According to the study undertaken by Astute Analytica, the Europe Dental Bone Grafts and Substitutes Market is predicted to grow with a compound annual growth rate of 6.9% during the forecast year 2022-2030; and the market has been estimated to reach US$ 435.66 Mn by the end of the year 2030. A dental bone graft is a process that increases the amount of bone in the jaw area where the bone has been lost or additional support is required. Increased frequency of musculoskeletal disorders, the development of biocompatible synthetic bone grafts, and increased demand for oral bone grafts are some of the factors responsible for the market’s growth. The volume and density of the jaw can be increased in areas of bone loss through a dental bone graft. The bone graft material might be obtained from a patient’s own body (autogenous), and can be sourced from a human tissue bank (allograft) or from the animal tissue bank (xenograft). In some cases, the bone graft material may be synthetic (alloplast). To help the bone grow and accelerate wound healing, bone grafts are utilized as a filler and scaffold. These grafts have no antigen-antibody response, they are bioresorbable and serve as a mineral store that helps to stimulate the growth of new bone. The global dental membrane and bone graft substitutes market is anticipated to be driven by an increase in demand for better dental procedures owing to an increase in the number of dental problems among patients. Companies in the global dental membrane and bone graft replacements market are focusing on R&D in new materials and product innovation to increase their revenue. Additionally, the growing use of biomaterials in bone grafting treatments and the popularity of resorbable dental membranes are opening value-grab opportunities for companies producing alternatives to dental bone grafts.
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Dental bone graft substitutes are increasingly being used for implant operations in Europe as dentists become more aware of their advantages and simplicity and people are more concerned about their appearance and beauty. For instance, as per a survey, 40% of the population in the UK is disappointed with the appearance of their teeth and 49% of them are considering cosmetic dental implant treatment.
Market Dynamics:
The high prevalence of periodontal diseases is driving up demand for procedures using dental membranes and bone substitutes. With approximately 3.5 billion people worldwide, oral disorders are a significant health burden for many nations, according to the WHO. These include gum disease, oral cancer, dental caries, and ortho-dental trauma, among others. As a result, dental care expenses have dramatically increased.
The use of bone graft substitutes for dental implant insertion and bone support would increase soon as the number of dental implant surgeries increased. Due to an increase in the occurrence of various oral disorders and injuries, there are more dental implant treatments being performed, which is accelerating the market growth during the forecast period.
Moreover, the rising demand for medical and dental tourism in developing countries is a key driver in the dental bone graft substitute market. According to estimates, dental tourism makes up 42% of all medical travel worldwide and is steadily growing. The top three countries for dental tourists are Mexico, India, and Hungary. Mexico receives 25% of all dental tourists from throughout the world. While India treats predominantly Asian patients and some US people, Hungary primarily serves Europeans. Dental offices in various European nations charge inexpensive fees while maintaining a high degree of service quality. For instance, dental implants in Poland cost around US$ 600 in Poland and almost US$ 4,000 in the UK. The general pricing structure and residents’ typical living wages account for Europe’s low cost of dental care.
Restraints:
One of the factors restraining the market growth is the high cost of dental bone graft surgeries. The average cost of a dental bone graft is about US$ 300 to US$ 3,000 per graft. This will vary depending on the type of graft your dental surgeon uses, the duration of the surgery, and the amount of pre-existing bone mass in your jaw. Natural bone grafts have gradually been supplanted with synthetic bone replacements as grafting technology has advanced.
The development of hybrid grafts that use growth factors and living osteogenic cells capable of triggering bone regeneration represents the future of dental bone grafting. All these variables raise the cost of grafting surgery, making it a market impediment. The procedure complexity and material used in the grafting process are major cost-influencing factors. When bone graft material is sourced from a synthetic substance, animal, or cadaver, the cost can vary from US$ 400 to US$ 1,200. If bone material is harvested from the patient’s body, the cost may jump to more than US$ 2,000. Only autologous bone, as opposed to bone substitute and composite materials, combines osteoconductive, osteoinductive, and osteogenic properties among the various augmentation materials that are currently available. Autologous bone grafts have been regarded as the “gold standard” and most efficient material in bone regeneration treatments due to their characteristics and lack of immunological reactions.
Segmental Analysis
Type Insights:
On the basis of type, the dental bone graft substitutes market has been divided into two categories, PCR-based assays and ELISA-based assays which the latter has been estimated to grow with the highest CAGR of 7.7%. The ELISA (Enzyme-linked immunosorbent assay) is a screening test used for detecting antigens and/or antibodies against pathogens in inpatient Serum/ Plasma. As compared to PCR Assays, they are more sensitive and specific since they use Enzyme substrate reactions. However, PCR-based assays are still used for studying gene expression of bone and inflammation markers.
