The Global Hyaluronidase Market generated a valuation of US$ 778.37 million in 2022, and it is projected to reach a market valuation of US$ 1,894.03 million by 2031, growing at a compound annual growth rate (CAGR) of 9.3% during the forecast period from 2023 to 2031.
Global hyaluronidase market is witnessing tremendous growth during the forecast period. This progress can be due to the high prevalence of skin-related ailments and the increasing need for dermatological therapies. Additionally, hyaluronidase finds application in various medical fields, thereby bolstering the growth of the global market. Moreover, the supply of hyaluronidase is expanding as companies invest in research and development to introduce innovative and unique products to the market.
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The increasing prevalence of skin-related disorders and the growing demand for dermatological treatments are key drivers of market growth in the field of hyaluronidase. Skin conditions such as wrinkles, scars, hyperpigmentation, and acne have become common concerns among individuals worldwide. These conditions have led to a surge in the interest and use of hyaluronic acid (HA) and hyaluronidases (HYALs) for regulating the catabolism of HA and its molecular weight distribution in various tissues.
In line with this, hyaluronidase plays a significant role in dermatology and various medical applications. In the aesthetics market, hyaluronic acid-based dermal fillers, which often require hyaluronidase for their administration, are widely used. Hyaluronidase is licensed in the United Kingdom for enhancing the permeation of subcutaneous or intramuscular injections, local anesthetics, and subcutaneous infusions and promoting the resorption of excess fluids and blood.
Expanding Use of Hyaluronidase for Different Applications: A New Opportunites for the Market
The market growth is also being driven by its expanding applications in various medical procedures and drug delivery systems. Hyaluronidase is utilized to enhance the absorption and dispersion of injected drugs and fluids, making it valuable in fields such as ophthalmology, plastic surgery, and anesthesia. By breaking down hyaluronic acid, the enzyme enables better drug efficacy and improved patient outcomes in these applications.
Hyaluronidase is proving to be beneficial in enhancing the systemic delivery of injectable medications, leading to improved treatment outcomes for patients with chronic diseases. This enzyme has been shown to enhance the absorption and dispersion of injected drugs, making it valuable in various medical fields such as ophthalmology, plastic surgery, and anesthesia. By breaking down hyaluronic acid, hyaluronidase facilitates the better efficacy of injected medications and fluids.
For instance, in June 2023, Takeda announced the full results of a clinical trial investigating HYQVIA® [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] as maintenance therapy in adult patients with chronic inflammatory demyelinating polyneuropathy (CIDP) This highlights the growing interest in utilizing hyaluronidase to improve treatment outcomes in chronic disease management.
The expanding applications of hyaluronidase in drug-delivery systems are particularly noteworthy. As therapeutic modalities have evolved to include nucleic acids, peptides, proteins, and antibodies, innovative drug delivery technologies are needed to enhance their bioavailability and effectiveness hyaluronidase plays a role in improving the delivery of these therapeutic agents by enhancing their absorption and dispersion.
Dermatology: The Leading Application of Hyaluronidase
In 2022, dermatology contributed about US$ 302.34 million, making it the largest application segment. This dominance is likely to expand at a compound annual growth rate (CAGR) of 9.5% over the projection year.
Dermatology continues to rule the global hyaluronidase market due to improvements in dermatological therapies, rising demand for cosmetic operations, and rising prevalence of skin-related diseases.
According to NCBI, the number of cosmetic procedures performed in the hospital’s plastic, aesthetic, and reconstructive surgery department rose by 49.4% in 2021 compared to 2020 and by 29.7% compared to 2019. This growing figure highlights the demand for hyaluronidase, which is propelling the market expansion.
The International Society of Aesthetic Plastic Surgeons conducted a global survey on aesthetic procedures, and the results showed that both surgical and nonsurgical operations like liposuction, breast augmentation, rhinoplasty, botox, and fillers are at an all-time high in the world. Plastic surgeons performed thirty million aesthetic operations in 2021; 12.8 million of those procedures were surgical, and 17.6 million were nonsurgical. This is a 33 percent increase in aesthetic surgery in the previous four years.
This rising number signifies the continued dominance of dermatology in the global hyaluronidase market.
North America Accounted for US$ 306.13 Million Revenue of the Global Market
North America holds the largest share in the global hyaluronidase market, with a market value of over US$ 306.13 million in 2022. The United States and Canada are the primary contributors to this market in the region. In 2022, the United States accounted for approximately US$ 277 million, representing around 90% of the market share in North America. Canada also plays a significant role, contributing approximately $28.30 million to the hyaluronidase market in the same year.
Additionally, Canada is a major player in the North American hyaluronidase market. Hyaluronidase has become widely used in Canada due to the nation’s well-regulated healthcare system, growing demand for dermatological treatments, and increased disposable income. In addition, the country’s market demand has been further stimulated by the aging population and changing beauty standards.
According to the Canadian Dermatology Association, over half of all Canadians will experience various skin issues throughout their lifetime. These include conditions such as eczema (atopic dermatitis), acne, birthmarks, psoriasis, hair loss, vitiligo, molluscum, and warts, which are commonly observed in Canada. Skin cancers are also prevalent in the country, with cutaneous melanoma and non-melanoma skin cancer being the most common types. The Canadian Cancer Society estimated 6,800 new cases of cutaneous melanoma and 78,300 new cases of non-melanoma skin cancer in Canada. These skin conditions and the high incidence of skin cancers contribute to the revenue growth of the dermatological market in Canada. The increasing prevalence of these issues, coupled with the country’s aging population and evolving beauty standards, drives the demand for dermatological treatments and products in Canada.
The United States plays a significant role in driving the growth of the hyaluronidase market in North America. The country’s strong healthcare system, extensive research and development (R&D) activities, and a large consumer base seeking aesthetic treatments and dermatological procedures have propelled its dominance in the market. For example, in 2022, over 15 million minimally invasive cosmetic procedures were performed in the United States alone, according to the American Society of Plastic Surgeons, which has contributed to the increased demand for hyaluronidase in the country.
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Top Players in the Global Hyaluronidase Market
- Bausch & Lomb Incorporated
- McKesson
- Amphastar Pharmaceuticals Inc.
- Halozyme Inc.
- the Cooper Companies Inc.
- Sun Pharmaceutical Industries Ltd.
- STEMCELL Technologies Inc.
- Shreya Life Sciences Pvt. Ltd.
- Calzyme
- Dermax Medical Technology (Hebei) Co., Ltd.
- Shijiazhuang Yiang Technology Co., Ltd.
- Xiamen Vecon Int
- Other Prominent Players
Market Segmentation Overview:
By Type
- Animal Derived
- Synthetic
By Application
- Dermatology
- Chemotherapy
- Ophthalmology
- Plastic Surgery
- Others
By Region
- North America
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- The U.S.
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- Canada
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- Mexico
- Europe
- Western Europe
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- The UK
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- Germany
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- France
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- Italy
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- Spain
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- Rest of Western Europe
- Eastern Europe
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- Poland
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- Russia
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- Rest of Eastern Europe
- Asia Pacific
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- China
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- India
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- Japan
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- Australia & New Zealand
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- South Korea
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- ASEAN
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- Rest of Asia Pacific
- Middle East & Africa
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- Saudi Arabia
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- South Africa
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- UAE
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- Rest of MEA
- South America
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- Argentina
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- Brazil
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- Rest of South Americ
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