A genetic disorder known as Hutchinson-Gilford progeria syndrome is characterised by the quick, dramatic onset of ageing starting in childhood. A mutation in the lamin A (LMNA) gene is the root cause of Hutchinson-Gilford progeria syndrome. The affected youngsters encounter facial features like projecting ears, small chins, large eyes, narrow lips, and thin noses with beaked tips. Additionally, this illness results in baldness, irregularities of the joints, aging-looking skin, and a loss of fat beneath the skin (subcutaneous fat). Additionally, Hutchinson-Gilford progeria syndrome patients begin to have severe arterial stiffening (arteriosclerosis) as early as childhood. Age-related deterioration of the illness raises the risk of heart attack or stroke even in young people.
According to the National Institutes of Health, Hutchinson-Gilford progeria is an uncommon illness that affects one in every four million infants worldwide (NIH). According to NIH statistics, more than 130 instances have so far been documented. The affected patients have a maximum life expectancy of 30 years and a median life expectancy of 13 years. Nearly 90% of patients pass away as a result of atherosclerosis-related complications. Hutchinson-Gilford progeria syndrome has not yet had a viable treatment therapy discovered as of 2012. The existing treatments primarily aimed to lessen growth anomalies and cardiovascular problems.
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Farnesyltransferase Inhibitor (FTI)
The first clinical trial for the farnesyltransferase inhibitor (FTI) Lonafarnib, which is used to treat children with Hutchinson-Gilford progeria syndrome, had promising results in 2012. According to clinical trial findings, progeria patients’ weight gain, bone mineral density, vascular stiffness, and sensorineural hearing all improved. Growth hormone and sulforaphane treatments from the past helped to lessen the symptoms and extend a child’s life. But it’s critical that the patient sees the cardiologist on a frequent basis. Another medication that has been utilised in the past is rapamycin, which has been shown to stop nuclear blebbing, delay cellular senescence, and speed up progerin breakdown.
In 2015, researchers at the Agency for Science, Technology & Research (ASTAR) produced a Hutchinson-Gilford progeria syndrome model with success. This organization’s work put up a paradigm that suggests progerin and telomeres are related. Telomeres in the cell become more brittle and vulnerable to damage as a result of progerin’s induction of a decrease in heterochromatin, a kind of DNA that is tightly packed. In turn, the harmed telomeres bring to early cellular ageing. The nucleus was distorted as a result of the progerin gene, decreasing cells’ capacity to divide and proliferate, according to this concept, which is drastically different from the one previously accepted. The nuclear envelope becomes unstable as a result of the altered progerin protein, which also gradually harms the nucleus and increases the risk of cell death.
Researchers are trying to figure out how genetic variations contribute to the Hutchinson-Gilford progeria syndrome’s distinctive traits. This condition will be treated more effectively with the help of ongoing research advancements and greater understanding of human ageing.
Major institutions’ efforts to create new treatments for age-related illnesses are predicted to present profitable potential for market players. In August 2019, for example, researchers at the Houston Methodist Research Institute at the Texas Medical Center are concentrating on employing RNA therapeutics—treatment that emphasises on ribonucleic acids, a molecule found in all living cells—to slow and possibly reverse Hutchinson-Gilford Progeria.
Similar findings were made in July 2019 by researchers from the University of Oviedo in Spain, who discovered that faecal microbiota transplants can extend the lives of mice who have aged too soon. The study could aid in developing specialised probiotic treatments for age-related illnesses like Hutchinson-Gilford Progeria in people.
Additionally, in March 2019, scientists from the Universidad de Oviedo and Centro Nacional de Investigaciones Cardiovasculares (CNIC) discovered a brand-new molecular pathway that contributes to the early development of atherosclerosis in mice with Hutchinson-Gilford progeria syndrome. Progeria’s early atherosclerosis can be prevented by using the recently discovered therapeutic target.
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Table of Content
Chapter 1 Industry Overview
1.3 Research Scope
1.4 Market Analysis by Regions
1.5 Medical Claims Processing Services Market Size Analysis from 2023 to 2030
11.6 COVID-19 Outbreak: Medical Claims Processing Services Industry Impact
Chapter 2 Global Medical Claims Processing Services Competition by Types, Applications, and Top Regions and Countries
2.1 Global Medical Claims Processing Services (Volume and Value) by Type
2.3 Global Medical Claims Processing Services (Volume and Value) by Regions
Chapter 3 Production Market Analysis
3.1 Global Production Market Analysis
3.2 Regional Production Market Analysis
Chapter 4 Global Medical Claims Processing Services Sales, Consumption, Export, Import by Regions (2017-2022)
Chapter 5 North America Medical Claims Processing Services Market Analysis
Chapter 6 East Asia Medical Claims Processing Services Market Analysis
Chapter 7 Europe Medical Claims Processing Services Market Analysis
Chapter 8 South Asia Medical Claims Processing Services Market Analysis
Chapter 9 Southeast Asia Medical Claims Processing Services Market Analysis
Chapter 10 Middle East Medical Claims Processing Services Market Analysis
Chapter 11 Africa Medical Claims Processing Services Market Analysis
Chapter 12 Oceania Medical Claims Processing Services Market Analysis
Chapter 13 South America Medical Claims Processing Services Market Analysis
Chapter 14 Company Profiles and Key Figures in Medical Claims Processing Services Business
Chapter 15 Global Medical Claims Processing Services Market Forecast (2023-2030)
Chapter 16 Conclusions
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