- “Global CRISPR Cas9 Market, Clinical Trials & Therapeutic Application Outlook 2024” Report Highlight:
- Global CRISPR Cas9 Market Overview
- Global CRISPR Cas9 Clinical Trials: 43 Therapies
- Global CRISPR Cas9 Clinical Trials by Company & Indication
- Global CRISPR Cas9 Market Regional Scenario
- Global CRISPR Cas9 Therapy Application by Multiple Indications
- Key Companies Profile Involved In Clinical Trials: 12 Companies
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For Report Sample: neeraj@kuickresearch.com
CRISPR technology is one of the most advanced technology falling under the category of gene editing. It stands out as a mature existing system that can be used to engineer the genes with the desired ones. CRISPR contains innovative capabilities making its potential benefits endless. Till now, the theoretical knowledge about CRISPR has gained much attention and now it’s the time for us to apply it for the practical use.
CRISPR-Cas9 technology has dominated all the other technologies that have been widely used for the gene editing purpose. CRISPR, a prokaryotic defense mechanism is suppressing the entire available gene editing system used in eukaryotic system. Increase funding on the CRISPR research has upregulated the potential benefits received from it. Many other factors are also responsible for the growth of the market worldwide. Some of these includes: increasing demand of drug discovery, increasing size of geriatric population, changing lifestyles, prevalence of genetic disorders, growing awareness regarding gene therapeutics, investment in path-breaking research technology.
North America dominates the significant market of CRISPR. North America due to its advanced technologies is witnessing a robust growth of the CRISPR based technologies. The market in North America is driven by the presence of leading manufacturers in the area whereas increased cases of the health related problems, favorable funding scenario for research and development in the field of genetic engineering, increasing awareness of the technology, proximity of the companies and early adoption of latest technologies. It is expected that North American market will account for the largest share of the CRISPR gene editing market in the upcoming years also.
Europe has also emerged as another dynamic market for development and expansion of CRISPR technology. There is a continuous investment from the companies from Germany, Switzerland and other European countries for the research and development on the CRISPR based tools. The growth of CRISPR technology in Europe is primarily attributed to the rise in the advancements of different technologies in gene editing technique. The research and development department in Europe is making high efforts to establish the unseen potential benefits from CRISPR technology. The scope for the consumer genomics is adding a positive effect on the growth of CRISPR market in the upcoming years.
- Introduction to CRISPR-Cas9
1.1 Overview
1.2 History of CRISPR-Cas9 Technology
- Mechanism of Action
2.1 Immune Defense with CRISPR in Single Celled Microorganisms
2.2 CRISPR Technology
- Delivery Methods for CRISPR-Cas9
3.1 Delivery of CRISPR-Cas9 components through Physical Methods
3.1.1 Microinjection
3.1.2 Electroporation
3.1.3 Hydrodynamic Delivery
