Hematopoietic stem cell transplantation (HSCT) involves intravenous infusion of autologous or allogeneic stem cells that are collected from bone marrow, umbilical cord, or peripheral blood. This is done to reestablish hematopoietic function in patient whose immune system or bone is damaged or defective. Hematopoietic stem cell transplantation finds major applications in the treatment of lymphoma (Hodgkin and Non-Hodgkin), leukemia, multiple myeloma, thalassemia, sickle cell anemia, and osteoporosis. It includes two transplantation sources namely, autologous that uses stem cells from the patient’s own body and allogeneic that sources stem cells from a donor’s body. According to World Health Organization (WHO), over 50,000 hematopoietic stem cell transplantation procedures are carried out globally, every year and this number is expected to increase over the years.
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Market Dynamics- Drivers
Increasing occurrence of leukemia and lymphoma and constant research on hematopoietic stem cells are expected to drive growth of the global hematopoietic stem cell transplantation market during the forecast period. According to 2019 report by Leukemia and Lymphoma Society, around 176,200 individuals in the U.S. are estimated to be diagnosed with leukemia, lymphoma or myeloma and around 1,399,180 individuals are living with leukemia, lymphoma or myeloma in the U.S. Moreover, growing awareness regarding stem cell therapies among the population is expected to propel the global hematopoietic stem cell transplantation market growth over the forecast period. According to the Center for International Blood and Marrow Transplant Research reports nearly 101,433 Search Results hematopoietic cell transplantation were carried out in the U.S. between 2012 and 2016, which indicates potential opportunities for market players.
Market Dynamics- Restraints
High costs of hematopoietic stem cell transplantation procedures is expected to restrain growth of the global hematopoietic stem cells transplantation market in the near future. Moreover, factors such as difficulty in finding a donor for allogeneic transplantation, technological barriers (currently used culture technologies, point of care delivery, and lack of analytical assay), and side effects such as graft vs. host disease, are also expected to hamper the global hematopoietic stem cell transplantation market.
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Global Hematopoietic Stem Cell Transplantation Market Taxonomy
On the basis of indication:
- Leukemia
- Lymphatic disorder
- Myeloma
- Other non-malignant disorders (thalassemia, sickle cell anemia, Osteoporosis, Immunodeficiency syndrome)
On the basis of application:
- Peripheral blood cells
- Bone marrow
- Umbilical cord blood
Furthermore, increasing adoption personalized medicine is expected to drive growth of the global hematopoietic stem cells transplantation market over the forecast period. A collaborative research study on hematopoietic stem cell transplantation initiated by World Network for Blood and Marrow Transplantation (WBMN) in 2013 in the domain of promotion of access to hematopoietic stem cell transplantation, developed a donation guidance document, technical and scientific input on safety, and quality of HSCT as mentioned in annual report of the WBMN.
In March 2017, Gilead Sciences announced the acquisition of Kite Pharma, which produces products such as Axi-cel to treat non-Hodgkin lymphoma. Plasticell, which specializes in the development of stem cell technologies and cell-based therapies, announced entering into an agreement with Nan yang Technological University (NTU) in Singapore on March 2017, to advance its therapeutic stem cell pipeline. Plasticell also announced collaboration with Anthony Nolan, a research organization in blood cancer, to progress clinical development of Plasticell’s ex vivo expanded cord blood-derived hematopoietic stem cell product in December 2017. Also, GE Healthcare announced the introduction of Thaw CB1000, for thawing large volumes of cell therapies cryopreserved in cryo-bags majorly intended for use in research laboratory, in September 2017.
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Furthermore, increasing strategic collaboration between leading players operating in the market is expected to propel the growth of the market during the forecast period. For instance, on January 2019, Gamida Cell Ltd. a leading cellular and immune therapeutics company, and Lonza entered into a strategic manufacturing agreement for commercial production after potential FDA approval of omidubicel, currently in clinical development designed to enhance the life-saving benefits of hematopoietic stem cell (bone marrow) transplant.
Important players present in the global hematopoietic stem cell transplantation market
Major players operating in the global hematopoietic stem cell transplantation market are Pluristem Therapeutics Inc., CellGenix Technologie Transfer GmbH, Kite Pharma Inc., Regen Biopharma Inc., BiolineRx, Cynata Therapeutics, Lonza Group Ltd, Cesca Therapeutics Inc., TiGenix N.V., Escape Therapeutics Inc., Bluebird Bio, and Cellular Dynamics International.
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