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Global Cancer Tubulin Inhibitors Market and Clinical Trial Insight 2024

February 6th, 2018 Kuick Research Releases

Download Sample

 

For Report Sample Contact: neeraj@kuickresearch.com

 

Report Weblink: https://www.kuickresearch.com/report-global-cancer-tubulin-inhibitors-market-and-clinical-trial-insight-2024.php

 

Table of Contents

 

1. Microtubules – Moving Target in Cancer Therapy

  1.1 Overview

  1.2 Tubulin Inhibitors for Cancer Treatment

    1.2.1 Microtubule Stabilizing Proteins

    1.2.2 Microtubule Destabilizing Proteins

2. Mechanism of Action and Mechanism of Resistance of Tubulin Inhibitors

  2.1 Mechanism of Action

  2.2 Mechanism of Resistance to Microtubule Binding Agents

3. Microtubules and Their Role in Cellular Stress in Cancer

  3.1 Tubulin Alterations in Cancer

    3.1.1 Changes in Tubulin Isotype Composition

    3.1.2 Tubulin Post Translational Modifications

    3.1.3 Microtubule Associated Proteins (MAP)

  3.2 Tubulin Cytoskeleton in Stress Response

4. Prognostic Role of Tubulin for Prediction of Cancer Aggressiveness

  4.1 Non Small Cell Lung Cancer

  4.2 Prostate Cancer

  4.3 Breast Cancer

  4.4 Colorectal Cancer

  4.5 Ovarian Cancer

5. Price and Dosage Analysis of Tubulin Inhibitor Drugs

  5.1 Docetaxel

  5.2 Trastuzumab Emtansine

  5.3 Abraxane

  5.4 Brentuximab Vedotin

  5.5 Cabazitaxel

6. Market Analysis of Tubulin Inhibitors

  6.1 Overview

  6.2 Global Sales of Tubulin Inhibitors Drugs

7. Global Cancer Tubulin Inhibitors Clinical Pipeline Overview

8. Global Cancer Tubulin Inhibitors Clinical Pipeline by Company and Phase

  8.1 Research

  8.2 Preclinical

  8.3 Clinical

  8.4 Phase-I

  8.5 Phase-II

  8.6 Phase-II/III

  8.7 Phase-III

  8.8 Preregistration

9. Marketed Cancer Tubulin Inhibitors Clinical Insight

  9.1 Docetaxel (Taxotere)

  9.2 Trastuzumab Emtansine (Kadcyla)

  9.3 Vinflunine (Javlor)

  9.4 Albumin-Bound Paclitaxel (Abraxane and Coraxane)

  9.5 Cabazitaxel (Jevtana)

  9.6 Brentuximab Vedotin (Adcetris)

  9.7 Paclitaxel Polymeric Micelle Formulation (Cynviloq and Genexol-PM)

  9.8 Paclitaxel Liposomal – Sun Pharma Advanced Research Company

  9.9 Paclitaxel Liposomal (Lipusu)

  9.10 Paclitaxel Nanoparticle (Nanoxel)

10. Global Cancer Tubulin Inhibitors Market Dynamics

  10.1 Favorable Market Parameters

  10.2 Commercialization Challenges

11. Future Perspective of Cancer Tubulin Inhibitors

12. Competitive Landscape

  12.1 Abraxis Biosciences

  12.2 Agensys

  12.3 Amgen

  12.4 Celgene

  12.5 Eagle Pharmaceuticals

  12.6 Endocyte

  12.7 Genentech

  12.8 Immunogen

  12.9 Modra Pharmaceuticals

  12.10 Pierre Fabre

  12.11 Roche

  12.12 Sanofi-Aventis

  12.13 Seattle Genetics

  12.14 Tocris Bioscience

 

 

Figure 1-1: Structure of Microtubule

Figure 1-2: Types of Tubulin Inhibitors for Cancer Treatment

Figure 3-1: Pathways for the Development of Cancer by Tubulin Alterations

Figure 3-2: Post Translational Modifications in Tubulin Structure

Figure 3-3: Structural Representation of Microtubule Associated Proteins

Figure 3-4: Tubulin Response to Cytoskeleton Stress

Figure 5-1: Docetaxel Drug Patent Approval and Expiry Year

Figure 5-2: Docetaxel Drug – Available Concentrations mg/ml

Figure 5-3: Docetaxel: Average Dosage Analysis in Breast Cancer Therapy (mg/m2)

