SEATTLE, July 26, 2021, (MEDGADGET) — Global Janus Kinase Inhibitor Market – Insights
Janus kinase (Jak) is a non-tyrosine receptor kinase family that plays an important role in cytokine signaling. When cytokines (ligands) bind to receptors, they become demonized, which stimulates Jak-mediated phosphorylation of the receptor. STAT (Signal Transducer and Activator of Transcription proteins) is phosphorylated by Jak, and the STAT dimer is responsible for the transcription of genes implicated in the inflammatory and immunological response. As a result, Janus kinase is exploited as a therapeutic target for autoimmune diseases including rheumatoid arthritis.
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Because of their importance in immune response signalling, Jak inhibitors are becoming more popular in industrial research. In June 2018, Eli Lilly and Company announced that the US Food and Drug Administration (FDA) had approved OLUMIANT (baricitinib), an oral medicine for individuals with rheumatoid arthritis. Baricitinib was approved for use as a monotherapy or in combination with methotrexate (MTX) or other disease-modifying antirheumatic medicines (DMARDs). The medicine prevents the activation of Jak1/2 (Janus kinase 1 and 2) and the creation of inflammatory cytokines, therefore reducing inflammation. As a result, the worldwide Janus kinase inhibitor market is predicted to develop at a faster rate over the projected period due to the increased launch of new medications.
Psoriatic arthritis is an arthritic condition marked by red areas of skin covered with silvery scales. Tofacitinib is a Janus kinase inhibitor that regulates cytokines involved in inflammatory and immune response signaling. Over the forecast period, the worldwide Janus kinase inhibitor market is likely to rise due to the addition of new therapeutic options. Pfizer Inc., for example, got FDA approval for XELJANZ (TOFACITINIB) in December 2017 for the treatment of adult patients with psoriatic arthritis (PsA).
Furthermore, major pharmaceutical companies and research institutions are concentrating their efforts on the development of novel Janus kinase inhibitors. For example, M.D. Anderson Cancer Center conducted phase -2 clinical trials (research concluded in March 2017) in partnership with Incyte Corporation to assess the efficacy of ruxolitinib in the treatment of advanced hematological malignancies. Ruxolitinib is a Jak1 and Jak2 kinase inhibitor that stops altered cells from growing. As a result, the worldwide Janus kinase inhibitor market is likely to increase over the projected period due to active research and development of novel Janus kinase inhibitor medications.
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Over sixty cytokines use the Janus kinase pathway for intracellular signaling. Systemic lupus erythematosus (SLE) is an autoimmune condition and chronic disease characterized by inflammation of connective tissues such as cartilage and blood vessel lining caused by cytokine dysregulation. The highest frequency and incidence of SLE was documented in North America (23.2/100 000 people) between August 2013 and September 2016, according to the National Center for Biotechnology Information (NCBI). As a result, the high frequency of SLE in North America is likely to drive the market of Janus kinase inhibitors over the forecast period.
The Asia Pacific Janus kinase inhibitor market is likely to rise due to an increase in research and development initiatives for the launch of new medications. For example, Astellas Pharma Inc., a pharmaceutical firm based in Japan, undertook a Phase 3 clinical trial of the medication Peficitinib for the treatment of rheumatoid arthritis (which was finished in November 2017). The goal of the trial was to see if Peficitinib, alone or in combination with disease-modifying antirheumatic medications (DMARDs), was superior than DMARDs in patients with rheumatoid arthritis who did not respond well to DMARDs. Peficitinib is a Jak 1 and Jak inhibitor that reduces T cell proliferation and STAT5 phosphorylation in Interleukin 2 dependent T cells. These factors are projected to boost the worldwide Janus kinase inhibitor market’s growth.
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The market is projected to be hampered by regulatory obstacles in the launch of Janus kinase inhibitors. For example, the United States Food and Medicine Administration (FDA) asked Eli Lilly & Company to produce additional clinical data for the dosing of the drug Olumiant in April 2017 in order to describe safety risks. Due to safety concerns about arterial and venous thrombosis, the FDA refused the company’s application for a 4mg once daily dose of Olumiant in April 2018.
Table of Content
Global Janus Kinase Inhibitor Market Research Report
Section 1: Global Janus Kinase Inhibitor Industry Overview
Section 2: Global Economic Impact on Janus Kinase Inhibitor Industry
Section 3: Global Market Competition by Industry Producers
Section 4: Global Productions, Revenue (Value), according to Regions
Section 5: Global Supplies (Production), Consumption, Export, Import, geographically
Section 6: Global Productions, Revenue (Value), Price Trend, Product Type
Section 7: Global Market Analysis, on the basis of Application
Section 8: Janus Kinase Inhibitor Market Pricing Analysis
Section 9: Market Chain, Sourcing Strategy, and Downstream Buyers
Section 10: Strategies and key policies by Distributors/Suppliers/Traders
Section 11: Key Marketing Strategy Analysis, by Market Vendors
Section 12: Market Effect Factors Analysis
Section 13: Global Janus Kinase Inhibitor Market Forecast
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