In short, immunosuppressants are drugs that suppress the immune system to prevent organ rejection in transplantation and treat autoimmune diseases such as myasthenia gravis, arthritis, lupus, rheumatoid arthritis, Crohn’s disease, etc. They work by blocking the immune response and protecting the transplanted organ. The use of immunosuppressants is divided into three phases: induction, maintenance, and treatment of acute rejection.
The immunosuppressant industry involves the production and sale of drugs that suppress or weaken the immune system. These drugs are used primarily in the treatment of autoimmune diseases, such as rheumatoid arthritis and psoriasis, as well as to prevent rejection of transplanted organs. The immunosuppressants market size was valued at $13.89 billion in 2018 and is expected to grow to $42.51 billion by 2026, with a CAGR of 14.7% from 2019 to 2026.
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Some of the key players in the immunosuppressant market include :
AbbVie Inc., Astellas Pharma Inc., Bristol-Myers Squibb Company, GlaxoSmithKline Plc., INTAS PHARMACEUTICALS LTD. (Accord Healthcare Ltd.), Johnson & Johnson (Janssen Pharmaceuticals, Inc.), Mylan N.V., Novartis International AG (Sandoz), Pfizer Inc., Sanofi S.A.
The immunosuppressant market is segmented by region into North America, Europe, Asia-Pacific, and the rest of the world.
North America is one of the largest markets for immunosuppressants, driven by factors such as high incidence of autoimmune diseases, growing demand for organ transplantation, and the presence of major pharmaceutical companies in the region.
Europe is also a significant market for immunosuppressants, with countries such as Germany and the UK being major contributors to the market. The market in Europe is expected to grow due to the increasing aging population and the high demand for organ transplantation.
The Asia-Pacific region is expected to be the fastest-growing market for immunosuppressants, driven by factors such as the growing elderly population, increasing incidence of autoimmune diseases, and the growing demand for organ transplantation in countries such as China and India.
The rest of the world includes Latin America, the Middle East, and Africa, and is expected to experience moderate growth in the immunosuppressant market due to factors such as increasing healthcare expenditure and the growing demand for organ transplantation.
The immunosuppressant market can be segmented by indication into organ transplantation, autoimmune disorders, and other diseases.
Organ transplantation is the largest indication for immunosuppressants, accounting for the largest share of the market. This is due to the increasing number of organ transplantations being performed globally and the need to prevent organ rejection.
Autoimmune disorders is the second largest indication for immunosuppressants, driven by the increasing incidence of autoimmune diseases such as rheumatoid arthritis, psoriasis, and multiple sclerosis.
Other diseases where immunosuppressants are used include inflammatory bowel disease, lupus, and cancer. These indications are expected to show moderate growth in the immunosuppressant market.
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The immunosuppressant market is mainly used for the treatment of three indications:
- Organ transplantation – to prevent rejection of transplanted organs.
- Autoimmune disorders – to suppress overactive immune response in diseases like rheumatoid arthritis, lupus, etc.
- Other diseases – such as psoriasis, Crohn’s disease, and others where immune suppression is required to control the disease progression.
The immunosuppressant market can be segmented by drug class into:
- Calcineurin Inhibitors – e.g. Tacrolimus and Cyclosporine
- Corticosteroids – e.g. Prednisone and Methylprednisolone
- Monoclonal Antibodies (mAbs) – e.g. Basiliximab and Daclizumab
- mTOR Inhibitors – e.g. Sirolimus and Everolimus
- Other Immunosuppressants – e.g. Azathioprine, Mycophenolate mofetil, and others.
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