Description
This Market research report on G-Protein Coupled Receptors (GPCR) covers the types of GPCR Families and the various ligands targeting GPCR. The GPCR families covered include Rhodopsin, Secretin, Metabotropic glutamate and Other. The Ligands targeting GPCRs include Peptides or Proteins, Biogenic Amines, Lipids and Other. The report provides market analysis of each of the Families and ligands targeting GPCRs by their respective categories.
The study includes estimations and predictions for the total global GPCR Drug targets market and also key regional markets that include North America, Europe, Asia-Pacific and Rest of World. Historic, current and forecast markets (2010-2022) are illustrated graphically with 116 exhibits. Business profiles of 20+ major companies engaged in developing GPCR targeted drugs, GPCR cell lines and GPCR Assays are discussed in the report. The report serves as a guide to global GPCR – Drug Targets industry, covering more than 250 companies that are engaged in the development of GPCR Targeted Drugs, GPCR Assays Information related to recent product releases, Assay developments, partnerships, collaborations, and mergers and acquisitions is also covered in the report. Compilation of Worldwide Patents and Research related to GPCR Drug Targets is also provided.
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Highlights
GPCRs together with G-Proteins are known to have a very important role in physiology and diseases including diseases of the sense organs, digestive tract, endocrine system, and respiratory system and their processes. G-Proteins form a link between the cell surface receptors and the intracellular events by interacting with GTP. The phenomenon in which external stimuli bring about an expanding cascade of intracellular events culminating in specific cellular responses is called signal transduction.
The complex involved in this phenomenon consists of GPCR and G-Protein. This assembly is the most diverse among the cell surface receptors. Future progress may relate discoveries to the development of new medicines. At present the development of drugs is centered on the discovery of chemicals that influence the ability of the ligands to bind with the G-Protein Coupled Receptor or GPCR. This will either accelerate or inhibit the cellular process. In the in-depth studies pertaining to the G-Protein Coupled Receptor family, the role of chemical biology has been significant since the beginning. This is because the majority of the vital group of targets is for improvement in therapeutics. These receptors are defined by a common structural feature which is comprised of seven hydrophobic trans-membrane segments.
These proteins are also known as 7 TM, seven trans-membranes or serpentine receptors because in all cases the signaling through heterotrimeric G-Proteins is not exhibited. GPCRs are known to be attractive drug targets for several reasons. Firstly the location of the GPCRs on the cell surface makes them easy targets for the drugs. In addition, GPCRs are generally present everywhere as they play an important role in almost every system of the human body. As the human genome project is completed unknown functions of many of the genes expressing into GPCRs can be unraveled and thereby making them potential drug targets proteins in drug development.
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Key Players
ACADIA Pharmaceuticals, Inc. (USA)
Actelion Pharmaceuticals Ltd. (Switzerland)
Addex Therapeutics (Switzerland)
Arena Pharmaceuticals, Inc. (USA)
Cara Therapeutics, Inc. (USA)
Dimerix Bioscience Limited (Australia)
DiscoveRx Corporation (USA)
Domain Therapeutics SA (France)
EMD Millipore Corporation (USA)
Euroscreen SA (Belgium)
Exalpha Biologicals, Inc. (USA)
GPCR Consortium (USA/China)
GVK Biosciences Private Limited (India)
- Lundbeck A/S (Denmark)
Heptares Therapeutics (UK)
LifeSpan BioSciences, Inc. (USA)
Molecular Devices LLC (USA)
Omeros Corporation (USA)
PerkinElmer, Inc. (USA)
Receptos, Inc. (USA)
Takeda Pharmaceutical Co., Ltd. (Japan)
Trevana, Inc. (USA)
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Analytics and data presented in each report pertain to several parameters such as –
- Global and Regional Market Sizes, Market Shares, Market Trends
- Product (Global and Regional) Market Sizes, Market Shares, Market Trends
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- Corporate Intelligence
- Key Companies By Sales, Brands, Products
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