Size exclusion-based chromatography is known as gel permeation chromatography. It is primarily often employed to ascertain the polymer’s molecular weight distribution, which verifies the purity of the analyte. Several analyte components are also separated based on how well they adhere to stationary phase. Depending on the analyte and packing material of the column, aqueous as well as non-aqueous mobile phases are utilised in gel permeation chromatography. You can employ a range of detectors, including those that measure concentration, provide information on the size and structure of analytes, measure light scattering, measure refractive index, and use a viscometer.
“Gel Permeation Chromatography Market is expected to reach US$ 2,268.9 million by 2030 from US$ 1,304.4 in 2022; it is estimated to grow at a CAGR of 7.2%from 2023 to 2030. The report highlights trends prevailing in the global Gel Permeation Chromatography market, and drivers and hindrances pertaining to the market growth.
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Market expansion is anticipated to be aided by an increased emphasis on R&D (research & development) efforts by biotech and pharmaceutical businesses throughout the world that target long-lasting diseases like cancer to introduce novel therapies for their treatment. These are protein-based (natural polymer) treatments, including immunological check point inhibitors, CAR-T cell therapy, and antibody-drug conjugates. In 2017, the International Federation of Pharmaceutical Manufacturers and Associations published a report stating that biotech and pharmaceutical firms based on research spend over US$ 149 bn yearly on R&D (research and development) worldwide. There are currently more than 7,000 compounds being studied for therapeutic development, with about 2,000 of those being prospects for treating cancer. Thus, gel permeation chromatography effectively enables the separation and characterization of novel chemical entities that are polymer-based, and this is anticipated to support market expansion within the next year. Additionally, the majority of these medications are in preclinical research, which involves examining the structure and elements of novel chemical entities and necessitates the use of a gel permeation chromatography device.
To create a range of dosage forms for the medications, biotech and pharmaceutical businesses often use polymers as excipients (Binder, coating agents, Diluent, , suspending agents, Disintegrants, and viscosity agents). Owing to its inertness, relatively inexpensive, and increased consumer acceptance of natural polymers, natural polymers are being used rather than synthetic ones. Newly released natural polymers include Solutol HS 15, Kollicoat Smartseal 30 D, Soluplus, , Prosolv ODT and Polyplasdone Ultra from various manufacturers. Though , end users (biotechnology and pharmaceutical businesses) must have faith in the purity of polymers for use as excipients before utilising them in formulation. The formulations must be manufactured according to US Food and Drug Administration (US FDA) requirements for Quality by Design else non-adherence otherwise leads to product recalls. Companies must thus classify these polymers according to quality standards. GPC systems must be effective for this. The International Council for Harmonization (ICH) recommendation (M4Q), which mandates that innovative excipients characterise their functioning and physicochemistry, must also be followed by businesses. For example, the National Center for Biotechnology Information asserted in October 2019 that ethylcellulose is a medicinal excipient having multidirectional applications in the formulation of drug dosage forms and use a gel permeation chromatography system as an analysis approach.
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The disease has extended to more than 100 nations ever since COVID-19 viral epidemic in December 2019, and on 30th January, 2020, the World Health Organization proclaimed it to be a public health emergency.
Three key ways in which COVID-19 has impacted the economy are by directly influencing drug demand and manufacturing as well as by causing distribution channel interruptions. Many nations, including China, Saudi Arabia, Egypt, India, the United Arab Emirates, and others, are having difficulty moving pharmaceuticals from one location to another as a result of nationwide lockdowns.
On the other hand, the pandemic of COVID-19 pandemi had a favourable effect on the market for gel permeation chromatography worldwide. Polymers utilised in coating cloth were identified, measured, and detected using the technique of GPC (gel permeation chromatography). For example, on 11th February, 2022, researchers at the University of British Columbia developed a non-toxic, enviromentally polymer coating for hospital materials that lowered COVID-19-causing virus infectivity by almost 90%.
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In accordance with a Royal Society of Chemistry article from September 2020, Water Advanced Polymer Chromatography (APC) technology is well supported by GPC (gel permeation chromatography), gel permeation elution chromatography (GPEC), and hydrophilic interaction liquid chromatography (HILIC) for raising the level of research sophistication and enhancing flexibility for the analysis of complicated polymer blends.
The expensive cost of the GPC (gel permeation chromatography) system and its components, which restricts the application of the instrument in academic institutes with the exception of pharmaceutical organizations, is one of the main issues impeding the expansion of the world market for this technology. Owing to the increasingly widespread use of other analytical tools like Liquid Chromatography-Mass Spectrometry (LC-MS), which has several applications including characterization, analysis, detection, and quantification, the market for gel permeation chromatography is anticipated to grow more slowly.
The main companies functioning in the market for GPC (gel permeation chromatography) worldwide are Agilent Technologies, Waters Corporation, Malvern Panalytical, Shimadzu Corporation, Polymer Char, Tosoh Corporation, Gilson, Inc., and Thermo Fisher Corporation.
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