E2 enzymes, also known as ubiquitin enzymes or ubiquitin-carrier enzymes, play a critical role in the ubiquitination process. This process involves tagging a protein with ubiquitin, a short protein consisting of 76 amino acids, in order to target it for degradation by the proteasome. E2 enzymes facilitate the second step of this process by attaching the ubiquitin molecule to a lysine residue on the target protein. Once a protein is tagged with a single ubiquitin molecule, multiple rounds of ubiquitination can occur, resulting in the formation of a polyubiquitin chain that is recognized by the 19S regulatory subunit of the proteasome.
Ubiquitin Enzyme will not only profit big pharma companies but also small to mid-sized players and academic institutions.
Numerous global studies and research groups are exploring the complex regulatory structure to advance viable drug compounds. Since 2015, nearly 1500 journals related to ubiquitin enzymes have been published in a short span of one year. The advancements in ubiquitin enzymes have led to the development of various technological platforms, essential tools, chemicals, and pioneering compounds, which aid in drug discovery programs in academic and industry research. These trend-lines from literature studies show that not only big pharma giants, but also small to mid-sized players and academic institutions are involved in this field.
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In the Ubiquitin Enzymes Market, there have been numerous strategic partnerships formed to advance research and development processes. This growing field of research has attracted the attention of venture capital firms and investors. The market, with a primary focus on cancer indications, is expected to thrive in the long run, leading to the emergence of several successful drugs.
Over the projected period, the cancer under application segment will lead the market for ubiquitin enzymes.
The Ubiquitin Enzymes Industry is categorized based on product type, application and geography. The product type segment is further sub-categorized into E1 and E2 enzymes as therapeutic targets, E3 enzymes as therapeutic targets, dub enzymes as therapeutic targets and associated drug class. The application segment includes cancer, biological engineering and other related areas.
Pharmaceutical companies are being pushed to invest more in ubiquitin enzyme research due to a rise in clinical trial success rates.
Coherent Market Insights’ regional segmentation of the ubiquitin enzymes market includes North America, Europe, Asia Pacific, Latin America, Middle East, and Africa. The largest market share is held by North America, which can be attributed to the high number of research centers and the presence of global pharma players that develop protein molecules for therapeutic activities.
The development of the ubiquitin enzyme market is anticipated to be aided by the more than 40 clinical trial molecules in development.
The global ubiquitin enzymes market is home to key players such as Abbiotec, 3SBio, Abcam, 5AM Ventures, AcelRx Pharmaceuticals, Aegera Therapeutics, Agilis Biotherapeutics, Aeneas Ventures, Aileron Therapeutics, Alexion Pharmaceuticals, and Amgen, among others. These players are focused on research and development to tap into the largely untapped market, which presents significant growth opportunities. Over 45 molecules are currently under development as ubiquitin pathway-based inhibitors to treat a range of indications. The high incidence of cancer globally is expected to boost the growth of the ubiquitin enzymes market in the coming years. The regional market is segmented into North America, Europe, Asia Pacific, Latin America, the Middle East, and Africa, with North America leading the market due to the presence of numerous research centers and global pharma players engaged in developing protein molecules for therapeutic activities.
The market growth of ubiquitin enzymes is expected to be fueled by ongoing research and development activities. For instance, in March 2019, a team of researchers from Sungkyunkwan University School of Medicine reported that small molecules binding to ubiquitin and suppressing the ubiquitin pathway can increase the sensitivity of cancer cells to doxorubicin.
In November 2018, researchers from Institut national de la recherche agronomique found that Ubiquitin-conjugating enzyme E2 E1 is primarily expressed in the cytoplasm of slow-twitch fibers and can protect skeletal muscles from exacerbated atrophy caused by dexamethasone treatment.
In March 2018, a group of researchers from the Chinese Academy of Tropical Agricultural Sciences identified 40 putative ubiquitin-conjugating enzyme genes, which were grouped into 15 categories based on a phylogenetic analysis.
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Table of Content
Chapter 1 Industry Overview
1.3 Research Scope
1.4 Market Analysis by Regions
1.5 Ubiquitin Enzymes Market Size Analysis from 2023 to 2030
11.6 COVID-19 Outbreak: Ubiquitin Enzymes Industry Impact
Chapter 2 Global Ubiquitin Enzymes Competition by Types, Applications, and Top Regions and Countries
2.1 Global Ubiquitin Enzymes (Volume and Value) by Type
2.3 Global Ubiquitin Enzymes (Volume and Value) by Regions
Chapter 3 Production Market Analysis
3.1 Global Production Market Analysis
3.2 Regional Production Market Analysis
Chapter 4 Global Ubiquitin Enzymes Sales, Consumption, Export, Import by Regions (2017-2023)
Chapter 5 North America Ubiquitin Enzymes Market Analysis
Chapter 6 East Asia Ubiquitin Enzymes Market Analysis
Chapter 7 Europe Ubiquitin Enzymes Market Analysis
Chapter 8 South Asia Ubiquitin Enzymes Market Analysis
Chapter 9 Southeast Asia Ubiquitin Enzymes Market Analysis
Chapter 10 Middle East Ubiquitin Enzymes Market Analysis
Chapter 11 Africa Ubiquitin Enzymes Market Analysis
Chapter 12 Oceania Ubiquitin Enzymes Market Analysis
Chapter 13 South America Ubiquitin Enzymes Market Analysis
Chapter 14 Company Profiles and Key Figures in Ubiquitin Enzymes Business
Chapter 15 Global Ubiquitin Enzymes Market Forecast (2023-2030)
Chapter 16 Conclusions
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