Amitriptyline is a tricyclic antidepressant that is used to treat a variety of health conditions such as chronic neuropathic pain, depression, and others. The medication is also used to treat migraines in Off-label. Certain chemical messengers (neurotransmitters) that interact between brain cells and help control mood are affects by amitriptyline. The drug is available in combinations such as Limbitrol Tablet (amitriptyline and chlordiazepoxide) and Anxipan (amitriptyline and pantoprazole).
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The global amitriptyline market is accounted to be valued around US$ 527.4 million in 2020 and is expected to register a CAGR of 5.3% over the forecast period (2020-2027).
Increasing concerns of migraine, neuropathic pain, and related disorders are expected to propel growth of the global amitriptyline market over the forecast period. For instance, in 2010, according to clinical evaluation study published in National Center for Biotechnology Information (NCBI), the estimated community prevalence of neuropathic pain from the clinical examination (gold standard) was 9.8%. This condition is more common in the geriatric population.
Furthermore, amitriptyline is an off-label, inexpensive and effective agent, which is useful for treatment of tension-type headache and migraine. For instance, in 2019, according to Migraine Research Foundation, migraine is the third most common disease in the world, and has affected around 39 million children, men and women in the U.S. and 1 billion globally.
The unbearable side effects of amitriptyline are affecting the need for medication, which is expected to hinder growth of the global amitriptyline market. Side effects of amitriptyline include vomiting, nausea, drowsiness, nightmares, weakness or fatigue, changes in sex drive, headache, constipation, dry mouth and more. Moreover, side effects of medication can change a patient’s preference for alternative therapies.
North America amitriptyline market is expected to register significant growth over the forecast period due to rising incidence of neuropathic pain around the U.S. population. For instance, in 2018, according to a study published in the Journal of Pain Research, the reported prevalence of neuropathic pain in the U.S. was 10%. Moreover, according to the National Institute of Neurological Disorders and Stroke (NINDS) report, 20 million Americans have some type of peripheral neuropathy.
- By Strength: 10 mg tablets, 25 mg tablets, 50mg tablets, 75 mg tablets, 100 mg tablets, 150 mg tablets.
- By Indication: Depression, Nocturnal Enuresis, Migraine, Chronic Neuropathic Pain, Others.
- By Distribution Channel: Hospital Pharmacies, Retail Pharmacies, Online Pharmacies
Key players are dominating in the global amitriptyline market including Accord Healthcare Inc., Sandoz Inc., Mylan Pharmaceuticals Inc., Sun Pharmaceutical Industries Inc., Zydus Pharmaceuticals USA Inc., Vintage Pharmaceuticals Inc., Torrent Pharmaceuticals Ltd., and Watson laboratories Inc.
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