Increasing research and development activities, advancements in genomics, and rising awareness regarding benefits of whole exome sequencing are some key factors expected to drive market growth
Whole exome sequencing is a widely used and important next-generation sequencing technique that efficiently sequences all protein-coding regions in a genome. Whole exome sequencing is primarily used to screen and identify variations and mutations in the protein-coding regions. Whole exome sequencing can accurately detect genetic mutations that are related to birth defects and development delays. Increasing awareness regarding benefits of whole exome sequencing in detecting genetic disorders, rising investment to accelerate genomics and proteomics research, and adoption of cutting-edge technologies are key factors expected to drive market revenue growth over the forecast period.
Whole exome sequencing is a genomic technique that sequences all protein-coding regions in a genome by selecting subset of DNA that encode proteins and then sequencing the exonic DNA through high-throughput DNA sequencing technological. Whole exome sequencing aims to identify genetic variants that alter protein sequences and has been widely used in academic research and as a clinical diagnostic tool. Whole exome sequencing is increasing being used to complement other genetic tests to find mutations in genes known to cause diseases and identify novel genes by comparing exomes from patients with similar attributes. Whole exome sequencing has proven to be an effective tool for discovery of genetic defects in patients having primary immunodeficiencies. It is also an effective tool for molecular diagnosis of rare monogenic disorders, identification of de novo variants in complex diseases, and tumor analysis to identify genes responsible for cancer.
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Whole genome sequencing is increasingly cost-effective as compared to whole genome sequencing and is extensively used to identify underlying disease gene mutations to make informed diagnostic and therapeutic decisions and treat at-risk family members. Extensive research is being carried out to understand the application of whole exome sequencing in rare variant gene discovery and this is expected to further drive revenue growth of the market. However, ethical issues associated with this technique, shortage of skilled professionals, and concerns regarding sensitivity of exome sequencing can hamper its adoption and restrain market growth over the forecast period.
COVID-19 Impact Analysis
- The virus outbreak and social distancing norms and restrictions severely disrupted the overall business landscape and operations worldwide.
- COVID-19 pandemic and lockdowns have resulted in several countries shutting down airports, ports, and commercial and domestic transportation. This had impacted manufacturing activities and operations globally and took a toll on the economy of various countries.
- Sudden and drastic downturn in economic activity caused a slowdown in manufacturing, production, import/export, and other sectors and also resulted in employment loss to a major extent.
- Supply impacts were further compounded due to challenges on the demand-side owing to reduced disposable income, depleting savings, and increased concerns and uncertainties.
- Emergence of variants of the virus and rise in infection rates during the initial waves and subsequent lockdowns has severely impacted operations and disrupted supply chains.
Services Segment to Account for Largest Revenue Share:
Services segment to account for largest revenue share over the forecast period owing to increasing demand for high-throughput data analysis services. Data analysis and NGS services cover a wide range of services from experimental design to library generation to help researchers and scientists overcome limitations of bioinformatics-related problems and save time and reduce expenses.
Sequencing by Synthesis to Register Rapid Revenue CAGR:
Sequencing by synthesis is expected to register rapid revenue CAGR over the forecast period owing to increasing adoption of this method for whole exome synthesis attributable to its benefits such as accurate base-by-base sequencing, precise data for various applications, minimal errors, and reduced probability of repeated nucleotides.
Personalized Medicine Segment to Register Significant Revenue Growth:
Personalized medicine segment is expected to dominate other application segments in terms of revenue growth attributable to rising need for customized therapeutic approaches for chronic and rare diseases, rapid progress in genetic medicine, and increasing application of whole exome sequencing in developing advanced diagnostic and therapeutic approaches.
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North America to Account for a Significantly Large Revenue Share:
North America is expected to account for a significantly large revenue share over the forecast period owing to growing focus on personalized medicine, increasing R&D activities in the field of genomics and proteomics, rising application of whole exome sequencing in detection of rare genetic disorders, and robust presence of key market players.
Key Companies in the Market Include:
- Illumina, Inc.
- Thermo Fisher Scientific, Inc.
- Agilent Technologies
- Hoffman-La Roche AG
- Eurofins Scientific Group
- GENEWIZ, Inc.
- Knome, Inc.
- Macrogen, Inc.
- Ambry Genetics Corp.
- Beijing Genomics Institute
For the purpose of this report, Emergen Research has segmented the global whole exome sequencing market on the basis of product, application, technology, end-use, and region:
Product Outlook (Revenue, USD Million; 2018-2028)
- DNA Fragmentation End Repair, A-Tailing and Size Selection
- Library Preparation Kits
- Target Enrichment Kits
- Sequencing Services
- Data Analysis Services
Application Outlook (Revenue, USD Million; 2018-2028)
- Monogenic Disorders
- Drug Discovery and Development
- Personalized Medicine
- Agriculture and Animal Research
Technology Outlook (Revenue, USD Million; 2018-2028)
- Sequencing by Synthesis
- Ion Semiconductor Sequencing
End-Use Outlook (Revenue, USD Million; 2018-2028)
- Academic Institutions & Research Centers
- Hospitals & Clinics
- Pharmaceutical & Biotechnology Companies
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Regional Outlook (Revenue, USD Million; 2018-2028)
- North America
- Rest of Europe
- Asia Pacific
- South Korea
- Rest of APAC
- Latin America
- Rest of LATAM
- Middle East & Africa
- Saudi Arabia
- South Africa
- Rest of MEA
- Rest of MEA
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