The surging demand for human biologics presents a challenge, as existing mammalian cell culture production platforms are both costly and limited in scalability. However, recent advancements in plant expression vectors, downstream processing, and glycoengineering have positioned plants as a superior alternative for biologics production. Plants not only offer conventional benefits like proper eukaryotic protein modification but also promise more cost-effective and scalable biologics production. They significantly enhance biologics output at an unprecedented rate while aiding in the control of potential pandemics, such as COVID-19, Ebola, and others, to improve efficacy and safety.
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Plant-based biologics are poised to become the next major breakthrough in biotechnology. Their advantages in terms of product safety, production scalability, cost-effectiveness, ease of storage, and distribution are unparalleled by current commercial systems. Furthermore, plant-based biologics open the door to providing affordable drugs and vaccines to emerging economies like Argentina, Brazil, China, India, Indonesia, Mexico, and more.
Impact of the Coronavirus (COVID-19) Pandemic on the Plant-Based Biologics Market
The rapid spread of COVID-19 has had a positive impact on the plant-based biologics market, increasing the demand for plant-based vaccines to combat the virus. The urgent need for novel diagnostics, therapeutics, and vaccines to combat the SARS-CoV-2 virus and prevent future outbreaks has spurred rapid development efforts. Developing safe and effective vaccine platforms is crucial for preparedness against future pandemics. Several vaccine technologies, including live or killed viruses and recombinant DNA or messenger RNA (mRNA) approaches, are being pursued by companies like iBio Inc. and PlantForm to address COVID-19. Major players like AstraZeneca, Pfizer, Moderna, and CureVac are accelerating vaccine development, with some already in late-stage clinical trials involving tens of thousands of participants.
The plant-based biologics market was valued at $19.4 million in 2020 and is projected to grow at a CAGR of 3.4% during the forecast period (2020-2027).
A Robust Pipeline of Plant-Based Biologics to Drive Market Growth
Key market players have multiple biopharmaceutical products in clinical trials or awaiting regulatory approval. This robust pipeline of biopharmaceutical products is expected to drive significant growth in the global plant-based biologics market. For instance, Protalix Biotherapeutics, a global plant-based biologics drug manufacturing company, has a major plant-based drug candidate, Pegunigalsidase alfa, in their pipeline. This drug is designed for the treatment of Fabry disease and is currently in phase 3 clinical trials.
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Additionally, iBio, Inc., a plant-based biologics manufacturer, has three plant-based biologics in the preclinical stage, including IBIO-100 targeting fibrosis, IBIO-200 as a COVID-19 virus-like particle vaccine, and IBIO-201 as a COVID-19 vaccine using the patented LicKM platform. These developments are expected to have a positive impact on the global plant-based biologics market growth.
Stringent Regulatory Guidelines and Environmental Concerns as Market Restraints
One of the major factors expected to hinder the growth of the plant-based biologics market is the stringent regulatory guidelines governing their production. Environmental concerns, including contamination risks, are another factor that could impede market growth. For example, ProdiGene, Inc. faced significant consequences when plant remnants from a previous trial contaminated a conventional field, resulting in substantial fines and bankruptcy. Such incidents can setback the commercial use of plant molecular farming (PMF).
Regional Analysis of the Plant-Based Biologics Market
The global plant-based biologics market is segmented into North America, Latin America, Europe, Asia Pacific, the Middle East, and Africa.
North America is poised to be the most lucrative region in the plant-based biologics market, thanks to the presence of numerous private and government research organizations focused on R&D for plant-based biologics. Latin America is also expected to witness substantial growth due to the establishment of manufacturing facilities for plant-based biologics, as seen in Brazil-based Axis Biotec Brasil’s construction of a facility for biosimilars and biobetter drugs.
Key players in the global plant-based biologics market include Leaf Expression Systems, Zea Biosciences, Planet Biotechnology Inc., InVitria, PlantForm Corporation, IBIO, Inc., Mapp Biopharmaceutical, Inc., Pfizer Inc., Ventria Bioscience Inc., Medicago Inc., Eleva GmbH, Kentucky Bioprocessing, LLC, Solarvest Bioenergy Inc., and Byondis B.V.
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Table of Contents with Major Points:
- Key Findings
- Definitions and Assumptions
- Definition of PLANT BASED BIOLOGICS MARKET
- Market Dynamics
- Trends and Developments
- Key Emerging Trends
- Key Developments Mergers and Acquisition
- New Product Launches and Collaboration
- Partnership and Joint Venture
- Latest Technological Advancements
- Insights on Regulatory Scenario
- Porters Five Forces Analysis
Qualitative Insights Impact of COVID-19 on Global PLANT BASED BIOLOGICS MARKET
- Supply Chain Challenges
- Steps taken by Government/Companies to overcome this impact
- Potential opportunities due to COVID-19 outbreak
- Data Sources
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