SEATTLE, May 18, 2021, (MEDGADGET) — Overview
The prepacked chromatography columns are widely used in bio-pharmacy industry along with protein purification and molecule separation applications. According to the application such as process development, preparative chromatography, high throughput screening, and bench-scale screening.
Statistics
By 2027, the global prepacked chromatography columns market is projected to have a valuation of US$ 4,263.5 million.
Drivers
Launch of newer biopharmaceutical drugs and rising research and development work to develop such drugs, are expected to boost growth of the global prepacked chromatography columns market during the forecast period. As per the Pharmaceutical Research and Manufacturers of America, U.S., around 750 drugs were approved in 2018 as compared to 600 orphan drugs in 2017.
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Furthermore, rising demand of purification in biopharmaceuticals is expected to augment growth of the global prepacked chromatography columns market. Bio-pharmaceutical drugs need a considerable purity, which makes the downstream process a crucial stage in the overall process. Purification and screening play a vital part in the production of bio-pharmaceutical drugs.
Statistics
In 2019, the North American region held a dominating position in the global prepacked chromatography columns market, contributing about 33.3% of market share and was followed by Asia Pacific and European regions, respectively.
Restraints
Clogging and fouling in prepacked chromatography columns are expected to hinder growth of the global prepacked chromatography columns market. Clogging and fouling can lead to rise in pressure-drop over the columns and also reduce the dynamic binding capacity. This further leads to reduction in life expectancy of the columns. Back flush can be done from axial flow to reverse clogging and fouling, but it cannot be carried out in radial flow.
Furthermore, higher priority to traditional chromatography columns in developing countries and the higher maintenance cost associated with reusable pre-packed chromatography columns, are expected to hamper growth of the global prepacked chromatography columns market.
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Opportunities
Rising R&D activities on bio-similars is expected to provide robust growth opportunities for companies operating in the global prepacked chromatography columns market. In May 2018, an American pharmacy company, Pfizer, Inc., had received the approval from U.S. FDA for RETACRIT, a biosimilar of Procrit and Epogen. RETACRIT is the only biosimilar erythropoiesis-stimulating agent which has been approved by FDA.
Furthermore, development of bigger, single-use, low-cost, prepacked columns for commercial and large scale clinical applications is expected to stimulate growth of the global prepacked chromatography columns market.
Statistics
In 2019, the global prepacked chromatography columns market had a valuation of US$ 2,227.4 million and is expected to attain a valuation of US$ 4,263.5 million by 2027 with a CAGR of 8.5% over the forecast period (2020-2027).
Key Takeaways
Pre-packed columns of less than 1L are being developed to accommodate economic, logistical, and technical benefits. Comparatively, larger pre-packed columns can be cleaned, set-up, and validated easily. Large columns can minimize the amount of time and work needed for maintenance, increase productivity, and provide flexibility in operations with quick change-overs for its users.
Increased adoption of multimodal chromatography columns due to selectivity improvement which is achieved while separation of proteins through these columns as compared to conventional single-mode chromatography. These columns can be used for making drugs that require proteins and cannot be separated easily from impurities. This technique finds its application in downstream processing of monoclonal anti-bodies.
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Competitive Landscape
Key companies contributing in the global prepacked chromatography columns market are GE Healthcare, Pall Corporation (Danaher Corporation), Agilent Technologies Inc., EMD Millipore (Merck KGaA), Agela Technologies (Danaher Corporation), Thermo Fisher Scientific, Inc., Repligen Corporation, Bio-Rad Laboratories, Inc., Phenomenex, Inc., and KNAUER Wissenschaftliche Geräte GmbH.
Key Developments
The focus of key players operating in the market on adopting strategies of collaborations to increase their share in market. In January 2020, Agilent Technologies Inc., had partnered with IIT (Indian Institute of Technology), Delhi, India to enhance bio-pharmaceutical research.
The focus of key players operating in the market on adopting strategies of mergers and acquisitions to broaden their portfolio of products. In April 2019, Repligen Corporation had acquired C Technologies, Inc., in an agreement to extend its Process Analytics segment of bio-processing.
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