Increasing application of DNA origami in developing robust drug delivery systems, efficient engineering of nanoscale structure and devices, and production of complex nanorobots are some key factors expected to drive market growth
DNA origami refers to the nanoscale folding of DNA to create 2D or 3D shapes at nanoscale such as nanorobots that can work as smart drugs when successfully delivered to cells. DNA origami technique uses hundreds of short oligonucleotides to fold a single-stranded DNA into various numerous nanoscale architectures. DNA origami has significantly improved complexity and scalability of DNA nanostructures and has provided a versatile platform for development of nanoscale structures and devices. This has boosted its application in a wide range of fields such as chemistry, biology, material science, and computer science, among others. Rapid advancements in molecular robotics and development of robust drug delivery systems for cancer therapy are key factors expected to drive market revenue growth over the forecast period.
DNA origami uses a very long strand DNA called the scaffold strand which is held together in the desired configuration through simple base-pairing with hundreds of short staple strand oligonucleotides. DNA origami is extensively used to construct nanorobots and other structures for fluorescence studies, enzyme-substrate interactions, drug delivery, and light and energy studies, among others. Nanorobots can carry gold, silver, or other nanoparticles to enable study of the interactions between various molecules and their workings. Origami structures can also be designed to for efficient delivery of enzymes to their substrate or halt the interaction. One of the most promising therapeutic applications of DNA origami is drug delivery wherein drugs are encased by origami structures before administration into desired cells.
DNA origami structures efficiently target cancer cells and improve survival rate of the patient. DNA origami has broadened the scope of DNA nanotechnology based on the programmed assembly of branched DNA junctions. Increasing research and development activities to develop feasible drug delivery systems and create dynamic nanostructures is another key factor expected to contribute to revenue growth of the market going ahead.
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However, DNA origami technique is cost- and time-intensive, which is a key factor expected to restrain market growth to a certain extent over the forecast period. In addition, lack of knowledge regarding DNA origami and unavailability of user-friendly and robust design for DNA origami is also expected to hamper adoption of this technique and restrain market growth going ahead.
COVID-19 Impact Analysis
- The virus outbreak and social distancing norms and restrictions severely disrupted the overall business landscape and operations worldwide.
- COVID-19 pandemic and lockdowns have resulted in several countries shutting down airports, ports, and commercial and domestic transportation. This had impacted manufacturing activities and operations globally and took a toll on the economy of various countries.
- Sudden and drastic downturn in economic activity caused a slowdown in manufacturing, production, import/export, and other sectors and also resulted in employment loss to a major extent.
- Supply impacts were further compounded due to challenges on the demand-side owing to reduced disposable income, depleting savings, and increased concerns and uncertainties.
- Emergence of variants of the virus and rise in infection rates during the initial waves and subsequent lockdowns has severely impacted operations and disrupted supply chains.
Single-stranded Scaffold DNA Segment to Register Significant Revenue Growth:
Single-stranded scaffold DNA segment is expected to register significant revenue growth over the forecast period attributed to increasing availability of different lengths of single-stranded DNA scaffold for different experiments.
Static Segment to Register Steady Revenue CAGR:
Static segment is expected to register robust revenue CAGR over the forecast period. Static structures include DNA in various shapes that enable researchers to fold their own DNA structures. Static DNA nanostructures have been widely used in cancer therapeutics and this is expected to further contribute to revenue growth of the market going ahead.
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Nanorobots and Fluorescence studies segment to Account for a Significantly Large Revenue Share:
Nanorobots and fluorescence studies segment is expected to account for largest revenue share over the forecast period attributable to increasing progress in molecular robotics and development of nanorobotic drug delivery systems.
North America to Account for Largest Revenue Share:
North America is expected to account for largest revenue share over the forecast period attributed to increasing investment and funding to accelerate molecular biology research, rising number of research studies to expand the application scope of DNA origami, and presence of key players in the region.
Major Companies in the Market Include:
- DNA Technologies IDT
- Tilibit Nanosystems
- Eurofins Genomics
- Twist Bioscience Corporation
- GATTAquant DNA Technologies
- Dietz Lab
- ADINA R&D, Inc.
- Kosuri Lab
- Cees Dekkar Lab
For the purpose of this report, Emergen Research has segmented the global DNA origami market on the basis of type, structure, application, and region:
Type Outlook (Revenue, USD Million; 2018-2028)
- Single-stranded Scaffold DNA
- Folding Kits
- Staple Strand Oligos
Structure Outlook (Revenue, USD Million; 2018-2028)
Application Outlook (Revenue, USD Million; 2018-2028)
- Nanorobots and Fluorescence Studies
- Enzyme-substrate Studies
- Studies of Molecular Motors
- Light, Energy, and Microscopy Studies
- DNA Origami Drug Delivery
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Regional Outlook (Revenue, USD Million; 2018-2028)
- North America
- Rest of Europe
- Asia Pacific
- South Korea
- Rest of APAC
- Latin America
- Rest of LATAM
- Middle East & Africa
- Saudi Arabia
- South Africa
- Rest of MEA
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