Increasing awareness regarding benefits of organs-on-a-chip in organ transplantation, rising focus on developing improved animal models, and growing investment to accelerate research and development activities are some key factors expected to drive market growth
According to Emergen Research, the global organs on chip market size was USD 27.5 Million in 2020 and is expected to reach USD 209.4 million in 2028 and register a revenue CAGR of 28.1% during the forecast period, 2021-2028.
Increasing demand for organ on chips for drug research and development, in organ transplantation, for development of precision medicine, and for building models of complex human diseases is a key factor expected to drive revenue growth of the market over the forecast period. Organ-on-a-chip technology offers a novel and robust in vitro platform that can mimic and reproduce physiological functions of in vivo tissues. They can mimic multilevel organ functions that can be beneficial during screening of drugs and treatments and reduces the need for live animals. Organs-on-chips are also known as microphysiological systems or tissue chips and have gained substantial interest over the recent years due to the potential to be highly important and informative in every stage of drug discovery and development process and this is another key factor expected to contribute to revenue growth of the market going ahead.
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Organs-on-chips are capable of providing insights into normal functioning of organs in humans and disease pathophysiology. They are also capable of predicting safety and efficacy of investigational drug candidates in humans. These innovative microfluidic devices are small in size and are developed with increased complexity. They can efficiently control the movement and behavior of materials and cells by using channels, chambers, and membranes. A major advantage of these systems is the integration of sensors that enables real-time monitoring of physical, biochemical, and optical parameters in situ. With the development of multi-sensor platform, drug discovery, preclinical drug testing, and pharmacodynamic studies will enable accurate prediction of toxicity and treatment outcome.
Organs-on-chip approach is mainly relevant for diseases that are specific to humans and for which no animal models are known. Representative cell lines or animal model systems do not exist for many human psychiatric and neurological diseases, and diseases in which immune system plays a critical role such as autoimmune diseases or cancer. Development of drugs for all these diseases can be possible through organs-on-chips technology using stem cells from the patient with disease of interest and extensive research activities to explore this potential is another key factor expected to fuel revenue growth of the market going ahead.
Over the recent years, potential of organ-on-a-chip as novel in vitro model systems for drug screening and disease models has been explored extensively. Research and development activities are being carried out across the globe for the development of more complex multi-organ systems where organ molecules can interact with one another and mimic biological processes in the body and this is expected to further contribute to market growth.
COVID-19 Impact Analysis
- Social distancing and restrictions severely disrupted businesses and operations
- Lockdowns caused disruptions in transportation and logistics
- Impacted manufacturing activities and mining operations globally
- Took a toll on economy of various countries
- Caused sudden and drastic downturn in economic activity
- Disrupted agriculture, fisheries, dairy, and other sectors
- Caused loss of employment and financial crisis
- Supply impacts were further compounded owing to reduced disposable income
- Emergence of variants continue to cause concerns and impact normal routines
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Heart-on-chip Segment to Account for a Significantly Large Revenue Share:
Heart-on-chip segment is expected to account for a significantly large revenue share over the forecast period attributable to increasing need for efficient treatment of heart disorders due to growing prevalence of cardiovascular diseases across the globe. Heart-on-chip device can reproduce the mechanisms of heart and enable quick testing of drugs and medications and understand the response of heart cells to the medicine. Heart-on-chip models have been developed to study the cardiac pathophysiology and test safety and efficacy of drugs in vitro and this is also a key factor contributing to revenue growth of this segment.
Increasing use of Organ-on-a-Chip for Drug Discovery and Development:
Drugs discovery segment is expected to register significant revenue growth over the forecast period owing to increasing development of organs-on-chips for various disease indications to test the efficacy of drugs at every stage of drug discovery and development processes. Use of organ-on-a-chip model provides a microenvironment that efficiently mimics the pathophysiological conditions of human body that significantly helps in drug research and reduce costs associated with trial and error and methods.
North America to Lead in Terms of Revenue Share:
North America is expected to account for largest revenue share over the forecast period attributable to increasing investment to accelerate pharmaceutical and biotechnology research, extensive R&D activities for development of robust organ-on-a-chip models, rapid advancements in drugs discovery and research, increasing incidence of chronic diseases, and presence of key companies in the region.
Major Companies in the Market Include:
- MIMETAS BV
- SynVivo Inc.
- Emulate Inc.
- InSphero AG
- CN Bio
- Nortis Inc.
- Organovo Holdings Inc.
- TissUse GmbH
- AxoSim Inc.
- Kirkstall Ltd
For the purpose of this report, Emergen Research has segmented the global organ on a chip market on the basis of type, application, end-use, and region:
Type Outlook (Revenue, USD Million; 2018–2028)
- Multiple organ on a chip
Application Outlook (Revenue, USD Million; 2018–2028)
- Drug Discovery
- Physiological Model Development
- Toxicology Research
End-Use Outlook (Revenue, USD Million; 2018–2028)
- Pharmaceutical Firms
- Research Institutes
- Personal Care Industry
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Regional Outlook (Revenue, USD Million; 2018–2028)
- North America
- Rest of Europe
- Asia Pacific
- South Korea
- Rest of APAC
- Latin America
- Rest of LATAM
- Middle East & Africa
- Saudi Arabia
- South Africa
- Rest of MEA
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