Figure 5-4: Cost of Docetaxel Drug for the Concentration of 10 mg/ml, for 2 Milliliters, 8 Milliliters and 16 Milliliters, Respectively (US$), 2017

Figure 5-5: Cost of Docetaxel Drug for the Concentration of 20 mg/ml, for 1 Milliliters, 4 Milliliters, 8 Milliliters and 10 Milliliters, Respectively (US$), 2017

Figure 5-6: Cost of Docetaxel Drug for the Concentration of 40 mg/ml, for 0.5 Milliliters, and 2 Milliliters, Respectively (US$), 2017

Figure 5-7: Docetaxel Average Breast Cancer Treatment Cost (US$/Cycle), 2017

Figure 5-8: Docetaxel Average Lung Cancer Therapy Cost Analysis (US$/Cycle), 2018

Figure 5-9: Trastuzumab Emtansine Patent Approval and Expiry Year

Figure 5-10: Trastuzumab Emtansine: Average Dosage Analysis (mg/Dose)

Figure 5-11: Available Different Concentrations of Trastuzumab Emtansine (mg)

Figure 5-12: Trastuzumab Emtansine Price by Concentration (US$), 2017

Figure 5-13: Trastuzumab Emtansine: Vials Used in Metastatic Breast Cancer Treatment (By Number)

Figure 5-14: Trastuzumab Emtansine: Average Treatment Cost Analysis (US$), 2017

Figure 5-15: Abraxane: Patent Approval Year for Various Cancer Indications and Expiration Year

Figure 5-16: Abraxane Dosage Analysis by Indication (mg/m2)

Figure 5-17: Cost of Abraxane Intravenous Solution of 100 mg, US$

Figure 5-18: Abraxane: Cancer Treatment Cost Analysis per Cycle (US$), 2017

Figure 5-19: Brentuximab Vedotin Patent Approval and Expiry Years in US

Figure 5-20: Brentuximab Vedotin Patent Approval and Expiry Years in Europe

Figure 5-21: Price of Brentuximab Vedotin Drug for Per Vial of 50 mg and For 7 Cycles Treatment, (US$), 2017

Figure 5-22: US – Brenuximab Vedotin Price Analysis, (US$), 2017

Figure 5-23: US – Brenuximab Vedotin Treatment Expenditure (US$), 2014

Figure 5-24: US – Brenuximab Vedotin Treatment Cost (US$), 2017

Figure 5 25: Cabazitaxel: Price of Drug per Cycle in US$ and Patent Expiration Year

Figure 5-26: Cost of Jevtana Intravenous Solution and Per Unit Cost, US$, 2017

Figure 6-1: Global Sales of Docetaxel Drug (US$ Million), 2015 and 2016

Figure 6-2: Global -Trastuzumab Emtansine Sales Revenue, US$ Millions, 2013 and 2016

Figure 6-3: Global – Abraxane Sales US$ Million, 2014-2017*

Figure 6-4: Global – Brenuximab Vedotin Sales (US$ Million), 2014-2017

Figure 6-5: Global – Blinatumumab Half Yearly Sales (US$ Million), 2015-2017

Figure 6-6: Global – Sales of Cabazitaxel Drug, US$ million, 2015 andndash; 2017*

Figure 7-1: Global – Cancer Tubulin Inhibitors Clinical Pipeline by Phase (%), 2017 till 2024

Figure 7-2: Global – Cancer Tubulin Inhibitors Clinical Pipeline by Phase (Number), 2017 till 2024

Figure 7-3: Global – Cancer Tubulin Inhibitors Clinical Pipeline by Phase (%), 2017 till 2024

Figure 7-4: Global – Cancer Tubulin Inhibitors Clinical Pipeline by Phase (Number), 2017 till 2024

Figure 10-1: Favorable Market Parameters for Tubulin Inhibitors Development

Figure 10-2: Challenges to the Market Growth of Tubulin Inhibitors

 

 

 

Table 3-1: Clinical Studies of Tubulin Isotype in Drug Resistance

Table 5-1: Trastuzumab Emtansine Price Analysis

Table 5-2: Efficacy Results of Brentuximab Vedotin in Hodgkin Lymphoma Patients

 

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