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Duke University Heart Patch Shows Promise in Repairing Cardiac Tissue Damage

November 29th, 2017 Scott Jung Cardiac Surgery, Cardiology, Genetics

Researchers at Duke University have developed an artificially-engineered patch consisting of fully functional human heart muscle tissue that can be used to repair damaged areas of the heart. While it’s not the first cardiac tissue to be artificially engineered, it’s significant in that it’s the first that is large enough to be clinically useful to cover an affected area of the heart while being strong enough and as electrically active as native heart tissue.

The Duke heart patch is created similarly to other artificially-engineered cardiac tissues: human pluripotent stem cells are injected into a support structure and are supplied with nutrients and growth factors. Under specific conditions, the stem cells can differentiate into cardiomyocytes and other types of tissues found in the heart. Researchers were successful in growing a patch 2.5 square inches (16 square cm) and five to eight cells thick in size that resembled native cardiac tissue in structure and was fully functional both electrically and mechanically.

Moreover, after implanting the heart patches onto rat and mouse hearts, the researchers saw that the patches maintained their function and became vascularized and integrated with the heart’s native tissues.

Here’s a short video showing off the new heart patch:

Journal abstract in Nature Communications: Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues…

Via Duke: Beating Heart Patch is Large Enough to Repair the Human Heart…

Scott Jung

Scott Jung (@scottjung) is a Silicon Valley-based medical and health technology reporter and advocate, with a focus on wearables, telemedicine, and health technology in emerging countries. He has represented Medgadget at CES and Digital Health Summit, TEDMED, Stanford Medicine X, and SXSW. Always on the lookout for innovative medical technology worldwide, Scott has been invited to visit Colombia, Poland, and many other countries around the world to share how medtech is enriching the lives of its people. Scott holds a B.S. degree in Biomedical Engineering from the University of Southern California and an M.S. degree in Medical Product Development Management from San José State University. Scott is always looking for the next big thing in medical technology and digital health. Interested in helping him transform lives? Get in touch with him at http://scottju.ng

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