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Disc Pump for Less Obtrusive Ambulatory Blood Pressure Systems

October 1st, 2019 Conn Hastings Anesthesiology, Cardiology, Diagnostics, Exclusive, Medicine

TTP Ventus, the UK-based developer of the Disc Pump, has recently begun working on a new application for this technology – ambulatory blood pressure systems. The company claims that the Disc Pump, which is a miniaturized, quiet, and highly efficient pump, could revolutionize ambulatory blood pressure measurements.

At present, 24-hour blood pressure monitors are commonly used to monitor blood pressure at regular intervals throughout the day and night. Such devices typically use motor-driven diaphragm pumps to inflate a cuff on the upper arm. However, these pumps are bulky and noisy, and affect airflow pulsation within the blood pressure monitor. This means that blood pressure measurements can only be taken after the cuff has been fully inflated and begins to deflate.

Taking measurements as the cuff inflates would be preferable, since the pressure the cuff would exert would not have to exceed systolic pressure by much, improving patient comfort and making night-time measurements less disruptive for sleeping users.

Conventional ambulatory blood pressure monitors also typically require a belt- or strap-worn pump unit, which is connected to a brachial cuff through a long hose. This is cumbersome, and the hose can become kinked and obstructed during sleep.

To address these issues, TTP Ventus has proposed that the Disc Pump could offer an alternative to motor-drive diaphragm pumps. The pump operates at over 20,000 cycles per second and moves less than a microliter of air during each cycle. This means that cuff pulsation is negligible during inflation, and blood pressure measurements can be obtained during this process. Moreover, because the pump is very small, it can be directly integrated into a brachial cuff, avoiding the need for cumbersome pump housing and a connecting hose.

See a video about the pump below.

Medgadget previously covered the Disc Pump in an interview with Tom Harrison, Business Development Manager of TTP Ventus about the role of the pump in the aerSleep system for obstructive sleep apnea. In this follow-up interview, we asked Tom about the potential of the Disc Pump in blood pressure monitoring systems.

Conn Hastings, Medgadget: Please give us an overview of current blood pressure monitoring systems, and their disadvantages.

Tom Harrison, TTP Ventus: Most current systems use a conventional, motor-driven pump to inflate a cuff worn on the arm. As the cuff squeezes the arm, the system makes careful measurements of the pressure oscillations resulting from the expansion and contraction of an underlying artery. Because conventional pumps tend to introduce pulsation whilst running, the pump needs to be turned off before the measurement process starts; therefore, current systems inflate the cuff to an upper pressure, before disengaging the pump and bleeding the pressure out with a valve.

This approach has drawbacks for user comfort and measurement integrity. First, the cuff must be inflated to well above systolic pressure (the higher of the two blood pressure measurements), applying significant forces to the arm. With the flow capacity of the pumps typically used, it can also take a little while to inflate the cuff meaning the arm is compressed for longer than you’d like. Both issues affect user comfort.

Furthermore, because conventional pumps tend to be large, noisy and to vibrate, manufacturers tend to design the pump to be worn on the belt or around the neck on a lanyard. Carrying around a bulky pump in this way is itself a drawback, particularly given that these systems are used for 24 hours at a time. Over that time, some measurements will necessarily happen whilst the patient is sleeping; clearly a noisy pump is a disadvantage here.

Another less obvious drawback is that the pump must be connected to the cuff via a hose. Any inadvertent pressure applied to this hose can interfere with the measurement; this is particularly relevant for measurements made during the night, where the hose is at greater risk of becoming kinked during sleep, or where the user may roll onto it.

Medgadget: How would the inclusion of the Disc Pump in such systems help to overcome these shortcomings?

Tom Harrison: Disc Pump has a number of unique features that, taken together, offer a substantial improvement for ambulatory blood pressure systems. First, unlike a conventional pump there is no pulsation in the output. This allows measurements to be made whilst the pump is running – and therefore, whilst the cuff is inflating. In turn, that means that the measurement can be completed as soon as the systolic condition is detected, i.e. the cuff needn’t be inflated any higher than necessary, minimizing the compression forces applied to the patient and therefore improving comfort.

Once the measurement has concluded, the cuff pressure can be rapidly vented with a valve. In principle this can be done much more quickly than the time taken to inflate the cuff with the conventional ‘measure on deflation’ approach. Therefore, the measurement duration can be minimized too.

