Bone grafting is a surgical method that involves replacing missing bone, and it employs various types of bone grafts, including synthetic bone graft, autologous bone graft, and allograft. The market growth of bone grafting procedures is anticipated to be fueled by the increasing utilization of bone graft substitutes like polymers, ceramics, bioactive glass, and others during the forecast period. Through technological advancements, the incorporation of human growth factors into bone grafts that have both osteoinductive and osteoconductive properties, like bone morphogenetic proteins, platelet-rich plasma (PRP), and demineralized bone matrix, is expected to create growth opportunities for market participants to establish a solid position in the global bone graft and substitutes market during the projected timeframe.
The main objective of researchers is to create groundbreaking bone grafts to address bone disorders. In 2015, Texas A&M University researchers pioneered a novel synthetic substance —a biodegradable scaffold—that can be used to fill the gaps and promote new bone growth. This innovative approach aims to enhance grafting treatments for individuals who require them to combat bone cancers or defects.
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The global bone graft and substitutes market growth is predicted to be driven by the rising incidence of bone cancer.
The increasing incidence of bone cancer is projected to drive the demand for bone grafts and substitutes, which will aid in the growth of the global bone graft and substitutes market in the coming years. The American Society of Clinical Oncology (ASCO) estimated that in 2017, about 3,450 individuals in the United States of all age groups were diagnosed with primary bone cancer. Hence, the rising number of new bone cancer cases is expected to boost the expansion of the bone cancer treatment market in the United States.
Additionally, the growth of the global bone graft and substitutes market during the projected timeframe is anticipated to be propelled by the adoption of strategies such as acquisitions by major industry players. An example of this is the acquisition of Xpand Biotechnology by Kuros Biosciences in 2016, which was done through a share swapping deal. Kuros Biosciences incorporated Xpand’s granular formulation, “MagnetOs,” to create innovative dental bone grafts. This acquisition is expected to result in substantial sales for Kuros in various regions, including Europe and the United States.
Leading companies
Leading companies, including Megagen, Ace Surgical Supply Co., Inc., Johnson & Johnson, NovaBone Product, LLC., Bone Therapeutics SA, Exactech, Inc., K2M Group Holdings, Inc., Medtronic Plc., OsteoNovus, LifeNet Health, ORTHOFIX INTERNATIONAL N.V., Zimmer Biomet Holdings, Inc., KYERON Medical Innovations, Stryker Corporation., OsteoMed LLC, BioHorizons Implant Systems, Inc., Institute Straumann AG, NuVasive, Inc., Globus Medical, Inc., Geistlich Pharma, Novadip Biosciences, RTI Surgical, Inc., Mesoblast Ltd., Alphatec Spine, Inc., are operating in the global bone graft and substitutes market.
Recent Developments
- OSTEOAMP SELECT Fiber, an allograft substitute for the bone injuries in the spine, foot, and ankle, was released by Bioventus in March 2019. These fibers are specifically designed to retain essential growth factors that promote bone growth and provide pathways for cell migration. In cases where bones are broken and voids are formed, OSTEOAMP SELECT Fibers can be used to facilitate bone fusion.
- Medtronic introduced Grafton, a Demineralized Bone Matrix (DBM) product, in February 2019 for orthopedic procedures, particularly for the spine bones. Grafton possesses a high degree of osteoinductivity, a vital factor for bone fusion. It serves as a bone graft extender, substitute, and filler for voids within the skeletal system.
- In 2018, Actifuse Flow, a bone graft substitute manufactured by Baxter International Inc., was granted approval by the US Food and Drug Administration (FDA) for use in orthopedic surgeries. This product is designed to promote accelerated bone growth and comes in a packaged delivery injection that allows for precise placement of the graft substitute into small gaps or voids within affected bones.
- NovaBone Products Pvt. Ltd. introduced two new additions to its bone graft substitute collection in 2017, namely NovaBone IRM and the IRM MacroPOR. These products are designed to enhance osteoblastic and osteogenesis activity at the site of application.
- Citagenix, Inc., expanded its range of PentOS OI bone grafts by introducing PentOS OI Max in 2017, designed specifically for oral and maxillofacial surgery. The product is composed of a collagen matrix that has inductive properties and can be combined with stem cells and blood components obtained from patients.
