Global BCL-2 (B Cell Lymphoma 2) Inhibitors Market and Clinical Trials Insight 2025 Report Highlights:
- Global BCL-2 Inhibitors Market Opportunity: >US$ 4 Billion by 2025
- Insight on Market Indicators and Approved Drugs Sales Data
- Global BCL-2 Inhibitors Market Absolute Growth: >300% ( 97% CAGR, 2018 – 2020)
- Comprehensive Information On Ongoing Clinical Trials
- Global BCL-2 inhibitors Clinical Trials By Company, Indication and Phase
- Venetoclax Is The First Approved Drug Belonging To The Class Of BCL2 Inhibitor
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B-cell lymphoma 2 genes are crucial genes which are involved in regulating the balance between newly forming cells and old dying cells. Bcl-2 was the first gene which has shown to promote prolonged cell survival rather than increased proliferation. However, any mutation in this gene results in formation of cancer and therefore they emerged as potential target to the researchers. Several cancers including breast, lymphoma, leukemia and lung cancer expresses a high amount of Bcl2. The therapeutic potential of this target has led to the development of Bcl-2 inhibitor which can be used in the management of cancer.
Venclexta/Vencylyxto is a first in class targeted drug designed to selectively bind and inhibit the B-cell lymphoma-2 (BCL-2) protein. The drug was developed by collaboration between Abbie and Roche. The drug is indicated as monotherapy as well as combinational therapy for the management of chronic lymphocytic leukemia, and acute lymphoblastic leukemia. In addition to CLL and AML, venetoclax has also been evaluated in other hematological malignancies including lymphomas and multiple myeloma. Apart from this, around 300 trials are ongoing which are evaluating the role of drug in combination with other cancer targeting regimens, which will drive the growth of market during forecast period.
The advent of Bcl-2 inhibitor in the management of cancer has greatly transformed the cancer therapeutics market. In a short span of time, Bcl2 inhibitory drugs have contributed to a significant share in the cancer therapeutics market owing to their high specificity and target ability towards cancer cell. Unlike conventional cancer therapies, the novel class of Bcl-2 inhibitors is not associated with any adverse side-effects and does not hamper the quality of life of patients, which further propel the growth of market.
The accelerated sales of the drug and the significant advantages have drawn the attention of several researchers and pharmaceutical companies to invest in this sector. The extensive efforts by the researchers and the rising collaboration among the pharmaceutical giants are expected to drive the future of the market in coming years. Till now, scientists have developed a cocktail of drugs has been developed which are mainly present in the early stages of the clinical trials and will take about 5-7 years to enter the market. The potential candidates in development include AZD4320, LP-108, Navitoclax, AT-101, and several others.
Although venetoclax has demonstrated impressive initial clinical activity in various hematological malignancies; intrinsic or acquired drug resistance represents a major obstacle for achieving effective and durable therapy with this agent. However, continuous research and development activities by researchers have led to identification of resistance mechanisms. Several preclinical studies utilizing combinational therapy has shown to overcome Venetoclax resistance. As per our report, the coming years will see dominace of combinational therapy owing to its high efficacy in targeting cancer.
The presence of large pharmaceutical sector and favourable governmental policies in US are expected to drive the dominance of the region for the next few years. In addition to this, the rising awareness among the individuals about the availability of the novel therapies and the increasing geriatric population will further fuel the growth of the market in this region. Apart from this, Europe is also emerging as a potential market due to subsequent rise in incidence of cancer. It is expected that in coming years, Bcl2 inhibitors will contribute to a major share in the overall cancer therapeutics market.
Contact:
Neeraj Chawla
Research Head
+91-9810410366