Because of ongoing innovation and development in this therapy, the worldwide CAR T cell market is rising at a rapid pace. From 2022 to 2027, the global CAR T cell therapy market is expected to grow at a phenomenal 52% CAGR.
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The coronavirus disease 2019 (COVID-19) pandemic caused by the extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spreading rapidly over the world. The COVID-19 pandemic is now affecting the availability of key routine healthcare facilities and procedures, including as CAR-T therapy, a life-saving treatment option for patients with R/R hematologic malignancies. Due to the rapid clinical progression of haematological malignancies, there is an immediate need to create and use CAR T-cells. However, during the COVID-19 epidemic, CAR-T treatment has become difficult. As a result, numerous medical and technological decisions will be required prior to, during, and after CAR-T therapy.
The purpose of this research is to provide timely advice for evaluating and selecting CAR T-cell treatment and appropriate CAR T-cell products, as well as infection-prevention strategies for medical personnel and patients, in light of the current COVID-19 outbreak. CAR T-cell treatment for patients with juvenile B-cell acute lymphoblastic leukaemia (ALL) and adult B-cell non-Hodgkin lymphomas has become more difficult due to the advent of the coronavirus disease 2019 (COVID-19) (NHL). Clinicians can overcome the difficulties of treating patients in the midst of a pandemic.
As the global prevalence of cancer climbs year after year and more people fail to respond to traditional therapies, the global CAR T cell therapy market is predicted to grow quickly.
To improve patient quality of life, a more efficient and reliable clinical treatment plan will be required as the number of adults and children diagnosed with cancer rises. The global CAR-T cell therapy market is expected to increase as a result of these advancements. Additionally, the government’s efforts to create healthcare facilities and increase cancer-cell treatment research are moving the company forward.
CAR-T cell therapy is still used to treat cancer in the majority of cases. According to the World Health Organization, cancer is remaining the leading cause of death worldwide (WHO). According to the World Health Organization, 18.1 million people have cancer, and over 9.6 million people died from it in 2018. Increased collaboration and mergers between pharmaceutical companies for research have resulted from the growing demand for cancer treatment. In 2018, Gilead Sciences Inc partnered with Sangamo Therapeutics Inc to develop cancer treatments using gene-editing technology. The three-billion-dollar deal is still a defining aspect of the CAR T-cell therapy sector.
Awareness about health and wellbeing, changes in various conditions, and government backing around the world are all important aspects driving the CAR T cell treatment industry forward. Despite the availability of t-cell treatment systems, all oncology specialty hospitals offer prompt therapy to patients in clinics and ambulatory centres, assisting in the development of the world’s largest CAR T cell market. Because it does not favour any other medicine, T cell therapy has the fastest growth rate in lymphoma treatment. The government’s increased support for implementing reimbursement schemes for the poor is driving up market demand. The CAR T cell therapy market has a new opportunity in the form of rapid industrial development and aid across all regions.
In addition, the adoption of sophisticated technology and innovative treatment processes with fewer side effects is predicted to accelerate the market’s growth pace. Increase in investments in cell therapy research centres is another significant factor boosting the market.
The demand for CAR T cell therapy is partly hampered by a lack of understanding in rural regions about the therapeutic process for cancer sickness. The cost of this therapy is a little high, making it unaffordable for most individuals, which is also limiting market demand. The CAR T cell therapy industry is projected to be hampered by an increase in adverse drug response concerns with cell therapy in Cytokine syndrome difficulties and neurological disorders.
Aside from that, concerns with the CAR-T cell manufacturing process, logistical challenges faced by healthcare organisations, as well as expensive treatments and poorly designed reimbursement systems, are stifling the industry’s expansion. Some people have had significant adverse effects as a result of this operation, according to the American Cancer Society, especially as the CAR T cells expand in the body to fight cancer. As CAR T cells grow, they produce a large number of molecules called cytokines, which are delivered into the circulation. The major side effects of this release can include extremely high fevers and dangerously low blood pressure in the days after treatment. Cytokine release syndrome is the name given to this illness (CRS). Another significant side effect is neurotoxicity, or changes in the brain that cause oedema, depression, seizures, or severe headaches. Another difficulty is that CAR T cells will kill some healthy B cells that aid in infection defence, placing the patient at danger of infection.
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KEY MARKET INSIGHTS:
- CD/19 and CD/22 held the highest share of the global market based on target antigen in 2020 and are likely to maintain their dominance during the forecast period. Several businesses have recently received approval for their antigens. It also expands the market for T cell treatment. Because of antigens like MUC16, ROR1, and L1CAM, B-cell maturation antigens are expected to develop the fastest.
- Due to favourable government reimbursement policies and simple and early access to CAR T Cell therapy, the North American market is likely to maintain its dominance in the global CAR T Cell therapy market over the projection period.
- The CAR T cell treatment market in the United States is likely to lead the North American CAR T cell therapy industry. Throughout the predicted period, it is expected to be the most dominant. The market in the United States is growing due to R&D in the cell therapy field, regular product approvals, and novel medications connected with it.
- In the future years, the Canadian CAR T cell treatment market is expected to grow at the quickest rate, followed by the United States. The market’s growth rate is being fuelled by rising healthcare spending, particularly in metropolitan regions. The market’s growth rate is being boosted by rising population and generating awareness through digital ads.
- With increased research on blood cancer treatment processes, Asia Pacific holds the largest share of the market, followed by North America. Because of China and India, Asia-Pacific is a booming market with various industrial businesses and a large number of cancer patients.
- In the following years, Asia Pacific is expected to have the greatest CAGR. The CAR T cell therapy market is expected to develop as more people become aware of the various treatment options available thanks to digital ads.
- Because of the growing number of hospitals with great infrastructure, China is leading the market with the largest share of the market. The demand for new technology-based creative techniques is growing. China has 4.3 million cancer patients, according to a recent poll.
- In terms of CAR T cell treatment market share, India is second only to China. As a result of changing lifestyles, the number of cancer cases in India is expected to rise in the future years. An increase in pharmaceutical enterprises and a rise in the number of clinical trials are driving the market’s expansion. The advent of these cancer-treatment technologies is increasing demand for the size of this country.
- In recent years, Japan’s economy has been booming, and the country is expected to have tremendous development potential in the next years.
- Among the market leaders are Mustang Bio, Inc., Celgene Corporation, Bluebird Bio, Inc., CARsgen Therapeutics, Ltd., Novartis International AG, Legend Biotech, and Pfizer, Inc.
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SEGMENTS INCLUDED IN THIS REPORT:
By Target Antigen:
- CD20
- EGFRV III
- CD19
- HER2
- MESO
- CD22
- BCMA
- GD2
- CD30
- HER1
- CD33
By Application:
- Multiple Myeloma
- Chronic Lymphocytic Leukemia
- Mantle Cell Lymphoma
- Follicular Lymphoma
- Diffuse large B-cell lymphoma
- Acute Lymphoblastic Leukemia
By Product:
- Allogeneic
- Autologous
By Therapies:
- Axicabtagene ciloleucel (Yescarta)
- Tisagenlecleucel (Kymriah)
By End User:
- Cancer Research Centers
- Hospitals
- Academic and Research Institutes
- Pharmaceutical Companies
- Biotechnology Companies
- Contract Research Organizations
By Region:
- North America
- Europe
- Asia Pacific
- Latin America
- The Middle East and Africa
Browse Regional Reports:
- North America CAR T cell Therapy Market
- Europe CAR T cell Therapy Market
- APAC CAR T cell Therapy Market
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