Low-molecular-weight substances that are able to detect, treat, and/or prevent illnesses are known as small molecule medicines. The majority of small molecule medications may be taken orally and can pass through cell membranes to target intracellular sites, giving them some specific benefits as treatments. Aspirin, diphenhydramine, and other compounds found in people’s medicine cabinets are examples of small-molecule medications. Small molecule medications provide formidable tools for tackling experimentally difficult host-pathogen interaction issues and locating fresh prospective therapeutic targets. Small molecule medications can be created using leads obtained from natural resources or via rational drug design.
Market Statistics
By the end of 2022, the value of the worldwide small molecule drug discovery market is anticipated to reach US$ 46,883.1 Mn.
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Drivers
The worldwide small molecule drug discovery market is anticipated to rise during the projected period as a result of increased attention on the development of small molecule pharmaceuticals due to expansion in the demand for small molecule therapeutics. For instance, the demand for small molecule medications is rising quickly along with the global burden of disease. Small Molecule Drug Discovery Solution, a comprehensive scientific R&D platform with pre-configured processes and enhanced data management capabilities, will be on sale in July 2022, according to a Dotmatics announcement. Utilizing the company’s 15+ years of expertise and best practises, the new solution facilitates innovation for businesses.
Opportunities
Players in the small molecule drug discovery market should have tremendous development prospects due to the rising prevalence of chronic illnesses worldwide. Small compounds, for instance, can be utilised as anticancer medications to block specific proteins in cancer cells in innovative cancer treatments. In the treatment of cancer, more than 20 small molecule medications have been given clinical approval and are now being utilised. The National Cancer Institute claims that one of the top causes of mortality in the globe is cancer. In 2040, it is anticipated that there would be 16.4 million cancer-related deaths and 29.5 million new instances of cancer annually.
Restraints
The worldwide small molecule drug discovery market is predicted to experience growth challenges due to factors such as high drug development costs and strict rules and regulations. For instance, the search for small molecule drugs can be difficult and complex. The Center for Drug Evaluation and Research (CDER) of the FDA works to ensure that the American public has access to safe and efficient medications. The U.S. Food and Medication Administration (FDA) keeps an eye on drug manufacturers’ compliance with the FDA’s current good manufacturing practises (CGMP) guidelines in order to safeguard the quality of medicines.
Impact
Pharmaceutical firms and health systems all over the world are concentrating on finding small molecule medications to treat COVID-19 by looking at innovative and current pharmaceuticals for their capacity to lessen symptoms and stop viral replication. Several small molecule medications have so far demonstrated positive outcomes in clinical and preclinical studies. Additionally, scientists are concentrating on designing/developing peptide- and small-molecule-based antiviral medicines against a variety of targets of the SARS-CoV-2 viral illness. This is thus anticipated to contribute to the expansion of the market for small molecule drug discovery.
Key Takeaways
The market for small molecule drug discovery was estimated at US$ 43,571.6 Mn in 2021 and is anticipated to grow at a CAGR of 8.1% from 2022 to 2028 to reach US$ 74,672.5 Mn.
Oncology had a prominent position among therapeutic areas in the worldwide small molecule drug discovery market in 2021, accounting for 30.8% of the market’s value share. Increasing product approval and launch is anticipated to fuel segment expansion over the course of the forecast period.
Market Trends
The worldwide small molecule drug discovery market is anticipated to expand as a result of an increase in demand for small molecule medications on a global scale. For instance, to assist more creative pharmaceutical businesses swiftly find small molecule medications, BioDuro-Sundia and X-Chem developed DNA Encoded Compound Library (DEL) technology services in China in August 2022.
The worldwide small molecule drug discovery market is anticipated to develop over the course of the forecast period as a result of the frequent approval of small molecule medications. For instance, Tenaya Therapeutics reported in September 2022 that the U.S. Food and Drug Administration had approved its Investigational New Drug (IND) application to start clinical testing of TN-301 (FDA). Histone deacetylase 6 has a very specific small molecule inhibitor made by Tenaya called TN-301.
Competitive Landscape
Takeda Pharmaceutical Industries Ltd., Pfizer Inc., Novartis, Teva Pharmaceuticals, 21st Century Therapeutics Inc., Merck KgaA, Bristol-Myers Squibb Company, Johnson & Johnson, Boehringer Ingelheim GmbH, GlaxoSmithKline PLC, 4SC AG, Gilead Sciences Inc., AstraZeneca, Acacia Pharma Gr, and Immunocure Inc., are a few notable companies that compete in the global small molecule drug discovery market.
Recent Developments
The post-approval required clinical study examining the effects of BARHEMSYS (amisulpride injectable) in people with severe renal impairment was announced by Acacia Pharma Group in December 2021.
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Immunocure revealed in November 2020 that it can now synthesise the tiny compounds that clients choose or create during the early stages of medication research. This brand-new component of the system could make it easier for clients to get active chemicals.
The National Institutes of Health awarded 21st Century Therapeutics Inc. an SBIR research grant of USD 345 000 in December 2018 for the creation of a new small molecule that will serve as a radioprotector for total body irradiation.
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Table of Contents:
- Research Objectives and Assumptions
- Research Objectives
- Assumptions
- Abbreviations
- Market Purview
- Report Description
- Market Definition and Scope
- Executive Summary
- Market Snapshot, By Therapeutic Area
- Market Snapshot, By Process/Phase
- Market Snapshot, By Geography
- Coherent Opportunity Map (COM)
- Report Description
- Market Dynamics, Regulations, and Trends Analysis
- Market Dynamics
- Increasing prevalence of chronic diseases worldwide
- Stringent regulations and high cost of drug development
- Rise in demand for small molecule drugs worldwide
- Impact Analysis
- Key Highlights
- Regulatory Scenario
- Product launch/Approvals
- PEST Analysis
- PORTER’s Analysis
- Merger and Acquisition Scenario
- Market Dynamics
- Global Small Molecule Drug Discovery Market – Impact of Coronavirus (Covid-19) Pandemic
- COVID-19 Epidemiology
- Supply Side and Demand Side Analysis
- Economic Impact
- Global Small Molecule Drug Discovery Market, By Therapeutic Area, 2017-2028, (US$ Mn)
- Introduction
- Market Share Analysis, 2022 and 2028 (%)
- Y-o-Y Growth Analysis, 2017 – 2028
- Segment Trends
- Oncology
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2017-2028,(US$ Mn)
- Central Nervous System
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2017-2028,(US$ Mn)
- Cardiovascular
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2017-2028,(US$ Mn)
- Respiratory
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2017-2028,(US$ Mn)
- Metabolic Disorders
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2017-2028,(US$ Mn)
- Gastrointestinal
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2017-2028,(US$ Mn)
- Other Therapeutic Areas
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2017-2028,(US$ Mn)
- Introduction
- Global Small Molecule Drug Discovery Market, By Process/Phase, 2017-2028, (US$ Mn)
- Introduction
- Market Share Analysis, 2022 and 2028 (%)
- Y-o-Y Growth Analysis, 2017 – 2028
- Segment Trends
- Target ID/Validation
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2017-2028,(US$ Mn)
- Hit Generation and Selection
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2017-2028,(US$ Mn)
- Lead Identification
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2017-2028,(US$ Mn)
- Lead Optimization
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2017-2028,(US$ Mn)
- Introduction
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