues that need to be resolved before it can be used clinically. CRISPR/Cas9 is a...

July 15th, 2019 by Siavash Parkhideh
Researchers from Ecole Polytechnique Fédérale de Lausanne in Switzerland have developed new nanoparticles for theranostic (therapeutic and diagnostic) applications. Their work describes the synthesis of these particles and demonstrates that by stimulating at a long, safe wavelength, the nanoparticles can cleave bonds that hold onto drugs and release them into the body. This is an exciting development for the field of nanomedicine, and may one day lead to improved detection and treatment of many diseases, including cancer. Nanoparticles have been developed in the past for theranostic applications, but they tended...
Undergraduate researchers at John Hopkins University have developed a cryoablation probe for breast cancer, which uses carbon dioxide instead of argon, making it more affordable and accessible for use in low resource regions.   Treatments for women with breast cancer are scarce in poorer places. In fact, survival rates can be as low as 12% for breast cancer patients in places such as The Gambia, compared with 90% in the United States. Treatments that are commonly used in wealthier countries, such as surgery or chemotherapy, are either too expensive or...

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Medicine

Low Power Network for Wireless Body Sensors

As wearable devices multiply and gather ever more data about our bodies, the batteries and wireless networks they rely on can become strained. To give wearables a... July 19th, 2019

Cardiology

Low Power Network for Wireless Body Sensors

As wearable devices multiply and gather ever more data about our bodies, the batteries and wireless networks they rely on can become strained. To give wearables a... July 19th, 2019

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