Global ADME (Absorption, Distribution, Metabolism and Elimination) Toxicology Testing Market
Toxicology testing is a process of identifying the extent to which an agent of interest negatively affects the normal biochemical processes of an individual organism, given a particular exposure period, route of entry, and specific substance concentration. A wide variety of toxic agents have been identified over the years, from fertilizers and household cleaners to pesticides and industrial chemicals. In most cases, toxicologists are employed only after an initial clinical diagnosis has been made and toxic agents have been identified and tested. Clinical toxicology is the field of medicine that deals with the effects toxic substances have on living tissues and organs. The major units involved in toxicology include the lymphatic system, the immune system, the liver, the lungs, the blood, and the skin. Although toxicologists can use any methods they deem appropriate for their particular diagnosis, they generally follow established procedures and reporting guidelines from various associations and groups.
Toxicology testing is usually performed on patients who have been pronounced deceased at the scene of the incident, but may be responsive to inhalation or ingestion of contaminated fluids. The preferred method of toxicology testing is direct serum enzyme-linked immunosorbent assay (DSA-ELISA). In this procedure, a panel of specific antigens is incubated with enzyme in a complex buffer, enclosed within a semi-permeable filter paper, for 24 hours. Samples are drawn at regular intervals and analyzed for levels of assigned antigens, and any abnormalities in the test subjects that may suggest toxicological links to the clinical specimens.
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Recent Developments:
Major players operating in the global ADME (absorption, distribution, metabolism and elimination) toxicology testing market are focused on adopting M&A strategies to expand their product portfolio. For instance, in October, 2014, Wuxi Pharma Tech acquired Xenobiotic Laboratories, Inc. (XBL) to aid its bioanalytical, drug metabolism and pharmacokinetic and ADME services for radio-labeled compounds.
Similarly, in December, 2016, Evotec AG acquired Cyprotex PLC to enhance Evotec’s ADME-Tox platform, in vitro ADME screening, high-content toxicology screening and mechanistic and, predictive modeling.
Global ADME (Absorption, Distribution, Metabolism and Elimination) Toxicology Testing Market: Drivers
Increasing prevalence of chronic disorders is expected to propel growth of the global ADME (absorption, distribution, metabolism and elimination) toxicology testing market. For instance, according to the American Cancer Society, in 2019, there will be an estimated 1,762,450 new cancer cases diagnosed and 606,880 cancer deaths in the U.S.
Global ADME (Absorption, Distribution, Metabolism and Elimination) Toxicology Testing Market: Restraints
Lack of in-vitro models to detect autoimmunity and immune-stimulation is expected to limit growth of the global ADME (absorption, distribution, metabolism and elimination) toxicology testing market.
Global ADME (Absorption, Distribution, Metabolism and Elimination) Toxicology Testing Market: Competitive Landscape
Major players operating in the global ADME (absorption, distribution, metabolism and elimination) toxicology testing market include, Thermo Fisher Scientific, Inc., Caliper Life Sciences, Inc., Cyprotex PLC, Molecular Discovery Ltd., Bio-Rad Laboratories, Inc., Optivia Biotechnology, Inc., Cellartis AB, Promega Corporation, Agilent Technologies, Inc., Beckman Coulter, Inc.
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Global ADME (Absorption, Distribution, Metabolism and Elimination) Toxicology Testing Market: Key Developments
Major players operating in the global ADME (absorption, distribution, metabolism and elimination) toxicology testing market are focused on adopting M&A strategies to expand their product portfolio. For instance, in January, 2014, Cyprotex PLC, a specialist ADME-Tox CRO, announced to acquire CeeTox, Inc. to expand its portfolio in in-vitro toxicity assays and screening services.
Similarly, in September 2017, BioIVT acquired Qualyst Transporter Solutions, LLC, a provider of cell-based testing approach for in vitro hepatic models.
Global ADME (Absorption, Distribution, Metabolism and Elimination) Toxicology Testing Market: Taxonomy
- By Product:
- Instruments
- Assay Systems
- Software Solutions
- Reagents
- Others
- By Technology:
- In-silico Testing
- In-vitro Testing
- In-vivo Testing
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