- Anika Therapeutics, Inc. obtained clearance through a 510(k) process from the US Food and Drug Administration (FDA) in 2017 for its bone void filler containing hyaluronic acid. This product is intended for the repair of skeletal defects and is composed of biocompatible materials that function as a synthetic and bone graft substitute. The bone void filler is placed in the void and hardens at body temperature, and during the healing process, it is gradually absorbed and substituted by new bone growth.
The Global Bone Graft Substitutes Market was worth 2,586.30 Million in 2022 and is projected to grow at a CAGR of 4.5% between 2023 and 2030.
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| The market size value in 2023 |
Restraints
The use of bone grafting surgeries has offered vital treatment options for many patients with different bone conditions. However, the anticipated risks of surgical and graft failure are likely to impede market growth during the projected period. Dental-Implants-01 reports that, on average, dental bone grafts have failure rates ranging from 5–10% due to infections and inadequate stabilization of the grafts. Consequently, the inability to successfully implant grafts is anticipated to obstruct the expansion of the global bone graft and substitutes market during the projected duration.
Classification of the global bone graft and substitutes market
Based on the type of product:
- Bone Grafts
- Xenografts
- Allografts
- Bone Graft Substitutes
- Composites
- Demineralized Bone Matrix
- Ceramics
- Bone Morphogenetic Proteins
- Polymers
- Others
Based on the type of application
- Dental Bone Grafts
- Joint Reconstruction
- Oncology
- Spinal Fusion
- Craniomaxillofacial
- Trauma & Extremities
Based on the type of region
- Africa
- Latin America
- Asia Pacific
- The Middle East
- Europe
- North America
Regional Analysis
The global bone graft and substitutes market is divided into different regions, including Africa, Latin America, Asia Pacific, North America, Europe, and the Middle East.
During the projected timeframe, North America is predicted to maintain its dominant position in the global bone graft and substitutes market due to several factors, including the advancements in bone grafting technology and the production of bone grafts and substitutes by major players in the region. For example, Artoss, Inc., a U.S.-based company has incorporated nanobiology and nanotechnology in the manufacturing of synthetic bone grafts. NanoBone granules were introduced by the company in 2015, followed by NanoBone SFX putty in 2016. In addition, several US-based companies such as Thermo Fisher Scientific Inc., EverlyWell, Inc., Lactation Lab, and OmegaQuant LLC, offer a variety of bone graft and substitutes in the North American market.
The global bone graft and substitutes market is anticipated to experience substantial growth in Europe in the foreseeable future. This can be attributed to the increasing number of implant surgeries being carried out in various European nations, which is likely to fuel the demand for bone graft and substitutes in the region. As an example, Meddevicetracker reported that Europe had performed more than 56,000 shoulder arthroplasty surgeries in 2015. Furthermore, the latest bone grafts have proven to provide enhanced clinical outcomes, thereby reducing complications.
The Asia Pacific region is projected to experience noteworthy growth in the global bone graft and substitutes market, primarily due to the efforts made by nations like Japan, India, and China to create innovative bone graft products and alternatives. An example of this is the National Chemical Laboratory in Pune, India, which introduced PoroSyn and SynOst (bioactive synthetic bone graft granules and putty) in May 2017, which are intended to repair and regenerate bones that have been lost as a result of accidents, illnesses, or injuries.
Table of Contents with Major Points:
Executive Summary
- Introduction
- Key Findings
- Recommendations
- Definitions and Assumptions
Executive Summary
Market Overview
- Definition of Bone Graft Substitutes Market
- Market Dynamics
- Drivers
- Restraints
- Opportunities
- Trends and Developments
Key Insights
- Key Emerging Trends
- Key Developments Mergers and Acquisition
- New Product Launches and Collaboration
- Partnership and Joint Venture
- Latest Technological Advancements
- Insights on Regulatory Scenario
- Porters Five Forces Analysis
Qualitative Insights Impact of COVID-19 on Global Bone Graft Substitutes Market
- Supply Chain Challenges
- Steps taken by Government/Companies to overcome this impact
- Potential opportunities due to COVID-19 outbreak
Conclusion
Appendix
- Data Sources
- Abbreviations
- Disclaimer
TOC Continued…!
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