Due to rising demand for personalized medicine, effective drug discovery, and an increase in the prevalence of chronic diseases, the global organoids and spheroids market is anticipated to experience significant growth, with a CAGR of 22.42%, reaching a valuation of US$ 4,567.0 Million by 2031, up from US$ 771.4 Million in 2022.
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Spheroids and organoids are both 3D-shaped structures made of cultivated cells. Organoids are a complicated assemblage of cells with a particular organ focus, primarily from the bladder, liver, and stomach. These are made of stem or progenitor cells, which, when given a scaffolding environment, may self-assemble themselves. From there, they develop into miniature replicas of the host organ and are excellent for 3D cell investigations. Spheroids are formed from tissues such as tumors, mammary glands, hepatocytes, and embryoid bodies, as opposed to organoids, which may self-assemble into 3D cultures without the need for scaffolding.
The adoption of organoids in research is due to the use of organoid models to demonstrate how the COVID-19 virus affects a number of intestinal cells. Researchers to identify and evaluate potential treatments are using these technologies. Products are being developed and released by businesses far in advance of the COVID-19 pandemic. Using a Seahorse XF analyzer, Agilent Technologies, for instance, has created a spheroid microplate that makes it easier to monitor the cellular energy metabolism in 3D cell culture spheroids. The business’s Seahorse XFe96 Spheroid Microplates are used to track respiration and glycolysis in 3D cell cultures. In a similar vein, Corning Incorporated introduced spheroid microplates and HTS Transwell tissue culture systems for high-throughput culturing.
The use of organoids as therapeutic tools, their use in drug discovery and personalized medicine, and their usage in research and development are all predicted to drive the global organoids market. Chronic and infectious disease incidence and prevalence are likely to rise. The use of organoids as a crucial tool for cell biology, gene therapy, regenerative medicine, cancer research, and disease modeling is driving the global market.
Technological advances are likely to drive the worldwide organoids market. For instance, Hubrecht Organoid Technology and JSR Corporation partnered strategically in 2019 to deliver preclinical oncology drug development services utilizing organoid technology and increase their footprint in Europe by creating a new operational center in the Netherlands focusing on organoid research.
Geographical Outlook
By 2031, the Asia Pacific region revenue is likely to increase from 23% to over 28%, making it the second-largest market after the United States. The predicted expansion is the result of advancements in medical advances, particularly in the field of stem research, supported by significant market collaborations. Nichirei Biosciences, established in Japan, and UPM struck a partnership deal in March 2020 to distribute the latter’s cultural products in Japan. The agreement made it possible for the organoid culture’s essential raw ingredients to be available.
North America dominated the organoids and spheroids market, recording a revenue share of 40%. This is due to the existence of significant market participants, beneficial government initiatives, and rising research activity in the area. The region can now offer a wide range of cutting-edge organoid and spheroid technologies, significantly improving its market position, thanks to the significant presence of businesses like Thermo Fisher Scientific and STEMCELL Technologies.
Segmentation Overview
In terms of Type, the Organoids segment Leads the Global Market
The organoids segment is likely to contribute more than 53% of the global organoids and spheroids industry revenue. The use of organoids in drug development, disease modeling, and customized treatment is on the rise, which explains this. Organoids are three-dimensional constructs made from stem cells that can use to represent a patient’s illness and aid in the creation of individualized therapy regimens.
In terms of Application, the Developmental Biology Segment is Likely to Grow at the Highest Rate:
The developmental biology segment is likely to record a revenue share of 33% of the organoids and spheroids industry. This is because there is a rising need for organoids and spheroids to investigate tissue regeneration and organ development. Organoids and spheroids are being used to replicate intricate developmental processes like organogenesis, which can offer important insights into the mechanisms underlying developmental disorders. Developmental biology is a discipline that is continually growing.
In terms of End-User, the Pharmaceutical and Biotechnology Segment is Estimated to Account highest Revenue Share:
By 2031, the pharmaceutical and biotechnology sector segment is likely to account for more than 50% of the revenue share in the global organoids and spheroids market. This is because chronic diseases are becoming more common, and there is a growing need for efficient and effective drug discovery. New treatments and therapies for chronic diseases like cancer, diabetes, and heart disease are being developed using organoids and spheroids.
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Competitive Landscape
The top five players in the market for organoids and spheroids control more than 48% of the total revenue. With a revenue share of over 17%, Thermo Fisher Scientific, the market leader, rules the roost. Other significant market players are Merck KGaA, Corning Incorporated, and Lonza Group AG.
The market’s intense rivalry encourages product development and innovation, which may result in price competitiveness and prohibitively high entry barriers for new firms.
In Oct 2022, AIM Biotech, a Singapore- and Boston-based business introduced the organiX System, a lab tool to closely replicate human disease by adding vascularization and immunological competence to organoids, spheroids, and tumor biopsies.
In Jan 2021, Molecular Devices, LLC, a major supplier of high-performance life science equipment, unveiled the next-generation, high-content imaging system on a global scale. The ImageXpress® Confocal HT.ai High-Content Imaging System, which builds on the success of the company’s flagship model, is intended to assist researchers in advancing the phenotypic screening of 3D organoid models.
In March 2020, the complete line of UPM cell culture products is now available to researchers in Japan due to a collaboration between UPM Biomedicals and Nichirei Biosciences Inc.
Major Players
- 3D BioMatrix
- 3D Biotek LLC
- AMS Biotechnology (Europe) Limited
- ATCC
- Cellesce Ltd
- Corning Incorporated
- Greiner Bio-One
- Hubrecht Organoid Technology (HUB)
- InSphero/Perkin Elmer
- Kuraray
- Lonza
- Merck KGaA
- Prellis Biologics
- STEMCELL Technologies Inc.
- Thermo Fisher Scientific, Inc.
- Other Prominent Players.
Segmentation Outline
By Type
- Organoids
- Neural Organoids
- Hepatic Organoids
- Intestinal Organoids
- Kidney Organoids
- Other Organoids
- Spheroids
- Multicellular tumor spheroids (MCTS)
- Neurospheres
- Mammospheres
- Hepatospheres
- Embryoid bodies
By Method
- Organoids
- General Submerged Method for Organoid Culture
- Crypt Organoid Culture Techniques
- Air Liquid Interface (ALI) Method for Organoid Culture
- Clonal Organoids from Lgr5+ Cells
- Brain and Retina Organoid Formation Protocol
- Spheroids
- Micropatterned Plates
- Low Cell Attachment Plates
- Hanging Drop Method
- Others
By Source
- Organoids
- Primary Tissues
- Stem Cells
- Spheroids
- Cell Line
- Primary Cell
- iPSCs Derived Cell
By Application
- Developmental Biology
- Personalized Medicine
- Regenerative Medicine
- Disease Pathology Studies
- Drug Toxicity & Efficacy Testing
By End User
- Biotechnology and pharmaceutical industries
- Academic & Research Institutes
- Hospitals and diagnostic centers
By Region
- North America
- The U.S.
- Canada
- Mexico
- Europe
- Western Europe
- The UK
- Germany
- France
- Italy
- Spain
- Rest of Western Europe
- Eastern Europe
- Poland
- Russia
- Rest of Eastern Europe
- Asia Pacific
- China
- India
- Japan
- Australia & New Zealand
- South Korea
- ASEAN
- Rest of Asia Pacific
- Middle East & Africa (MEA)
- Saudi Arabia
- South Africa
- UAE
- Rest of MEA
- South America
- Argentina
- Brazil
- Rest of South America
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