Product Insights:
Based on product, the dental bone graft substitute market is segmented into xenograft, allograft, autograft, and synthetic material, in which autograft is dominating the market in 2021 and has been estimated to grow with an annual growth rate of 7.5% during the forecast year. The quick availability, absence of disease transmission risk, and affordability of autologous bone are all significant benefits. The iliac crest is a popular source for cortical and cancellous transplants. The fibula can also be used to extract cortical bone.
In 2021, the market for dental bone graft substitutes has the second largest share in the synthetic bone grafts industry. The variety of synthetic graft possibilities has grown because of rising technological breakthroughs. Synthetic grafts have the advantages of easy availability, longer shelf life, lower morbidity, sterile and reduces the risk of disease transmission.
Treatment Type Insights:
Based on treatment type, synthetic bone graft substitutes share the highest portion of the market in 2021 owing to their good biocompatibility and similar chemical components to natural bone. It has good bone conductivity and similar mechanical strength to cancellous bone. Synthetic bone grafts are commonly used within orthopedics to provide a bone void filler that resorbs and is replaced with bone during the healing process. It has emerged as a promising technology in reconstruction, especially in the sports industry.
Application Insights:
The main application of bone grafting is in the clinical field. They are used in clinical trials, bone reconstruction, clinical research, tissue engineering, microbiology, etc. A bone substitute substance called AlgiPore, a naturally occurring hydroxyapatite (HA) generated from sea algae has been used in clinical settings. Following tooth extraction, AlgiPore has mostly been used in clinical treatment as a space filler in combination with other materials to prevent ridge abnormalities.
End User Insights:
Based on end-users, a contract manufacturing organization is leading the dental bone graft substitute industry in 2021 accounting for approximately 44% of the total market share alone. They assist in the combined development and production of biologic products. They essentially assist in the production of implants and instruments according to specifications. A lot of significant commercial and public companies hire contract manufacturing firms to create and manufacture customized implants, regenerative implants, etc.
Competitive Insights:
- The GalvoSurge Dental Implant Cleaning System from Nobel Biocare was introduced in October 2021 and completely removes biofilm from titanium implants that have been contaminated by microorganisms. It removes biofilm from difficult-to-reach areas on any titanium implant surface with bacterial contamination.
- In January 2021, Dentsply Sirona announced the acquisition of Datum Dental, Ltd. and its broad array of OSSIX biomaterials. Israel-based Datum Dental is renowned for its cutting-edge dental regeneration solutions that include the GLYMATRIX unique technology, which is clinically superior.
- In 2018, Institut Straumann AG purchased a 30% share in botiss biomaterials, a significant German supplier of goods for oral tissue regeneration. With this investment, the company was able to strengthen its alliance, acquire access to Botiss’ technology, and widen its botiss product distribution network globally.
- Through the acquisition of a 100% stake in Implant Direct, Danaher Corporation developed a strong foothold in the market for dental membrane and bone graft substitutes in 2017.
Segmentation Overview
The following are the various segments of the Europe Dental Bone Graft & Substitute Market:
By Type segment of the Europe Dental Bone Graft & Substitute Market is sub-segmented into:
PCR-based Assays
ELISA-based Assays
By Product segment of the Europe Dental Bone Graft & Substitute Market is sub-segmented into:
Xenograft
Autograft
Allograft
Synthetic analysis
By Treatment Type segment of the Europe Dental Bone Graft & Substitute Market is sub-segmented into:
Natural bone grafts
- Autologous bone grafts
- Cancellous autografts
- Cortical autografts
- Allogeneic bone grafts
- Cancellous allografts
- Demineralized bone matrix (DBM)
Synthetic bone graft substitutes
- Calcium sulfate
- Calcium phosphate ceramics (CaP ceramics)
- Tricalcium phosphate (TCP)
- Biphasic calcium phosphate (BCP)
- Calcium phosphate cement (CPC)
- Others
By Application segment of the Europe Dental Bone Graft & Substitute Market is sub-segmented into:
Research & Development
Clinical Applications
By End User segment of the Europe Dental Bone Graft & Substitute Market is sub-segmented into:
Biopharmaceutical Companies
Contract Research Organizations
Contract Manufacturing Organizations
Academic & Research Institutes
By Region segment of the Europe Dental Bone Graft & Substitute Market is sub-segmented into:
Western Europe
- The UK
- Germany
- France
- Italy
- Spain
- Rest of Western Europe
Eastern Europe
- Poland
- Russia
- Rest of Eastern Europe
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