Epigenetics is the study of heritable changes in gene function that do not involve changes to the underlying DNA sequence. It refers to modifications to the DNA molecule or to the proteins and other molecules that interact with DNA, that result in changes to gene expression or activity, without altering the DNA sequence itself. These modifications can be influenced by environmental factors and can result in long-term changes to an organism’s phenotype.
What is the market size of epigenetics?
According to the report published by Allied Market Research, the global epigenetics market was estimated at $1.0 billion in 2020 and is expected to hit $4.1 billion by 2030.
- CAGR: 14.8%
- Current Market Size: USD 1.0 Billion
- Forecast Growing Region: APAC
- Largest Market: North America
- Projection Time: 2020– 2030
- Base Year: 2019
- Report Key Pointer: COVID-19 Outbreak & Impact
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High-end technological advancements associated with epigenetics, rise in incidences of cancer, surge in genome mapping programs, and growing number of R&D activities drive the global epigenetics market. On the other hand, standardization concerns over epigenetics-based diagnostics and dearth of skilled professionals impede the growth to some extent. However, several growth opportunities in the emerging economies have created an array of lucrative prospects for the key players in the industry.
In epigenetics, various segments of the genome can be studied, including:
- Chromatin: The complex of DNA and proteins that make up chromosomes and play a key role in regulating gene expression.
- DNA methylation: The addition of a methyl group to the DNA molecule, which can alter the way genes are regulated.
- Histone modification: Changes to the proteins around which DNA is wrapped, affecting the accessibility of the DNA to the cellular machinery that transcribes genes into RNA.
- Non-coding RNA molecules: Small RNA molecules that regulate gene expression by interacting with DNA or other RNA molecules.
These segments are all targets for epigenetic modifications, and each can contribute to the regulation of gene expression and the determination of cellular phenotypes.
- Rise in number of epigenetic researches and increase in awareness of epigenetic drugs for the treatment of coronavirus infection has had a positive impact on the global epigenetics market.
- This drift is most likely to continue till the pandemic is completely over.
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Genetics and epigenetics are two distinct fields of study in the life sciences, although they are closely related.
Genetics refers to the study of the DNA sequence and how it determines the traits and characteristics of an organism. It focuses on the inheritance of traits from parents to offspring and the variation in DNA sequences among individuals in a population.
Epigenetics, on the other hand, focuses on the heritable changes in gene function that do not involve changes to the underlying DNA sequence. Instead, epigenetics is concerned with the changes in gene activity and expression that result from modifications to the DNA molecule or to the proteins and other molecules that interact with DNA. These modifications can be influenced by environmental factors and can result in long-term changes to an organism’s phenotype.
In short, genetics is concerned with the sequence of DNA, while epigenetics is concerned with the regulation of gene expression and activity based on modifications to the DNA molecule and its environment.
Epigenetics is a rapidly advancing field, and new innovations are constantly being developed. Some of the recent innovations in the field of epigenetics include:
- CRISPR-mediated epigenome editing: Using the powerful CRISPR gene editing system to make precise modifications to the epigenome, such as DNA methylation or histone modification, with the goal of correcting genetic diseases.
- Epigenetic reprogramming: Developing methods to reverse or reset the epigenetic marks on cells, with applications in regenerative medicine and cancer therapy.
- Epigenetic biomarkers: Developing new methods to identify and measure epigenetic changes in cells and tissues, with potential applications in disease diagnosis and prognosis.
- Epigenetic inheritance: Discovering the mechanisms by which epigenetic changes can be transmitted from one generation to the next, with implications for understanding the role of epigenetics in evolution and disease.
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By Regional Analysis:
The market across North America dominated in 2020, garnering nearly of the global epigenetics market, owing to rapid adoption of advanced technologies and presence of key players across North America. Simultaneously, Asia-Pacific is expected to cite the fastest CAGR of 16.3% throughout the forecast period, due to rise in R & D activities for epigenetics services and increase in healthcare investment in the region.
Key players in the industry-
- Abcam Plc.
- PerkinElmer, Inc.
- Zymo Research
- QIAGEN N.V.
- Merck Millipore
- Agilent Technologies, Inc.
- Illumina Inc.
- Active Motif, Inc.
- Hologic Inc.
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About Allied Market Research:
Allied Market Research (AMR) is a full-service market research and business-consulting wing of Allied Analytics LLP based in Portland, Oregon. Allied Market Research provides global enterprises as well as medium and small businesses with unmatched quality of “Market Research Reports” and “Business Intelligence Solutions.” AMR has a targeted view to provide business insights and consulting to assist its clients to make strategic business decisions and achieve sustainable growth in their respective market domains. AMR offers its services across 11 industry verticals including Life Sciences, Consumer Goods, Materials & Chemicals, Construction & Manufacturing, Food & Beverages, Energy & Power, Semiconductor & Electronics, Automotive & Transportation, ICT & Media, Aerospace & Defense, and BFSI.