“𝐈𝐧 𝐭𝐨𝐝𝐚𝐲’𝐬 𝐜𝐨𝐦𝐩𝐞𝐭𝐢𝐭𝐢𝐯𝐞 𝐦𝐚𝐫𝐤𝐞𝐭, 𝐢𝐧𝐝𝐮𝐬𝐭𝐫𝐲 𝐚𝐧𝐚𝐥𝐲𝐬𝐢𝐬 𝐢𝐬 𝐚 𝐜𝐫𝐢𝐭𝐢𝐜𝐚𝐥 𝐬𝐭𝐞𝐩 𝐢𝐧 𝐢𝐝𝐞𝐧𝐭𝐢𝐟𝐲𝐢𝐧𝐠 𝐭𝐡𝐞 𝐜𝐨𝐫𝐫𝐞𝐜𝐭 𝐭𝐚𝐫𝐠𝐞𝐭 𝐜𝐨𝐧𝐬𝐮𝐦𝐞𝐫𝐬 𝐚𝐧𝐝 𝐩𝐫𝐨𝐯𝐢𝐝𝐢𝐧𝐠 𝐜𝐮𝐬𝐭𝐨𝐦𝐢𝐬𝐞𝐝 𝐬𝐨𝐥𝐮𝐭𝐢𝐨𝐧𝐬 𝐟𝐨𝐫 𝐭𝐡𝐞𝐢𝐫 𝐛𝐮𝐬𝐢𝐧𝐞𝐬𝐬 𝐧𝐞𝐞𝐝𝐬. 𝐖𝐡𝐢𝐥𝐞 𝐟𝐨𝐫𝐦𝐮𝐥𝐚𝐭𝐢𝐧𝐠 𝐭𝐡𝐞𝐬𝐞 𝐬𝐨𝐥𝐮𝐭𝐢𝐨𝐧𝐬, 𝐞𝐯𝐞𝐫𝐲 𝐟𝐚𝐜𝐞𝐭 𝐚𝐧𝐝 𝐬𝐩𝐞𝐜𝐢𝐟𝐢𝐜 𝐩𝐫𝐨𝐛𝐥𝐞𝐦 𝐩𝐫𝐞𝐬𝐞𝐧𝐭𝐞𝐝 𝐛𝐲 𝐭𝐡𝐞 𝐩𝐚𝐫𝐭𝐢𝐜𝐮𝐥𝐚𝐫 𝐬𝐞𝐜𝐭𝐨𝐫 𝐢𝐬 𝐭𝐡𝐨𝐫𝐨𝐮𝐠𝐡𝐥𝐲 𝐜𝐨𝐧𝐬𝐢𝐝𝐞𝐫𝐞𝐝. 𝐈𝐭 𝐚𝐥𝐬𝐨 𝐜𝐨𝐧𝐬𝐢𝐝𝐞𝐫𝐬 𝐧𝐮𝐦𝐞𝐫𝐨𝐮𝐬 𝐠𝐨𝐯𝐞𝐫𝐧𝐦𝐞𝐧𝐭 𝐫𝐞𝐟𝐨𝐫𝐦𝐬, 𝐭𝐡𝐞 𝐜𝐨𝐦𝐩𝐞𝐭𝐢𝐭𝐢𝐯𝐞 𝐞𝐧𝐯𝐢𝐫𝐨𝐧𝐦𝐞𝐧𝐭, 𝐜𝐮𝐬𝐭𝐨𝐦𝐞𝐫 𝐛𝐞𝐡𝐚𝐯𝐢𝐨𝐮𝐫, 𝐜𝐮𝐫𝐫𝐞𝐧𝐭 𝐚𝐧𝐝 𝐟𝐮𝐭𝐮𝐫𝐞 𝐛𝐮𝐬𝐢𝐧𝐞𝐬𝐬 𝐬𝐭𝐫𝐚𝐭𝐞𝐠𝐢𝐞𝐬, 𝐚𝐧𝐝 𝐫𝐚𝐩𝐢𝐝𝐥𝐲 𝐜𝐡𝐚𝐧𝐠𝐢𝐧𝐠 𝐭𝐞𝐜𝐡𝐧𝐢𝐜𝐚𝐥 𝐛𝐫𝐞𝐚𝐤𝐭𝐡𝐫𝐨𝐮𝐠𝐡𝐬. 𝐈𝐧𝐝𝐮𝐬𝐭𝐫𝐲 𝐚𝐧𝐚𝐥𝐲𝐬𝐢𝐬 𝐚𝐢𝐝𝐬 𝐢𝐧 𝐭𝐡𝐞 𝐟𝐨𝐫𝐦𝐮𝐥𝐚𝐭𝐢𝐨𝐧 𝐨𝐟 𝐛𝐮𝐬𝐢𝐧𝐞𝐬𝐬 𝐩𝐥𝐚𝐧𝐬 𝐚𝐧𝐝 𝐩𝐨𝐥𝐢𝐜𝐢𝐞𝐬.”
