Phenylalanine is the vital alpha amino acid that functions for maintaining adequate monoamine neurotransmitter levels within the brain, which in turn maintains balanced moods. Phenylalanine deficiency causes depression, mental confusion, reduced alertness, loss of appetite, and memory impairment. Phenylalanine is present majorly in three types L-Phenylalanine, DL-Phenylalanine, and D-Phenylalanine. L-phenylalanine is the natural amino-acid found within the proteins, whereas D-Phenylalanine is phenylalanine’s synthesized form, produced at laboratory. The DL-phenylalanine is a synthetic product produced with half D-phenylalanine and half L-phenylalanine.
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L-phenylalanine is the vital amino acid that is also the only phenylalanine form found in proteins. Key dietary sources for L-phenylalanine are meat, fish, cheese, milk, and eggs. DL-phenylalanine and L-phenylalanine are used commonly for treatment of depression, chronic pain, Attention Deficit-Hyperactivity Disorder (ADHD), along with a skin condition called vitiligo.
The phenylalanine’s primary function is the production of tyrosine, which gets further converted into 3 major neurotransmitters namely norepinephrine, epinephrine, and L-dopa. As certain antidepressants function through increasing norepinephrine levels, various phenylalanine forms have been regarded as a potential treatment for depression. Moreover, D-phenylalanine was found to be effective in chronic pain treatment.
Global Phenylalanine Market Drivers
Increasing depression and anxiety prevalence are causing massive anti-depressant consumptions, which in turn, is expected to drive growth of the global phenylalanine market over the forecast period. For instance, as per the 2017 data findings from World Health Organization (WHO), around 300 million individuals of every age are enduring from depression globally, wherein over 800,000 individuals die from suicide owing to depression and anxiety disorders as leading cause. Moreover, as per the National Institute of Mental Health (NIMH), around 10.3 Mn adults in the U.S. (4.3% of total U.S. adults) aged 18 years and above suffered from minimum one massive depressive episode having severe impairment, in 2016. Furthermore, as per the similar source, the incidence of major cases of depression was high in adult females (8.5%) than males (4.8%). Moreover, the incidence of adults suffering a massive depressive episode was most among people aged 18-25 years (10.9%). The association (NIMH) even mentions that the disorders are extremely treatable thereby expected to propel growth of the global phenylalanine market over the forecast period.
Furthermore, high chronic pain diseases’ prevalence is expected to drive the global phenylalanine market growth over the forecast period. For instance, in 2011, as per the American Academy of Pain Medicine (AAPM), over 1.8 Bn people endured with chronic pain. Furthermore, the National Institutes of Health (NIH) estimates that 10% of the U.S. populace suffer with chronic pain. As per the British Medical Journal published study in 2016, over 33% of the populace in the U.K. has chronic pain. Furthermore, as per the 2015 published NIH estimates by the American Pain Society, over 50 Mn people in the U.S. endured with chronic pain.
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Furthermore, rising prevalence of chronic diseases and pain including cancer and other are expected to drive the global phenylalanine market growth over the forecast period. For instance, in 2018, as per the National Cancer Institute, over 1,735,350 new cancer cases are expected to be registered in the U.S. whereas 609,640 individuals are expected lose their lives due to the disease.
Global Phenylalanine Market Restraints
Side effects associated with Phenylalanine are expected to restrain growth of the global phenylalanine market over the forecast period. Phenylalanine must be avoided by people with some inherited disorders including Phenylketonuria (PKU), in which the body builds up excessive phenylalanine. People having phenylketonuria could develop high blood pressure, mental retardation, stroke, and various other serious issues of health if they phenylalanine is consumed.
Global Phenylalanine Market – Regional Analysis
Based on geography, the global phenylalanine market is segregated into North America, Europe, Latin America, Middle East, Africa, and Asia Pacific. Increasing prevalence of cancer and increasing number of cases of trauma globally is expected to propel demand of management of pain related to it. North America region is expected to register robust growth over the forecast period. According to the Centers for Disease Control and Prevention (CDC) published statistics in 2014, around 41 Mn visits to emergency ward are accounted for trauma annually in the U.S.
Furthermore, developed economies including the U.S., Germany, and the U.K. experience high adoption rate owing to better facilities of healthcare and easy accessibility of depression medicines in the countries. As per the American academy of pain medicine, annually over 100 Mn individuals endure with chronic pain, over 25.8 Mn from diabetes, over 16.3 Mn from coronary heart disease, and over 11.9 Mn from cancer within the U.S. The number is projected to increase further over the forecast period.
Increasing initiatives of R&D by several non-government and governmental organizations including the National Institutes of Health (NIH) Brain Research through Advancing Innovative Neurotechnologies (BRAIN) that aims at gaining better understanding of the human brain along with harnessing the same in several therapeutic applications, such as effective management of pain, is expected to produce conducive environment for growth of the global phenylalanine market in these region.
Global Phenylalanine Market – Competitor
Major players functioning in the global phenylalanine market are Amazing Nutrition, NutraMarks, Inc., LiftMode (Synaptent LLC), NOW foods, Shijiazhuang Jirong Pharmaceutical Co., Ltd., and healthvit.
Global Phenylalanine Market Taxonomy
Based on Type
Based on Application:
- Chronic Pain
Based on Distribution Channel:
- Retail Pharmacy
- Hospital Pharmacy
- Online Pharmacy
Based on Region
- North America
- Latin America
- Asia Pacific
- Middle East
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