Impact Analysis of Covid-19
The complete version of the Report will include the impact of the COVID-19, and anticipated change on the future outlook of the industry, by taking into the account the political, economic, social, and technological parameters.
Cell-free proteins are produced with the utilization of numerous kinds and species of cell lysates, which are known to offer various advantages over conventional in vivo methods, such as rapid and high-throughput expression process, no requirement of extensive protein purification, isotopic labeling of proteins, and production of functional virions or toxic polypeptides.
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The global cell-free protein expression market is estimated to garner up to US$ 318.9 million, in terms of value, by the end of 2027. Escalating demand for cell-free protein expression in the fields of proteomics and biologics is one of the most vital factors bolstering the growth of the global cell-free protein expression market currently. The simple presentation of the cell-free protein expression system aids in its easier integration into high-throughput platforms for efficient biologics and proteomics studies. Additionally, these systems allow the combination of various natural and unnatural components with the reaction mixture, such as reducing/oxidizing elements, chaperones, labeled amino acids, or detergents, by virtue of which this system makes for the appropriate choice for different proteomics studies.
Cell-free protein expression systems find application in the extensive R&D of neurological disorders, which acts as a significant factor providing the global cell-free protein expression market with ample growth prospects. For instance, in January 2018, researchers from European Molecular Biology Laboratory, the University of New South Wales, and the University of Queensland, reported the use of the cell-free protein expression system is the assessment of the effect of β-synuclein (a protein encoded by the SNCB gene) on the aggregation of five α-synuclein pathological mutants linked to the early-onset Parkinson’s disease.
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However, the lack of eukaryotic co- and post-translational modifications is expected to impede the growth of the global cell-free protein expression market in the near future. Such a factor could further result in low protein yield, as well as increased production costs.
Key Market Takeaways:
Cell-free protein expression systems have considerably advanced over the past decades, which in turn, has led to their wide usage in in-vitro protein production in laboratories. The continuous expression mode for protein synthesis, especially in wheat germ lysates, is being highly accepted for production in industrial scale. Therefore, these methods help produce proteins of high commercial value, such as hormones, diagnostic enzymes, and vaccines, with a higher level of purity.
The E.coli Cell-free Protein Expression System segment was valued at US$ 88.6 million in the global cell-free protein expression market in 2019. Increasing demand for cell-free protein expression in proteomics and biologics creates a conducive environment for the growth of this segment during the forecasted timeline. Furthermroe, the Protein Purification segment dominated the global cell-free protein expression market in 2019, accounting for an incredible 38.9% market share, in terms of value.
The leading players operating in the global cell-free protein expression market include Thermo Fisher Scientific, Inc., Takara Bio, Inc., Promega Corporation, New England Biolabs, Jena Bioscience GmbH, GeneCopoeia, Inc., Cube Biotech GmbH, CellFree Sciences Co., Ltd., Moderna Therapeutics, Biotechrabbit GmbH, and Bioneer Corporation.
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Key Market Developments:
In January 2020, Takara Bio Inc. announced the establishment of a new facility in Japan, called the Center for Gene and Cell Processing II, for the research and manufacturing of regenerative medicine products. Hence, in July 2018, Moderna Therapeutics, a clinical-stage biotechnology company, announced the launch of its state-of-the-art manufacturing facility in Norwood, Massachusetts (U.S.).
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