Another factual information on the “Natural Killer Cells Market” has as of late added by CMI to its storehouse. This research report offers an inside and out examination of various perspectives, for example, market patterns, pieces of the overall industry, drivers, restrictions, opportunities. It gives an investigative view to settle on further choices in organizations. It covers comprehensive instructive information of various key players working over the globe.
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Natural killer cells are effector lymphocytes of the innate immune system. They typically make up about 10% of total blood lymphocyte, compared to about 20% and 70% of B cells and T cells, respectively. Natural killer cells are capable of killing their target cells by two different mechanisms; as natural killer activity of these cells and as antibody dependent cell-mediated cytotoxicity. When a natural killer cell encounters any normal cell to generate a signal, lectin-like receptors engage its ligand, which in turn stimulates the natural killer cells to complete their process. Natural killer cells play an important role in immune response to a large variety of intracellular pathogens, they are often used to treat lymphomas and other disorders. This in turn is expected to augment the market growth.
There have also been studies to express the vitality of the response of natural killer cells against cells infected by various intracellular bacteria such as Legionella, Salmonella, and Listeria in humans. Recent advancements have proven the special role of killer cells in the innate immune response to microbial pathogens. Killer cells can also recognize pathogen derived structures on the surface of the infected cell. This in turn is expected to increase the adoption of the natural killer cells, driving the growth of the global natural killer cells market.
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Increase in applications of natural killer cells in the treatment critical diseases are expected to boost the growth of the global natural killer cells market over the forecast period. Natural killer cells play a vital role in stem-cell transplantation and may transfer exogenous cells through hematopoietic stem cell transplantation and adoptive cell therapy. For instance, according to the U.S. National Library of Medicine, the National Center for Biotechnology Information, in 2014, various studies have shown that such treatments are less effective at eliminating cancer stem cells.
Lethal midline granuloma (LMG) is an historical term for a condition in which necrotic and highly destructive lesions develop progressively in the middle of the face. Common causative lesions, in some patients, are lymphomas carcinomas, sarcoidosis, Wegener’s granulomatosis, and conventional Sino-nasal diffuse large B cell. However, such lesions often show atypical lymphoid cells among patients from South America and Asia. This in turn is also expected to propel growth of the global natural killer cells market over the forecast period.
Moreover, pro-inflammatory cytokines are secreted by activated natural killer cells, which then trigger Perforin/Granzyme induced target cell lysis. Their ability to discard stressed cells and specific attachment ability has led to an increasing adoption of natural cell therapies, which in turn is also expected to aid in the growth of the market.
Furthermore, market players are increasingly investing in research and development to offer, launch novel products in the market. For instance, R&D Systems offer a wide range of reagents for natural killer cell cultivation and investigating tumor cell and natural killer cell interactions and other components such as fluorochrome-conjugated antibodies, blocking/neutralization antibodies, recombinant proteins, and ELISA Kits.
Keen focus of various organizations towards immuno-oncology to is also expected to aid in the growth of the global natural killer cells market over the forecast period.
By Product Type:
- Malignant and Non-Malignant Cancer
- Stem Cell Transplantation
By End User:
- Clinical Research Institutes
- Cancer Research Institutes
- Research Universities
Key players operating in the global natural killer cells market are R&D Systems, CellGenix GmbH, Sorrento Therapeutics, Inc., Lonza, Glycostem, NantKwest, AvidBiotics, and NKT Therapeutics Inc., among others.
Market players are engaged in research and development to develop and launch novel products, as well as adopting various strategies (partnership and collaboration), to gain competitive edge in the market or expand their product portfolio.
In June 2019, NantKwest announced that the company’s PD-L1 t-haNK investigational new drug application (IND) has cleared the Food and Drug Administration (FDA) review and the program has now transitioned to a first-in-human clinical trial in patients with locally advanced or metastatic solid cancers.
In March 2019, Phio Pharmaceuticals and Glycostem Therapeutics collaborated to explore the potential synergies of using Glycostem’s proprietary Natural Killer-cell (NK-cell) generation technology and Phio’s self-delivering RNAi technology to develop cellular immunotherapies for cancer treatment with enhanced efficacy and/or safety.
In December 2018, Glycostem and Enpicom received funds to develop technology to predict the outcome of NK-Cell-based immunotherapy in patients with solid tumors.
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Table of Content
Global Natural Killer Cells Market Research Report
Section 1: Global Natural Killer Cells Industry Overview
Section 2: Global Economic Impact on Natural Killer Cells Industry
Section 3: Global Market Competition by Industry Producers
Section 4: Global Productions, Revenue (Value), according to Regions
Section 5: Global Supplies (Production), Consumption, Export, Import, geographically
Section 6: Global Productions, Revenue (Value), Price Trend, Product Type
Section 7: Global Market Analysis, on the basis of Application
Section 8: Natural Killer Cells Market Pricing Analysis
Section 9: Market Chain, Sourcing Strategy, and Downstream Buyers
Section 10: Strategies and key policies by Distributors/Suppliers/Traders
Section 11: Key Marketing Strategy Analysis, by Market Vendors
Section 12: Market Effect Factors Analysis
Section 13: Global Natural Killer Cells Market Forecast
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