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The global avascular necrosis market was valued at US$ 512.9 million in 2017, and is projected to record an impressive CAGR of 6.0% over the forecast period (2018-2026).
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Avascular necrosis is a condition occuring when the blood flow to the head of thighbone is reduced or stopped, and is said to result in the death of cells of bone tissue in most cases. There is no known pharmaceutical cure for permanent cure of avascular necrosis. Various combinations of non-operative treatments are known to reduce symptomatic pain, such as electrical stimulation, hyperbaric oxygen therapy, shock wave therapy, physiotherapy, pharmaceuticals (such as bisphosphonates, anticoagulants, vasodilators, and lipid lowering agents), and muscle strengthening exercises.
Core decompression, osteotomies, bone and cartilage grafting, and total hip replacement surgery are the common operative treatments for avascular necrosis. Biopsy is a conclusive way to diagnose avascular necrosis but is rarely used as it requires surgery. Recovery and rehabilitation of avascular necrosis depends on surgical treatment used. Osteotomies limit activity for few months, however, a total hip replacement allows patients to begin walking with support, within days.
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The progression of avascular necrosis can be delayed with the help of early diagnosis and treatment, which further minimize the need for costly and invasive procedures. According to the Chinese Medical Journal 2015 study, direct cost to patients for undergoing primary total hip arthroplasty per hip without revision is between US$ 8000 and US$ 10,000 in China. The key market contenders have been focusing on the development of effective and inexpensive therapies for treating this condition. For instance, Bone Therapeutics and Enzo Biochem, Inc. focuses on gene regulation and cell-based product treatment, which is expected to increase avascular necrosis market revenue.
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- As per the 2015 data compiled by the National Organization for Rare Disorders, avascular necrosis is one of the rarest diseases in the world, which is known to affect at least one of every 2,000 people.
- Asia Pacific is anticipated to emerge as the most prominent region in the global avascular necrosis market over the forecast timeline, on account of the high prevalence of non-traumatic avascular necrosis of femoral head in the region. According to the Clinical Orthopedics and Related Research, 2010, about 2500 to 3300 new cases of non-traumatic avascular necrosis of the femoral head are reported in Japan annually.
- The renowned companies operating in the global avascular necrosis market include Bone Therapeutics, Boehringer Ingelheim GmbH, Bayer AG, Enzo Biochem Inc., Ethicon Inc., Eli Lilly and Company, Grifols SA, Integra LifeSciences Corporation, K-Stemcell Co Ltd., Medtronic Plc, Merck KGaA, Pfizer Inc., Sanofi SA, Stryker Corporation, Wright Medical Group N.V., and Zimmer Biomet Holdings.
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