There is a vast range of possible causes for circadian rhythm sleep disorder, but it has been associated with certain diseases such as Parkinson’s and Alzheimer’s disease. While no substance is known to trigger this disorder, irregular sleep-wake patterns are caused by individual choices. For instance, a delayed sleep phase may be caused by shift work or jet lag. Environmental factors such as lighting or noise may predispose someone to the disorder.
Treatment options for circadian rhythm sleep disorder vary greatly and depend on the severity of the condition and the patient’s quality of life. This sleep supplement can help re-orient the circadian rhythm and induce sleepiness. It is important to see a physician before using melatonin supplements to treat circadian rhythm sleep disorder.
Insomnia and fatigue are signs of a circadian rhythm sleep disorder. People with this condition may be more likely to commit errors at work, experience increased risk of accidents and suffer from irritability.
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Excessive daytime sleepiness:
The excessive daytime sleepiness can affect the drivers, As per public health, due to sleepiness at wheel (while driving) many road accidents happens. Population who suffers from excessive daytime sleepiness is about 5%.
Increase in sleep-wake disorders:
As per stated by AJMC, (The center for biosimilar), the prevalence of narcolepsy had increased about 14%, from 38.9 in 2013 to 44.3 in 2016. The OSA increased 41% of prevalence from the study period of 2429 to 3240. This increased prevalence was also observed in other examined sleep disorders.
Furthermore, increasing U.S. FDA approval, announcement of new information or manufacturing capabilities and agreements by market players are expected to boost the circadian rhythm sleep disorder market growth over the forecast period.
For instance, Vanda Pharmaceutical, in December 2020 announced that U.S. Food and Drug Administration (FDA) approved its HETLIOZ capsule and liquid formulations for the diagnosis of children and adults, associated with Smith-Magenis Syndrome (SMS) a development disorder which causes sleep disturbances.
Moreover, in October 2018, Eisai announced that they presented new information for phase II evaluation of Lemborexant, an experimental sleep-wake regulation agent, for the diagnosis of irregular sleep wake rhythm disorder in sufferer patient with mild to moderate Alzheimer’s disease. Alzheimer ’s disease data was presented in 11th Clinical Trials conference in Barcelona, Spain. Including insomnia disorder, Lemborexant is also developed for diagnosis of multiple sleep-wake disorders.
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Circadian Rhythm Sleep Disorders Market – Regional Insights
Among regions, North America and Europe are estimated to account for significant market share in the global circadian rhythm sleep disorders market. This is attributed to rising prevalence of chronic diseases (Obesity, Depression, Cardiovascular disease) and geriatric population. For instance, according to the European Commission, 2013 report, total 17% of European Population was above age 65 years. Therefore, rise in geriatric population is expected to drives growth of the circadian rhythm sleep disorders market in European Region. By National Library of Medicine, most common circadian rhythm sleep disorder is delayed sleep phase disorder with an estimated prevalence of 0.17% in the U.S. population and 7–16% prevalence among adolescents.
Circadian Rhythm Sleep Disorders Market – Taxonomy
By Treatment Type:
- Healthy Lifestyle Changes
- Bright Light Therapy
By Application Type:
- Delayed Sleep Phase Disorder
- Advanced Sleep Phase Disorder
- Jet Lag
- Shift Work Disorder
- Irregular Sleep Wake Rhythm
- Non-24-hour Sleep-wake Syndrome
By Distribution Channel:
- Institutional Sales
- Retail Sales
By End User:
- Home Care Settings
- Sleep Centers
- North America
- Asia Pacific
- Middle East & Africa
- Latin America
Circadian Rhythm Sleep Disorders Market – Competitive Landscape
Key players operating in the circadian rhythm sleep disorder market include:
- Vanda Pharmaceuticals
- Aeroflow, Inc.
- Cephalon, Inc.
- Takeda Pharmaceutical Company
- Teva Pharmaceutical Industries Ltd.
- Mylan N.V.
- The Sunbox Company
- Verilux, Inc.
- Northern Light Technologies
- Koninklijke Philips N.V.
- Amjo Corp.
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