Rising prevalence of neurological diseases, development of effective drug delivery systems, and growing geriatric population are some key factors expected to drive market growth
According to Emergen Research, the global blood-brain barrier (BBB) market size was USD 1.25 Billion in 2020 and is expected to reach USD 7.40 Billion in 2028 and register a revenue CAGR of 24.8% during the forecast period, 2021-2028.
Market Dynamics:
The blood-brain barrier (BBB) is the interface between the central nervous system (CNS) and the peripheral nervous system (PNS). It is a component of the neurovascular unit (NVU), which prevents circulation of pathogens or toxins that cause brain infections, while allowing essential nutrients to reach the brain. BBBs are not just physical barriers (because of specific tight junctions that prevent unregulated leakage) but they also act as specific transport interfaces (due to specific transporters present on abluminal and luminal membranes) and a metabolic barrier (releasing enzymes locally). Damage or weakening of the BBB allows immune cells to cross it. These cells then attack the myelin around nerves, causing nerve damage and MS symptoms.
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Increasing incidences of CNS disorders and complications and growing need to treat these CNS disorders has resulted in increasing number of R&D activities on BBB and its related technologies. Development of robust drug delivery systems for brain, use of nanocarriers to deliver drugs to the brain, and reengineering biologics with BBB drug delivery technology, among other recent advancements have significantly contributed to market revenue growth and are expected to continue to drive market growth over the forecast period.
In addition, integration of advanced technologies such as artificial intelligence (AI) in magnetic resonance imaging and large scale adoption of ultrasound and nanotechnology are some major factors expected to positively impact revenue growth of the market. However, high cost of machine, lack of awareness regarding latest technologies, and strict government regulations on the approval of drugs are some factors expected to restrain market growth to a significant extent over the forecast period.
COVID-19 Impact Analysis
- Social distancing and restrictions severely disrupted businesses and operations
- Lockdowns caused disruptions in transportation and logistics
- Impacted manufacturing activities and mining operations globally
- Took a toll on economy of various countries
- Caused sudden and drastic downturn in economic activity
- Disrupted agriculture, fisheries, dairy, and other sectors
- Caused loss of employment and financial crisis
- Supply impacts were further compounded owing to reduced disposable income
- Emergence of variants continue to cause concerns and impact normal routines
Increasing Permeability Segment Revenue to Expand at a Rapid CAGR:
Increasing permeability segment is expected to register a rapid revenue CAGR over the forecast period attributed to increasing research activities on central nervous system (CNS) disorders and growing government investment to accelerate technological developments in BBB drug delivery technologies.
Hospital Segment to Register Significant Revenue Growth:
Hospital segment is expected to register significant revenue growth over the forecast period due to healthcare infrastructure developments (especially during COVID-19), medical innovation, increasing government and health organizations initiatives on regular health checkups and rising affordability in medical services due to implementation of favorable government and private medical insurance policies.
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North America to Account for Largest Revenue Share:
North America is expected to account for largest revenue share in the global market over the forecast period due to rising healthcare expenditure, growing popularity of nanotechnology, and increasing pharmaceutical R&D for development of new and effective drugs. In addition, presence of key players and increasing number of patients suffering from CNS disorders are some other factors expected to contribute to market growth in the region.
Major Companies in the Market Include:
- Allon Therapeutics, Inc.
- Angiochem Inc.
- Armagen Technologies, Inc.
- Bristol-Myers Squibb
- BiOasis Technologies, Inc.
- Sanofi Genzyme
- CarThera
- Cephalon Inc.
- Nanomerics
- Hoffman La-Roche AG
For the purpose of this report, Emergen Research has segmented the global blood-brain barrier (BBB) based on application, technology, end-use, and region:
Application Outlook (Revenue, USD Billion; 2018–2028)
- Alzheimer’s Disease
- Epilepsy
- Parkinson’s Disease
- Multiple Sclerosis
- Hunter’s Syndrome
- Brain Cancer
Technology Outlook (Revenue, USD Billion; 2018–2028)
- Bispecific Antibody RMT Approach
- Trojan Horse Approach
- Increasing Permeability
- Passive Diffusion
- Others
End-Use Outlook (Revenue, USD Billion; 2018–2028)
- Hospitals
- Surgical centers
- Research Institutes
- Others
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Regional Outlook (Revenue, USD Billion; 2018–2028)
- North America
- S.
- Canada
- Mexico
- Europe
- Germany
- France
- K.
- Italy
- Spain
- BENELUX
- Rest of Europe
- Asia Pacific
- China
- India
- Japan
- South Korea
- Rest of APAC
- Latin America
- Brazil
- Rest of LATAM
- Middle East & Africa
- Saudi Arabia
- A.E.
- South Africa
- Turkey
- Rest of MEA
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