Congenital Hyperinsulinism Treatment Market to Surpass US$ 319.9 Mn and is expected to exhibit a CAGR of 5.7% during the forecast period | Zealand Pharma A/S, Eli Lilly and Company, Xeris Pharmaceuticals, Inc

The market for treatments for congenital hyperinsulinism is anticipated to rise as a result of prominent industry players’ increased R&D efforts. For instance, in September 2022, the biotechnology company Zealand Pharma A/S released the clinical findings from the dasiglucagon phase 3 trial for the treatment of congenital hyperinsulinism in babies. In order to prevent hypoglycemia in newly diagnosed children with congenital hyperinsulinism, research was done on chronic dasiglucagon infusion. A glucagon analogue that can be administered with a long-term subcutaneous infusion is dasiglucagon. Dasiglucagon was given the orphan medication classification for the treatment of CHI in 2017 by both the European Commission and the U.S. Food and Drug Administration (FDA).

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Impact

The financial standing of companies in all industries, including the private healthcare sector, has been harmed by the COVID-19 epidemic and lockdowns in numerous nations throughout the world. One area where the COVID-19 epidemic has had a big influence is private healthcare.

The COVID-19 pandemic, however, had a negative effect on the market for treating congenital hyperinsulinism because fewer cases of the condition were diagnosed and there was less information available on the condition’s medications and patients. For instance, the COVID-19 epidemic affected information on the long-term outcomes of persons with diabetes, according to statistics provided by the American Diabetes Association in October 2021. Given that we are still in the midst of a global COVID-19 epidemic, it is anticipated that an even greater number of people worldwide may develop new-onset hyperinsulinism in association with new-onset diabetes brought on by SARS-CoV-2 infection. Numerous endocrine illnesses, including diabetes, hypertension, and hyperinsulinism, as well as the financial opportunities for their treatments, had been adversely affected by the epidemic. The steps taken to stop the spread of COVID-19 also had a negative effect on supply interruption. Essential medicines for endocrinal disorders were hard to come by as a result of the COVID-19 pandemic’s impact on global trade.

Key Developments

New approach Congenital hyperinsulinism has been successfully diagnosed using 18F-6-fluoro-l-dopa PET/CT imaging. For instance, the new approach 18F-6-Fluoro-l-Dopa PET/CT Imaging for therapy has shown promising results in the detection of congenital hyperinsulinism, according to data published by the National Center for the biotechnology information in July 2021. In these studies on congenital hyperinsulinism treatment, 18F-6-Fluoro-l-Dopa PET/CT Imaging has been found to be the most reliable method for locating and detecting hyperinsulinism focal lesions. It is also said to be a safe method that has been accepted as standard of care in HI cases with a suspected focal lesion.

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Key Takeaways

The market for treatments for congenital hyperinsulinism is anticipated to grow at a CAGR of 5.7% over the course of the projected period as a result of increased market leaders’ R&D efforts. Rezolute, Inc., a biopharmaceutical company, for instance, announced positive Phase 2 data for RZ358, a medication for congenital hyperinsulinism, in July 2022. Candidate RZ358 is an intravenously injected human monoclonal antibody that binds to an exclusive location (allosteric) on the insulin receptor throughout the body in a clinical trial investigation. The antibody alters how insulin binds to cells and signals to keep blood sugar levels within a normal range, counteracting the negative consequences of increased insulin levels.

In the global congenital hyperinsulinism treatment, the diazoxide segment is believed to occupy a dominant position among medication types. Following treatment, patients are essentially functional, which contributes to the regular generation and secretion of insulin.

Due to increased research and development for congenital hyperinsulinism by the main players, North America is anticipated to hold the biggest market share among regions in the global market for congenital hyperinsulinism treatments over the forecast period. For instance, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health announced in February 2021 that pharmaceutical company Crinetics Pharmaceuticals, Inc. would continue to receive funding under its Small Business Innovation Research (SBIR) grant of up to approximately US$ 0.9 million (NIH). The money is being used to further ongoing studies and the creation of Crinetics’ nonpeptide somatostatin agonists for congenital hyperinsulinism (CHI). The NIDDK has granted the company funding of about US$ 2.2 million under award number R44DK115290.

Teva Pharmaceutical Industries Ltd., Eli Lilly and Company, USV Private Limited, Xeris Pharmaceuticals, Inc., Amphaster Pharmaceuticals, Inc., Rezolute, Inc., Novo Nordisk A/S, Hanmi Pharm.Co., Ltd., e5 Pharma,LLC, Fresenius Kabi AG, Jolly Healthcare, Eiger BioPharmaceuticals, AmideBio,LLC, and Crinetics Pharmaceuticals, Inc., are significant market participants.