Protein A is a 42 kDa surface protein, which is found in the cell walls of bacteria Staphylococcus aureus. Protein A is a bacterial protein that can bind mammalian antibodies of class immunoglobulin G with great affinity. Protein G binds to all subclasses of human immunoglobulin G (IgG), which is further used for purifying polyclonal or monoclonal IgG antibodies whose subclasses have not been determined. Monoclonal antibody is an antibody that produced by a single clone of cells. It can be used to carry drugs, toxins, or radioactive substances traditional to cancer cells. Monoclonal antibodies have been used in the management of chronic diseases such as cancer and rheumatoid arthritis and has shown promising results. Moreover, they are crucial in purification and separation materials due to high resolution, across the biopharmaceutical industry. Today, protein A is produced from Escherichia coli, while it is naturally produced from Staphylococcus aureus. Chromatography with these has several advantages as a separation method, over conventional techniques such as solvent extraction, crystallization, and distillation.
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Market Dynamics- Drivers
Growing application of monoclonal antibodies in diagnostic and therapeutic application in management of chronic diseases such as cancer, rheumatoid arthritis is expected to drive growth of the global protein A resins market over the forecast period. Moreover, high selectivity and enhanced antibody production along with ease of operation in large and small scale antibody purification and immunoprecipitationis expected to fuel the global protein A resins market growth. Increasing government initiatives to support formulation of suitable policies for startups and administration of funding for development of next-gen medical products are expected to drive the market growth in the near future. Development of cost effective protein A resin is also expected to boost growth of the market.
Global Protein A Resin Market
On the basis of Product, the global protein A resin market is classified into:
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- Natural Protein A Resin
- Recombinant Protein A Resin
On the basis of Application, the global protein A resin market is classified into:
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- Immunoprecipitation
- Antibody Purification
On the basis of Matrix Type, the global protein A resins is classified into:
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- Glass or Silica
- Agarose and
- Organic Polymer
On the basis of end-users, the global protein A resins is classified into:
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- Biopharmaceutical Manufacturers
- Clinical Research Laboratories and
- Academic Institutions
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Market Dynamics- Regional Insight
Among regions, North America held the largest share in the global protein A resin market. This is owing to ongoing clinical trials for the monoclonal antibody-based therapeutics and increasing use of biosimilars with the recent U.S. Food and Drugs Administration (FDA) in the region. In North America, the U.S. accounted for the largest revenue share in the region. The country is expected to maintain its dominance over the forecast period. Asia Pacific is expected to witness significant growth during the forecast period. This is owing to increasing compliance for biosimilars and rising trend for expanding biopharmaceutical manufacturing capacities in emerging economies of the region.
Increasing awareness about random methods to purify monoclonal antibodies is obstructing the Protein A Resins market. High costs associated with the Protein A resins is also a major factor restraining the market growth. Geographic expansion, agreements, strategic acquisitions, and continuous effort to improve the product assortment are the key strategies adopted by the market players to stand the competitive market.
Growing demand for early detection and prevention of curable diseases, typically in adults is expected to drive growth of the market during the forecast period. This is due to rapidly increasing adult population. Moreover, increasing demand for safe and valuable treatments is expected to propel growth of the market in the near future. This is owing to unmet medical needs among patients with sickle cell anemia.
Key players operating in the global protein A resin market are Thermo Fisher Scientific Inc., General Electric Company, Merck KGaA, Repligen Corporation, Tosoh Corporation, Expedeon Ltd., Novasep, and GenScript.
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Key Developments
- Key companies in the market are focused on various growth strategies such as product launches, in order to expand their product portfolio. For instance, in September 2017, GE Healthcare, a U.S.-based healthcare company, launched protein A chromatography resin. The company also announced to invest around U$ 70 million a year over each of the next five years to produce it.
- Key players in the market are involved in various growth strategies such as product launches, in order to expand their product portfolio. For instance, in June 2018, Purolite Life Sciences, a provider of pharmaceutical applications, launched new-generation protein A agarose resin ‘Praesto Jetted A50’. This new resin is a combination of jetting technology and high performance protein A ligand.
- Major companies in the market are involved in various business strategies such as partnership and collaboration, in order to enhance their market presence. For instance, in November 2017, Purolite Life Sciences collaborated with Repligen Collaboration, a life sciences company, to provide Purolite customers with end-to-end solutions for downstream purification of biologic drugs, particularly monoclonal antibody-based biologics.
Table of Content
Global Protein A Resin Market Research Report
Section 1: Global Protein A Resin Industry Overview
Section 2: Global Economic Impact on Protein A Resin Industry
Section 3: Global Market Competition by Industry Producers
Section 4: Global Productions, Revenue (Value), according to Regions
Section 5: Global Supplies (Production), Consumption, Export, Import, geographically
Section 6: Global Productions, Revenue (Value), Price Trend, Product Type
Section 7: Global Market Analysis, on the basis of Application
Section 8: Protein A Resin Market Pricing Analysis
Section 9: Market Chain, Sourcing Strategy, and Downstream Buyers
Section 10: Strategies and key policies by Distributors/Suppliers/Traders
Section 11: Key Marketing Strategy Analysis, by Market Vendors
Section 12: Market Effect Factors Analysis
Section 13: Global Protein A Resin Market Forecast
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