3.2 Delivery of CRISPR-Cas9 Components through Viral Vectors
3.2.1 Adeno-Associated Virus (AAV)
3.2.2 Lentivirus & Adenovirus
3.3 Delivery of CRISPR-Cas9 Components through Non-Viral Vectors (Biomaterials)
3.3.1 Liposomes
3.3.2 Gold Nanoparticles
3.3.3 DNA Nanoclew
- CRISPR-Cas9: A Home to a Variety of Applications
4.1 Advantages Accompanying CRISPR-Cas9 Technology
4.2 CRISPR-Cas9 Comparison with other Genome Editing Tools
- Global CRISPR-Cas9 Clinical Trials by Company & Indication
5.1 Research
5.2 Preclinical
5.3 Phase-I
5.4 Phase-I/II
5.5 Phase-II
- Global CRISPR-Cas9 Market Current Overview
6.1 Global CRISPR Market Analysis
6.2 Global CRISPR Market Regional Scenario
- Elimination of Genetic Disease: Sickle-Cell Anemia through CRISPR-Cas9
7.1 Overview
7.2 Sickle Cell Treatment with CRISPR
7.3 Clinical Trial for Testing CRISPR against Sickle Cell Anemia
- Revolutionizing the Treatment of Beta-Thalassemia
8.1 Overview
8.2 CRISPR Application in Treating Beta-Thalassemia
8.3 CRISPR Clinical Trial for Beta-Thalassemia
- Potential for Curing Cancer
9.1 Overview
9.2 CRISPR-Cas9 Fight for Cancer
9.3 CRISPR Trial for Cancer Treatment Research
- CRISPR-Cas9: A Step Closer to Treat Huntington’s Disease
10.1 Overview
10.2 CRISPR-Cas9 Towards Huntington’s Disease
10.3 CRISPR Mediated Treatment of Huntington’s Disease in Mouse Models
- CRISPR-Cas9 Technique to Reverse Obesity Epidemic (Type 2 Diabetes)
11.1 Overview
11.2 CRISPR Treatment for Obesity
11.3 Clinical Trials for Reducing Obesity Using CRISPR
- CRISPR-Cas9 Treatment for Cholesterol
12.1 Overview
12.2 Expanding the Application of CRISPR for Cholesterol
12.3 Lab Clinical Studies Reflecting the Positive Side of CRISPR
- CRISPR-Cas9 Against Malaria
13.1 Overview
13.2 CRISPR-Cas9 Technology for Malaria Treatment
13.3 Mosquitoes Carrying Parasites Eliminated using CRISPR-Cas9
- CRISPR-Cas9 for Knocking Out Cystic Fibrosis
14.1 Overview
14.2 CRISPR-Cas9: A Versatile Tool for Deactivating CFTR
14.3 Development & Research: CRISPR-Cas9
- CRISPR-Cas9 for the Removal of Hepatitis B
15.1 Overview
15.2 CRISPR-Cas9 Rising against cccDNA
15.3 Clinical Lab Studies Clears HBV cccDNA on Human Cell Lines
- Permanent Cure for HIV/AIDS Treatment
16.1 Overview
16.2 CRISPR-Cas9 for Deleting CCR5 Gene
16.3 Clinical Results Achieved Using CRISPR-Cas9 for HIV/AIDS
16.4 Gene-Edited Babies: HIV resistant
- CRISPR Hope for Alzheimer’s Disease
17.1 Overview
17.2 CRISPR-Cas9 for Alzheimer’s Disease
17.3 Lab Clinical Studies for Eliminating Alzheimer’s
- CRISPR-Cas9 to Correct Duchenne Muscular Dystrophy (DMD)
18.1 Overview
18.2 CRISPR-Cas9 Technology Over-Powering DMD Gene
18.3 CRISPR Success in Treating DMD in Mice Models
- CRISPR Enhances the Reach of Immunotherapy
19.1 CRISPR for Immunosuppressive Defects
19.2 CRISPR Mediated Generation of CAR-T Cells
- Global CRISPR-Cas9 Market Dynamics
20.1 Market Drivers for CRISPR-Cas9 Therapy
20.2 Challenges Overpowering CRISPR
- Global CRISPR-Cas9 Market Future Outlook
- Competitive Landscape
22.1 Beam Therapeutics
22.2 Casebia Therapeutics
22.3 CRISPR Therapeutics
22.4 EdiGENE Corporation
22.5 Editas Medicine
22.6 Emendo Biotherapeutics
22.7 Intellia Therapeutics
22.8 Modalis Therapeutics
22.9 Neon Therapeutics
22.10 Refuge Biotechnologies
22.11 Sarepta Therapeutics
