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Global Cancer mTOR Inhibitors Market and Clinical Pipeline Outlook 2022

January 11th, 2018 Kuick Research Releases

For Report Sample Contact: neeraj@kuickresearch.com

 

Report Weblink:https://www.kuickresearch.com/report-global-cancer-mtor-inhibitors-market-and-clinical-pipeline-outlook-2022.php

 

Table of Contents

 

1. Mammalian Target of Rapamycin Inhibitors (mTOR) – The Future of Cancer Growth Blockers

  1.1 Preliminary Insight to mTOR Inhibitors

  1.2 History and Evolution of the mTOR Inhibitors

2. mTOR Signalling Pathway: Their Role and Significance in Cancer

  2.1 mTOR Signalling: A Vital Function in Cell Growth

  2.2 mTOR Signalling Pathway and Tumorigenesis

3. Principles of mTOR inhibitors in Cancer Therapy

  3.1 Activation of mTOR/pI3K pathway in Cancer

  3.2 Potential of mTOR as a Targeted Therapy

  3.3 Global – Cancer MTOR Inhibitors Clinical Pipeline Overview

4. Working Mechanism of mTOR Inhibitors in Cancer Therapy

  4.1 Effect of mTOR inhibitors in Cancer Cells

  4.2 Effects of mTOR inhibitors on Tumor Angiogenesis

5. Clinical Status and Application of mTOR inhibitors in Various Types of Cancer

  5.1 Breast Cancer

    5.1.1 HER2-Positive Breast Cancer

    5.1.2 HER-2 Negative Breast Cancer

  5.2 Hematological Malignancy

    5.2.1 Acute Myeloid Leukemia

    5.2.2 Chronic Myelogenous Leukemia

    5.2.3 Acute Lymphoblastic Leukemia

    5.2.4 Multiple Myeloma

     5.2.5 Lymphoma

  5.3 Neuroendocrine Tumors

  5.4 Hepatocellular Carcinoma

  5.5 Glioblastoma (Brain Tumor)

  5.6 Other Cancers/Tumors Where mTOR Inhibitors Could be Effective

    5.6.1 Non-small Cell Lung Cancers

    5.6.2 Colon Cancer

6. Recent Advances in mTOR Inhibitor Cancer Therapy

  6.1 Drug Combinations as a Therapeutic Approach for mTORC1 Inhibitors in Human Cancer

  6.2 Optimizing Activity of Rapalogs Using Combinations with Other Anticancer Drugs

7. Global Demand and Opportunities in the mTOR Inhibitor Market

8. Global andndash; Cancer MTOR Inhibitors Clinical Pipeline by Company, Indication and Phase

  8.1 Research

  8.2 Preclinical

  8.3 Phase-I

  8.4 Phase-I/II

  8.5 Phase-II

  8.6 Phase-III

9. Marketed Cancer MTOR Inhibitors Clinical Insight

  9.1 Temsirolimus (Torisel)

  9.2 Everolimus (Absorb, Affinitor, Affinitor Dispersible, Afinitor, Afinitor Disperz, Certican, Esprit BVS, Promus, Promus Element, Promus Premier, Synergy, Votubia, Xience Prime, Xience V, Xience Xpedition, Xience nano and Zortress)

10. mTOR Inhibitor andndash; Price Analysis by Under Development and Approved Inhibitors

  10.1 mTOR Inhibitors Price by Product Under Development

    10.1.1 Dactolisib(BEZ 235, NVP-BEZ 235)

    10.1.2 Rapamycin

    10.1.3 Temsirolimus

    10.1.4 PI-103

    10.1.5 AZD 8055

    10.1.6 Torkinib (pp242)

    10.1.7 Ridaforolimus (Deforolimus, MK-8669)

    10.1.8 MLN0128 (INK128)

    10.1.9 Omipalisib (GSK2126458, GSK458)

    10.1.10 Gedatolisib (PF-05212384, PKI-587)

    10.1.11 Other Promising mTOR Inhibitors

  10.2 Approved and Commercialized Cancer Therapy mTOR Inhibitor Price Analysis

    10.2.1 Afinitor/Votubia

    10.2.2 Afinitor Disperz andndash; mTOR inhibitor for Rare Pediatric Brain Tumor

    10.2.3 Torisel (Temsirolimus)

    10.2.4 Evertor andndash; Everolimus by Biocon

11. Market Performance Analysis of mTOR Inhibitors

  11.1 Market Performance by Industry

    11.1.1 Afinitor by Novartis

    11.1.2 Toricel by Pfizer

    11.1.3 Evertor by Biocon

12. Comparative Cost Analysis of mTOR Inhibitors with Other Cancer Therapeutics

  12.1 Comparative Cost Analysis by other Popular Cancer Therapy Drugs

  12.2 Comparative Cost Analysis with Traditional Cancer Therapeutics

13. Regional Analysis of mTOR Inhibitor Market

  13.1 North America

  13.2 Europe

  13.3 Asia Pacific

  13.4 Rest of the World

14. Global mTOR Inhibitor Market Dynamics

  14.1 Driving Factors of the Global mTOR Inhibitor Market

  14.2 Restraining Factors of the Global mTOR Inhibitor Market

15. Future Forecast and Growth Projections of Global mTOR Inhibitors Market

16. Competitive Landscape

  16.1 Abraxis BioScience

  16.2 Adimab

  16.3 Celgene Corporation

  16.4 Celator Pharmaceuticals

  16.5 Eli Lilly

  16.6 Exelixis

  16.7 GlaxoSmithKline

  16.8 HEC Pharm

  16.9 Intellikine

  16.10 Novartis

  16.11 Oneness Biotech

  16.12 PIQUR Therapeutics

  16.13 Semafore Pharmaceuticals

  16.14 Takeda

  16.15 Wyeth

 

