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Artificial Beta Cells Can Release Insulin On-Demand

November 2nd, 2017 Conn Hastings Medicine, Nanomedicine, Pediatrics

Fluorescence image of the artificial beta cells. (Gu Lab, UNC-NC State)

Researchers from the University of North Carolina and North Carolina State University have developed artificial beta cells that can release insulin in response to rising glucose levels in the blood stream. The technology could be used to treat diabetes through subcutaneous injections of the cells into patients, or gradual delivery using a skin patch.

The idea is that the cells could replace the repeated and painful insulin injections that patients with diabetes currently have to self-administer, by mimicking the beta cells in the pancreas. The research team wanted a solution that could control glucose levels in a more responsive and less invasive way.

The artificial cells are encased by a two-layered lipid membrane, just like a natural cell. However, they contain small vesicles packed with insulin. When levels of glucose in the blood increase, a chemical change in the vesicles causes them to fuse with the outer membrane of the artificial cell and release the insulin into the blood stream

False color Cryo-Scanning Electron Microscope image of the artificial beta cells. (Gu Lab, UNC-NC State)

Impressively, a single injection of the artificial cells into diabetic mice with no beta cells of their own, caused their blood glucose levels to rapidly normalize. “The mice went from hyperglycemic to normoglycemic within an hour, and they remained normoglycemic for up to five days after that,” said Zhen Gu, a researcher involved in the study.

The team has more animal tests planned and wants to develop a way to deliver the cells painlessly using a replaceable skin patch. “Our plan now is to further optimize and test these synthetic cells in larger animals, develop a skin patch delivery system for them, and ultimately test them in people with diabetes,” said Gu.

Study in Nature Chemical Biology: Synthetic beta cells for fusion-mediated dynamic insulin secretion…

Via: UNC…

Conn Hastings

Conn Hastings received a PhD from the Royal College of Surgeons in Ireland for his work in drug delivery, investigating the potential of injectable hydrogels to deliver cells, drugs and nanoparticles in the treatment of cancer and cardiovascular diseases. After achieving his PhD and completing a year of postdoctoral research, Conn pursued a career in academic publishing, before becoming a full-time science writer and editor, combining his experience within the biomedical sciences with his passion for written communication.

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