Rising prevalence of cancer, surge in research and development activities, and increasing geriatric population are some key factors expected to drive market growth
According to Emergen Research, the global antibody-drug conjugates market size was USD 3.18 billion in 2020 and is expected to reach USD 20.01 billion in 2028 and register a revenue CAGR of 25.8% during the forecast period, 2021-2028.
Antibody-Drug Conjugates Market Dynamics:
ADCs, or antibody-drug conjugates, are highly targeted biopharmaceutical therapies that combine monoclonal antibodies specific to surface antigens found on specific tumour cells with highly effective anti-cancer medications linked via a chemical linker. ADCs are also known as empowered antibodies (mAbs) and are safer than other types of cancer therapies. This has boosted demand for antibody-drug conjugates and is expected to drive market revenue growth over the forecast period.
Ongoing R&D activities on preclinical research, technological advancements in synthetic biochemistry along with the government favorable regulations for introduction of advanced drug discoveries are some factors expected to positively impact revenue growth of the market over the forecast period. In addition, rising number of cancer patients worldwide due to unhelathy lifestyle and surge in consumption of alcohol are another key factors expected to fuel revenue growth of the market going ahead. According to 2021 report by World Health Organization (WHO), cancer is a leading cause of death globally and approximately 70% of cancer deaths occur in middle and low income countries.
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However, high cost of treatment, lack of skilled professionals and stringent regulations can hamper market growth to a certain extent over the forecast period. Further, disadvantages associated with antibody-drug conjugates can negatively impact revenue growth of the market. ADC disadvantages include linker technological issues, as synthesis/design of bio-functional is difficult due to the need for specialist teams. ADC must be made in an aseptic environment, and working employees must be shielded from very hazardous drug molecules, posing operational challenges.
COVID-19 Impact Analysis
- Social distancing and restrictions severely disrupted businesses and operations
- Lockdowns caused disruptions in transportation and logistics
- Impacted manufacturing activities and mining operations globally
- Took a toll on economy of various countries
- Caused sudden and drastic downturn in economic activity
- Disrupted agriculture, fisheries, dairy, and other sectors
- Caused loss of employment and financial crisis
- Supply impacts were further compounded owing to reduced disposable income
- Emergence of variants continue to cause concerns and impact normal routines
Non-Cleavable Linkage Segment Revenue to Expand at a Rapid CAGR:
Non-cleavable linkage segment is expected to register a rapid revenue CAGR over the forecast period attributed to increased plasma stability. These linkers offer a greater therapeutic window due to the fact that the payload derivative from non-cleavable antibody-drug conjugates can kill target cells. It also provides great tolerability and stability.
Blood Cancer Segment to Register Significant Revenue Growth:
Blood cancer segment is expected to register significant revenue growth over the forecast period owing to increasing incidences of patients suffering from blood cancer, availability of advanced treatment options, and rising usage of products, such as Adcetris, Polivy, and Blenrep.
North America to Account for Largest Revenue Share:
North America is expected to account for largest revenue share in the global market over the forecast period due to advanced healthcare infrastructure, increasing number of clinical trials, and increasing awareness among people regarding regular health checkup. Further, availability of AI-based technologies for better outcomes, presence of highly skilled surgeons and increase in number of cancer patients in the countries in the region is expected to drive market growth.
Major Companies in the Market Include:
- Oxford BioTherapeutics
- Bayer AG, Immunomedics Inc.
- Concortis Biotherapeutics
- Hoffman-La Roche Ltd.
- Pfizer Inc.
- ImmunoGen Inc.
- AbbVie Inc.
- Sanofi S.A.
- Takeda Pharmaceutical Company Limited.
For the purpose of this report, Emergen Research has segmented the global antibody-drug conjugates market on the basis of technology, application, end-use, and region:
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Technology Outlook (Revenue, USD Billion; 2018–2028)
- Cleavable Linker
- Non-Cleavable Linker
Application Outlook (Revenue, USD Billion; 2018–2028)
- Blood Cancer
- Brain Tumor
- Ovarian Cancer
- Breast Cancer
- Lung Cancer
End-use Outlook (Revenue, USD Billion; 2018–2028)
- Research Institute
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Regional Outlook (Revenue, USD Million; 2018–2028)
- North America
- Rest of Europe
- Asia Pacific
- South Korea
- Rest of APAC
- Latin America
- Rest of LATAM
- Middle East & Africa
- Saudi Arabia
- South Africa
- Rest of MEA
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