Second, Disc pump is small and lightweight – it weighs around 5 g (1/4 oz) and is roughly coin-sized. Being this compact allows the pump (and electronics, battery, etc.) to be integrated into a small module mounted on the side of the cuff. That eliminates external tubing and the risks associated with obstructions. It also dispenses with the belt or lanyard-worn pump unit, improving the experience of the patient.

Third, the pump doesn’t emit any noticeable sound or vibration when operating, minimizing disruption to the patient – particularly during measurements at night.

Finally, the pump is precisely controllable, meaning that constant cuff inflation rates (either mmHg per second, or mmHg per heartbeat) can be easy maintained to ensure measurement accuracy.

Medgadget: What makes the pump different from traditional motor-driven diaphragm pumps?

Tom Harrison: Diaphragm pumps rely on the compression and expansion of gas within a confined space, thereby increasing altering its pressure. The pressure changes cause one-way valves to open, creating pumped flow. The motors (or in some cases, piezoelectric elements) and valves used by these pumps are limited in the frequency they operate at – typically no more than a few hundred cycles per second. At these frequencies, traditional pumps can generate substantial noise, vibration and a pulsatile flow of gas.

In contrast, Disc Pump does not rely on compression. Instead, it creates a high frequency, high amplitude standing wave and then rectifies that wave with an ultra-fast valve. Because Disc Pump operates at an ultrasonic frequency, it is completely silent and creates negligible pulsation and vibration.

What’s more, because Disc Pump doesn’t have a heavy motor (the whole device weighs only 5 grams), there is very little inertia – this means it can be turned on or off in a matter of milliseconds.

Finally, unlike a conventional pump, Disc Pump has no ‘stall’ speed. This means it can be driven at the very lowest levels without stopping.

Medgadget: Was it difficult to design and fabricate such a small pump, with such fine control?

Tom Harrison: One of the biggest challenges has been the design of the valve, to offer high performance and efficiency and yet robustness over the course of the pump’s operational life. On the one hand, the valve needs to respond in a few microseconds, which drives you towards using lightweight materials; on the other, over the course of its life operating 20,000 times per second, the valve will endure several hundred billion cycles. To put that in context, that’s roughly 20 cycles for every year the universe has existed. And that drives you towards looking at stronger materials and minimizing wear on them.

Certain aspects of the pump assembly require very precise tolerances, with some parts being aligned to a few microns’ accuracy – that’s around a tenth of the width of a human hair. We’ve combined largely conventional assembly processes as far as possible, customized only as necessary to meet our requirements.

Medgadget: Has the pump been integrated into a blood pressure monitor yet? If not, when do you expect that this will happen, and when might such devices be available for patients?

Tom Harrison: Not yet, although we have a number of customers working on it. Whilst the technical side is relatively straightforward, product development cycles like this often take several years and so I suspect such devices won’t be available to patients for a little while yet. 

Medgadget: What other medical applications has the pump been used for to date, and do you have any future plans for the pump?

Tom Harrison: All manner of interesting applications, from sleep apnea therapy, to breath-based disease diagnostics, compression therapy, microfluidics for point-of-care diagnostics and elevated vacuum prosthetics.

Our plans for the pump are focused on continuing to build on its success in the market. We’re working hard to reach new OEM customers across the medical and life science sectors, whilst keeping an eye on the emerging applications of tomorrow where the Disc Pump often adds significant value over conventional pumps. Our product pipeline is packed with a range of new models planned for release over the next year or so: these will push out the performance, efficiency and lifetime substantially, allowing us to support an ever-growing set of applications. The first of these new designs will be launched and on display at this year’s Compamed tradeshow in Düsseldorf.

Link: TTP Ventus homepage…

Flashback: aerSleep System for Obstructive Sleep Apnea (Interview)

Conn Hastings

Conn Hastings received a PhD from the Royal College of Surgeons in Ireland for his work in drug delivery, investigating the potential of injectable hydrogels to deliver cells, drugs and nanoparticles in the treatment of cancer and cardiovascular diseases. After achieving his PhD and completing a year of postdoctoral research, Conn pursued a career in academic publishing, before becoming a full-time science writer and editor, combining his experience within the biomedical sciences with his passion for written communication.

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