Small Molecule Drug Discovery Market
The market for small molecule drug discovery was estimated at US$ 43,571.6 Mn in 2021 and is anticipated to grow at a CAGR of 8.1% from 2022 to 2028 to reach US$ 74,672.5 Mn. Due to the rising illness burden and expanding elderly population throughout the world, the worldwide small molecule drug discovery industry is expanding rapidly. Additionally, it is anticipated that increased demand for small molecule pharmaceuticals or other small molecules would accelerate market expansion. The expansion of the worldwide small molecule drug discovery market, however, is anticipated to be constrained by factors such the high cost of drug development and rigorous regulations.
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Regional Insights
The market for small molecule drug discovery is divided into five regions based on geography: North America, Latin America, Europe, Asia Pacific, and the Middle East & Africa.
Due to the increased prevalence of numerous chronic diseases, including cancer and cardiovascular disease, in this area, North America is predicted to have the biggest market share among all other regions during the course of the projection period. After heart disease, cancer continues to be the second most prevalent cause of death in the United States. For instance, the American Cancer Society predicts that there will be 1.9 million new instances of cancer and 609,360 cancer-related deaths in the United States in 2022, or nearly 1,670 fatalities each day.
In addition, due to greater investments in drug discovery, Asia Pacific is anticipated to have strong growth in the global small molecule drug discovery market. For instance, the Indian pharmaceutical sector is attempting to climb the global pharmaceutical value chain by investing in R&D for medication development, according to the India Brand Equity Foundation (IBEF). Lupin spent the most on research and development in FY20, followed by Dr. Reddy’s. Market Drivers
Over the course of the projection period, it is anticipated that the prevalence of chronic illnesses, such as cancer, cardiovascular disease, and others, would rise across the world. The World Health Organization (WHO) estimates that noncommunicable diseases (NCDs) account for 41 million annual deaths, or 71% of all fatalities globally. The majority of NCD fatalities (17.9 million per year) are caused by cardiovascular diseases, followed by malignancies (9.3 million), respiratory illnesses (4.1 million), and diabetes (1.5 million).
Over the course of the forecast period, an increase in research and development efforts by industry participants is anticipated to boost market expansion for small molecule drug discovery. For instance, Amgen and Arrakis Therapeutics inked a research agreement in January 2022 to collaborate on the discovery and development of therapeutic RNA degraders against a variety of challenging-to-drug targets across different therapeutic fields. Small-molecule medications that selectively eliminate RNAs encoding disease-causing proteins by bringing them close to nucleases make up this new family of targeted RNA degraders.
Market Opportunities
The worldwide small molecule drug discovery market is anticipated to provide attractive development prospects due to the increase in demand for small molecule medications. For instance, in August 2022, BioDuro-Sundia and X-Chem announced jointly that DNA Encoded Compound Library (DEL) technology services will be made available in China to assist global pharma firms in finding new small molecule medications more swiftly. Over 250 billion tiny compounds may be found in X-libraries, Chem’s a leader in DEL technology.
Players in the small molecule drug discovery market should see considerable growth prospects as the number of contract research and development firms grows. For instance, PPD Inc. announced its growth by constructing a new multifunctional clinical research laboratory in Suzhou, China, in October 2020. This facility will provide bioanalytical, biomarker, and vaccination services.
Market Trends
The worldwide small molecule drug discovery market is anticipated to develop as small molecule medications receive more regulatory approval. For instance, the Center for Drug Evaluation and Research (CDER) of the Food and Drug Administration (FDA) authorised 53 novel therapies in 2020, 38 of which were small molecules.
The worldwide small molecule drug discovery market is anticipated to rise as attention on small molecule drug discovery increases. For instance, the artificial intelligence (AI) company X-Chem declared in April 2022 that their XD3 drug discovery platform was now accessible to clients and partners in the biopharma industry. The end-to-end platform was created to assist small molecule firms in hastening the development of novel medications.
Market Restraints
The worldwide small molecule drug discovery market is predicted to experience growth challenges due to strict rules and regulations. For instance, CDER is in charge of guaranteeing the effectiveness and safety of drugs supplied in the US. Through its office of testing and research, CDER does a small amount of research on the efficacy, safety, and quality of medications. Additionally, the FDA ensures that medication producers follow its current good manufacturing practises (CGMP) regulations in order to preserve the quality of pharmaceutical goods.
The worldwide small molecule drug discovery market’s growth is anticipated to be constrained by the high cost of medication development. For example, estimates of the typical R&D expenditure for a new treatment range from less than US$ 1 billion to more than US$ 2 billion per drug in recent research. Thus, it is anticipated that the market’s expansion would be constrained by the greater costs of medication development.
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Market Segmentation
The Therapeutic Area, Process/Phase, and Region categories are used to categorise the worldwide small molecule drug discovery market research.