Figure 1-1: mTOR Inhibitors Timeline

Figure 2-1: Normal Functioning of the mTOR Pathway

Figure 3-1: Activators of the mTOR Pathway

Figure 3-2: Global andndash; Cancer MTOR Inhibitors Clinical Pipeline by Phase (%), 2017 till 2022

Figure 3-3: Global andndash; Cancer MTOR Inhibitors Clinical Pipeline by Phase (Number), 2017 till 2022

Figure 3-4: Global andndash; Cancer MTOR Inhibitors Clinical Pipeline by Phase (%), 2017 till 2022

Figure 3-5: Global andndash; Cancer MTOR Inhibitors Clinical Pipeline by Phase (Number), 2017 till 2022

Figure 4-1: mTOR Inhibitors in Action

Figure 5-1: mTOR inhibitors in Breast Cancer

Figure 5-2: The mTOR (PAM) Pathway and Inhibitors of the pathway tested in phase I-III Clinical Trials on Solid Tumors and Breast Cancer

Figure 5-3: Action of Inhibitors under Clinical Development

Figure 6-1: Higher Efficacy of Therapeutics Achieved by using mTOR inhibitor in Combination

Figure 7-1: Global – Breast Cancer Incidence (Per 100,000 females), 2016

Figure 7-2: Global – Kidney Cancer Prevalence (Total Incidence Recorded), 2016

Figure 7-3: Global-Hepatocellular Carcinoma by Region ( per 100, 000),2016

Figure 10-1: Dactolisib- Price Analysis (US$/mg),2017

Figure 10-2: Rapamycin – Price Analysis (US$/mg), 2017

Figure 10-3: Temsirolimus – Price Analysis (US$/gm.), 2017

Figure 10-4: PI-103 Price Analysis (US$/gm.), 2017

Figure 10-5: AZD 8055-Price analysis (US$/mg), 2017

Figure 10-6: Torkinib-Price Analysis (US $/mg), 2017

Figure 10-7: Ridaforolimus- Price Analysis (US$/mg), 2017

Figure 10-8: MLNO 128- Price Analysis (US$/mg), 2017

Figure 10-9: Omipalisib – Price Analysis (US$/mg), 2017

Figure 10-10: Gedatolisib – Price Analysis (US$/mg), 2017

Figure 10-11: Apitolisib (GDC-0980, RG7422) – Price Analysis (US$/mg), 2017

Figure 10-12:  Vistusertib-(AZD2014 (GDC-0980, RG7422) – Price Analysis (US$/mg), 2017

Figure 10-13: Voxtalisib -AZD2014 (GDC-0980, RG7422) – Price Analysis (US$/mg), 2017

Figure 10-14: OSI-27 price analysis (US$/mg), 2017

Figure 10-15: US – Price Analysis of Afinitor by quantity (28 Tablet Packet), 2017

Figure 10-16: Price Analysis- Everolimus Standalone Therapy (US$), 2017

Figure 10-17: Afinitor Disperz – Price Analysis by Quantity (US$), 2017

Figure 10-18: Temsirolimus – Cost Analysis (US$), 2017

Figure 10-19: Cost Analysis andndash; Evertor (Everolimus by Biocon)(US$), 2017

Figure 11-1: Global andndash; Afinitor Sales (US$ Million), 2013-2016

Figure 11-2: Global – Toricel Sales (US$ Million), 2012-2016

Figure 11-3: Global andndash; Evertor Sales (US$ Million), 2012-2016

Figure 12-1: Comparative Cost Analysis andndash; Afinitor (mTOR inhibitor) v/s Other Recommended Therapy for Breast Cancer (US$/Month), 2017

Figure 12-2: Comparative Cost Analysis andndash; Everolimus and Temsirolimus (mTOR inhibitors) v/s Other Recommended Therapy for Kidney Cancer (US$/Month), 2017

Figure 12-3: Comparative Cost Analysis andndash; Average mTOR Inhibitor Therapy v/s Traditional Cancer Therapy Cost

Figure 13-1: Global- mTOR Inhibitor Market by Region (%), 2016 and 2022

Figure 14-1: Global – Driving Factors of the mTOR Inhibitor Market

Figure 14-2: Global – Challenging Factors of the Global mTOR Inhibitor Market

Figure 14-3: Afinitor – Patent Expiration, 2017-2020

 

 

 

Table 3-1: mTOR Overexpression and Related Tumors

Table 11-1: Asia- Leading Manufactures and Suppliers of Everolimus

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