22.12 Vertex Pharmaceuticals
List of Figures
Figure 1-1: Key Events in the History of CRISPR-Cas9 System Development
Figure 2-1: CRISPR Immune Mechanism in Bacteria
Figure 2-2: CRISPR Technology Working in Cell Lines
Figure 3-1: Delivery Methods for CRISPR-Cas9
Figure 3-2: Delivery Pathways for CRISPR-Cas9 Components
Figure 3-3: Physical Mode of Delivery for CRISPR-Cas9 Components
Figure 3-4: Viral Mode of Delivery for CRISPR-Cas9 Components
Figure 3-5: Non-Viral Mode of Delivery for CRISPR-Cas9 Components
Figure 4-1: Advantages of CRISPR-Cas9 Technology
Figure 4-2: Comparison between Different Genome Editing Tools
Figure 5-1: Global – CRISPR-Cas9 Clinical Trials by Phase (%), 2019 till 2024
Figure 5-2: Global – CRISPR-Cas9 Clinical Trials by Phase (Number), 2019 till 2024
Figure 6-1: Global – CRISPR Investments (US$ Million), 2011 & 2016
Figure 6-2: Global – Research Papers Published, 2011 & 2016
Figure 6-3: Global – CRISPR Market Size (US$ Million), 2018 – 2024
Figure 7-1: Normal RBCs VS Sickle Shaped RBCs
Figure 7-2: Treatment of Sickle Cell Anemia through CRISPR-Cas9
Figure 7-3: Phases Involved in a Clinical Trial of a Drug
Figure 8-1: Mutated Gene leading to Beta-Thalassemia
Figure 8-2: CRISPR-Cas9 Therapy for Beta-Thalassemia
Figure 9-1: Difference between Normal Cells & Cancer Cells
Figure 9-2: CRISPR-Cas9 Treatment for Cancer
Figure 9-3: Ongoing Clinical Trials on CRISPR in Different Types of Cancer
Figure 10-1: Defective Genes Leading to
Figure 10-2: CRISPR-Cas9 Technique for Huntington’s Disease
Figure 10-3: Experiment Conducted to Test CRISPR-Cas9 Effect on Transgenic R6/2 Mouse Model
Figure 11-1: Obesity Related Health Issues
Figure 11-2: Mutations Leading to Obesity
Figure 11-3: CRISPR-Cas9 Controlling Obesity
Figure 12-1: Cholesterol Pathways Present in the Body
Figure 12-2: Mutation Leading to Clogging of Arteries
Figure 12-3: CRISPR-Cas9 against Cholesterol
Figure 12-4: Experiment Conducted to Test CRISPR-Cas9 on Cholesterol Level
Figure 13-1: Malaria Transmission Cycle
Figure 13-2: CRISPR Cas9 Machinery against Malaria
Figure 13-3: Experiment Conducted to Test CRISPR against Plasmodium
Figure 14-1: CRISPR-Cas9 Correcting Cystic Fibrosis
Figure 14-2: Experiment Conducted on CF Patient to Evaluate CRISPR
Figure 15-1: HBV Virus Infecting Healthy Liver Cells
Figure 15-2: CRISPR Activity against Hepatitis B Virus
Figure 15-3: Experiment Showing Reduction in HBV Viral Proteins due to CRISPR
Figure 16-1: HIV Infection Leading to AIDS
Figure 16-2: CRISPR Knocking Out CCR5 Gene
Figure 17-1: APP Gene Mutation Leading to Alzheimer’s Disease
Figure 17-2: CRISPR-Cas9 Machinery for Alzheimer’s Disease
Figure 17-3: Strategies Adopted by Researchers to Treat Alzheimer’s Through CRISPR
Figure 17-4: Experiment Conducted to Test CRISPR for Alzheimer’s
Figure 18-1: DMD Gene Mutation Leading to Duchenne muscular Dystrophy
Figure 18-2: CRISPR-Cas9 Editing DMD Gene
Figure 18-3: Experiment Showing the Success of CRISPR in Treating DMD in Mice
Figure 19-1: Cancer Cells Escaping Immune
Figure 19-2: CRISPR Potential Activities
Figure 20-1: Key Drivers Leading to the Development of CRISPR
Figure 21-1: Future of CRISPR-Cas9 Gene Editing Technology
Global CRISPR Cas9 Market, Clinical Trials & Therapeutic Application Outlook 2024
October 7th, 2019 
Kuick Research Releases