The oncology, central nervous system, cardiovascular, respiratory, metabolic disorders, gastrointestinal, and other therapeutic areas are the subsectors of the worldwide small molecule drug discovery market, respectively. Due to the increasing prevalence of cancer throughout the world, the oncology segment is predicted to dominate the market over the course of the projected period. The first small-molecule targeted medication with approval for three cancer indications is sorafenib (kidney cancer, liver cancer, and differentiated thyroid cancer).
Because cardiovascular disease is becoming more prevalent in the world, the cardiovascular segment is also anticipated to experience considerable increase in the near future. The main cause of mortality in the globe is cardiovascular disease. Cardiovascular disorders are being often treated using a variety of small compounds.
The market is divided into Target ID/Validation, Hit Generation & Selection, Lead Identification, and Lead Optimization based on Process/Phase. Out of these, the Target ID/Validation Segment is anticipated to lead the market throughout the course of the forecast period, and this development in medicines for therapeutic use is to blame.
Key Developments
The pivotal study required by the Food and Drug Administration (FDA) to investigate the use of Byfavo (remimazolam injectable) in the mild sedation of paediatric patients was launched by Acacia Pharma Group PLC in September 2021.
A cooperation between Regeneron Pharmaceuticals Inc. and AstraZeneca was established in June 2021 with the goal of researching, creating, and marketing small molecule medications that are aimed against the GPR75 target and have the potential to treat obesity and its associated co-morbidities.
In order to investigate biomarker-driven pre-operative administration of Domatinostat, Nivolumab, and Ipilimumab TURANDOT in Stage II–III Resectable Urothelial Cancer, 4SC and Netherlands Cancer Institute (NKI) started a second collaborative cooperation in June 2021.
Key Companies Insights
The search for new small molecule drugs is a fiercely competitive industry. This is explained by the increase in demand for small molecules or small molecule medications; as a result, market participants are concentrating on introducing innovative goods.
Key players
In addition to others, these companies include Takeda Pharmaceutical Industries Ltd.. Pfizer Inc., Novartis, Teva Pharmaceuticals, 21st Century Therapeutics Inc., Merck KgaA, Bristol-Myers Squibb Company, Johnson & Johnson, Boehringer Ingelheim GmbH, GlaxoSmithKline PLC, 4SC AG, Gilead Sciences Inc., Acacia Pharma Gr., AstraZeneca, and Immunocure Inc.
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Table of Contents:
- Research Objectives and Assumptions
- Research Objectives
- Assumptions
- Abbreviations
- Market Purview
- Report Description
- Market Definition and Scope
- Executive Summary
- Market Snapshot, By Therapeutic Area
- Market Snapshot, By Process/Phase
- Market Snapshot, By Geography
- Coherent Opportunity Map (COM)
- Report Description
- Market Dynamics, Regulations, and Trends Analysis
- Market Dynamics
- Increasing prevalence of chronic diseases worldwide
- Stringent regulations and high cost of drug development
- Rise in demand for small molecule drugs worldwide
- Impact Analysis
- Key Highlights
- Regulatory Scenario
- Product launch/Approvals
- PEST Analysis
- PORTER’s Analysis
- Merger and Acquisition Scenario
- Market Dynamics
- Global Small Molecule Drug Discovery Market – Impact of Coronavirus (Covid-19) Pandemic
- COVID-19 Epidemiology
- Supply Side and Demand Side Analysis
- Economic Impact
- Global Small Molecule Drug Discovery Market, By Therapeutic Area, 2017-2028, (US$ Mn)
- Introduction
- Market Share Analysis, 2022 and 2028 (%)
- Y-o-Y Growth Analysis, 2017 – 2028
- Segment Trends
- Oncology
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2017-2028,(US$ Mn)
- Central Nervous System
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2017-2028,(US$ Mn)
- Cardiovascular
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2017-2028,(US$ Mn)
- Respiratory
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2017-2028,(US$ Mn)
- Metabolic Disorders
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2017-2028,(US$ Mn)
- Gastrointestinal
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2017-2028,(US$ Mn)
- Other Therapeutic Areas
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2017-2028,(US$ Mn)
- Introduction
- Global Small Molecule Drug Discovery Market, By Process/Phase, 2017-2028, (US$ Mn)
- Introduction
- Market Share Analysis, 2022 and 2028 (%)
- Y-o-Y Growth Analysis, 2017 – 2028
- Segment Trends
- Target ID/Validation
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2017-2028,(US$ Mn)
- Hit Generation and Selection
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2017-2028,(US$ Mn)
- Lead Identification
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2017-2028,(US$ Mn)
- Lead Optimization
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2017-2028,(US$ Mn)
- Introduction
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