The study undertaken by Astute Analytica forecasts a growth in revenue of the Global Molecular FISH Testing Market from US$ 645.2 Mn in 2021 to US$ 978.6 Mn by 2027. The market is registering a CAGR of 7.2% over the forecast period 2022-2027. The market is majorly driven by factors such as increasing prevalence of genomic abnormalities & cancers and growing adoption of new techniques for molecular-based cytogenetics.
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Market snapshot
Fluorescence in situ hybridization (FISH) is a ‘molecular cytogenetic technique in which using molecular probes, any type of chromosomal abnormalities can be encountered precisely by hybridization. It was developed by biomedical researchers in the early 1980s to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. The karyotyping takes at least 3 to 4 days to complete the entire process while the FISH method is rapid, one can get results within a day. Further, the cell culture process is not needed for performing FISH which is one of its most important advantages. Identification of specific chromosomal abnormality, especially structural as well as numerical; chromosomal deletion, duplication, and translocation can be detected using the fluorescence in situ hybridization. By using variations like SKY and M-FISH, new non-random genetic abnormalities can be identified as well. FISH can also be used to detect and localize specific RNA targets in cells, circulating tumor cells, and tissue samples.
Market Dynamics
Drivers:
The growing impetus of the market is attributed to factors such as increasing prevalence of genomic abnormalities & cancers and growing adoption of new techniques for molecular-based cytogenetics. Often parents of children with a developmental disability want to know more about their child’s conditions before choosing to have another child. These concerns can be addressed by analysis of the parents’ and child’s DNA. In cases where the child’s developmental disability is not understood, the cause of it can potentially be determined using FISH and cytogenetic techniques. Examples of diseases that are diagnosed using FISH include Prader-willi syndrome, Angelman syndrome, 22q13 deletion syndrome, chronic myelogenous leukemia, acute lymphoblastic leukemia, Velocardiofacial syndrome, and down syndrome. Furthermore, FISH can be used to form a diagnosis, to evaluate prognosis, or to evaluate remission of a disease, such as cancer. Treatment can then be specifically tailored. Therefore, the demand of FISH Probes in the medical sector has been increasing due to its function in analyzing biomarkers in tumor cells. Moreover, growing adoption of new techniques for molecular-based cytogenetics is also propelling market growth. By using variations like SKY and M-FISH, new non-random genetic abnormalities can be identified as well. Spectral karyotyping or multicolor FISH is a modification of native FISH in which using the different colored sequence-specific probe each chromosome can be painted thus, chromosomal rearrangement can be encountered precisely.
Restraints:
One of the biggest challenges of using FISH Techniques is its high cost. The expense of performing an advanced FISH test with complicated image analysis might be more than US$ 200,000, which hinders its adoption in research labs.
Opportunities:
Investments in pharmacogenomics and pharmaceutical research is expected to provide a lucrative opportunity for the expansion of molecular FISH testing market.
Regional Analysis
North America dominates the Global Molecular FISH Testing Market
North America holds the highest share in the Global Molecular FISH Testing Market in 2021 and is further expected to continue its dominance across the projection period. This is due to the rising incidence of cancer and infectious diseases in the region. Also, a considerable number of clinical research laboratories and academic institutes are also located in the region. The US is the highest shareholder country in North America molecular FISH testing market, while Mexico registers the highest CAGR over the forecast period.
Germany is the highest shareholder country in Europe molecular FISH testing market in 2021
Europe holds the second highest share in the Global Molecular FISH Testing Market in 2021. Germany holds the highest share in the molecular FISH testing market of Europe in 2021 due to rising demand for point-of-care diagnostics and recent advances in pharmacogenomics. Based on probe type, the whole chromosome segment has the highest market share in 2021. Further, cancer research is the highest application segment in the Europe molecular FISH testing market in 2021.
Asia Pacific holds the highest CAGR in the Global Molecular FISH Testing Market
Asia Pacific registers the highest annual growth rate in the Global Molecular FISH Testing Market over the forecast period. This is due to rising cytogenetics and molecular diagnostics industries in the region. Growing acceptance of novel molecular-based cytogenetics techniques, increased outsourcing operations, and need for early illness diagnosis and detection are expected to drive regional expansion. China is the highest shareholder country in the APAC molecular FISH testing market in 2021. Based on technology, the cryo FISH technology holds the highest share in the APAC market in 2021.
South Africa dominates the MEA molecular FISH testing market
South Africa is the highest shareholder country in Middle East & Africa molecular FISH testing market in 2021 and registers the highest CAGR over the projection period. This is due to increasing awareness about the benefits and potential of genetic testing among the MEA population. In terms of end users, clinical segment has the highest share in the molecular FISH testing market of MEA.
Brazil leads the molecular FISH testing market of South America
Brazil is the highest shareholder country in the South America molecular FISH testing market in 2021 due to an increased interest of Brazilian researchers in new diagnostics, as well as the country’s high prevalence of chronic diseases. Based on application, cancer research segment has the highest share in the molecular FISH testing market of South America. Further, the breast cancer research segment holds the highest share under the cancer research segment.
Competitive Insight
The key players in the global molecular FISH testing market are Thermo Fisher, Abbott Laboratories, Agilent, Oxford Gene Technology and ARUP Laboratories, among others.
Segmentation Overview
The following are the different segments of the Global Molecular FISH Testing Market:
By Technology segment of the Global Molecular FISH Testing Market is sub-segmented into:
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- Flow FISH
- Q FISH
- Immuno FISH
- Cryo FISH
- Other FISH
By Probe Type segment of the Global Molecular FISH Testing Market is sub-segmented into:
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- Locus specific
- Centromeric repeats
- Whole chromosome
By Cellular Stains segment of the Global Molecular FISH Testing Market is sub-segmented into:
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- DAPI (4,6-diamidino-2-phenylindole)
- Acridine Orange
- Others
By Application segment of the Global Molecular FISH Testing Market is sub-segmented into:
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- Cancer Research
- Lung
- Breast
- Bladder
- Hematological
- Gastric
- Prostrate
- Cervical
- Other
- Genetic Diseases
- Other
- Cancer Research
By End User segment of the Global Molecular FISH Testing Market is sub-segmented into:
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- Research
- Clinical
- Companion diagnostics
By Region segment of the Global Molecular FISH Testing Market is sub-segmented into:
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- North America
- The U.S.
- Canada
- Mexico
- Europe
- Western Europe
- The U.K.
- Germany
- France
- Italy
- Spain
- Rest of Western Europe
- Eastern Europe
- Poland
- Russia
- Rest of Eastern Europe
- Asia Pacific
- China
- India
- Japan
- Australia & New Zealand
- ASEAN
- Rest of Asia Pacific
- Middle East & Africa
- UAE
- Saudi Arabia
- South Africa
- Rest of Middle East & Africa
- South America
- Argentina
- Brazil
- Rest of South America
- North America
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