A DNA vaccine may enhance antibody response to the gene products and expand the applications of the gene vaccines.
According to a new report published by Allied Market Research, titled, Potential Analysis of Human DNA Vaccines Market by Forecast Scenario: Global Opportunity Analysis and Industry Forecast, 2020-2030, the global potential analysis of human DNA vaccines market is expected to account for $3,762 million by 2020 and reach $9,337 million by 2030, growing at a CAGR of 9.5% from 2020 to 2030. Key opportunities for market expansion include the high need for vaccines for immunization & prevention of infectious diseases.
High Prevalence of Diseases
DNA vaccine involves the administration of DNA components that stimulate protective immunity against a specific infectious agent. The demand for vaccines has increased significantly over the past few years, owing to high incidence of diseases worldwide. These vaccines are highly efficient in preventing infectious diseases, and hence offer opportunity for the market players. Introduction of DNA vaccines would facility eradication of diseases such as cancer, hepatitis, HIV, and others. In addition, vaccines are essentially recommended for travelers as they are at a high risk of exposure to various diseases.
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For instance, travelers are advised to be vaccinated against cholera, hepatitis, meningococcal diseases, Japanese encephalitis, typhoid fever, yellow fever, rabies, polio, and tick-borne encephalitis while traveling. The incidence of aforementioned diseases in selective travel destinations has increased the need for DNA vaccines across different geographies. Further, certain diseases require routine vaccinations, such as cholera; dengue; diphtheria, tetanus, pertussis (DTP), haemophilus influenza type B; hepatitis A; hepatitis B; and human papilloma virus. Furthermore, increase in incidence of pneumococcal diseases and influenza boosts the demand for DNA vaccines. In addition, DNA vaccines provide both humoral and cell-mediated immunity, thus having a wide application area.
The major selected clinical targets for DNA vaccines are influenza, human papillomavirus, and HIV. According to the World Health Organization, cervical cancer (caused due to HPV) is the third leading cause of death worldwide. Preventive HPV vaccines such as Gardasil (Merck) in 2006 and Cervarix (GlaxoSmithKline) in 2009 have been developed, but the impact of these vaccines is slow due to high economic burden and high incidence of HPV. Thus, DNA vaccines can provide strong cellular response, and hence provide faster immunization against HPV. Several DNA vaccine clinical trials have been recently completed or are currently ongoing, such as ZYC101 (Eisai Pharmaceuticals) has completed phase I trial. HPV-16 and HPV-18 E6/E7 are being evaluated in a phase I clinical trial (Inovio Pharmaceuticals).
The key players profiled in the report include Inovio Pharmaceuticals, Inc., GeneOne Life Science Inc., MedImmune, Immunomic Therapeutics, Inc., Astellas Pharma, Inc., Pharos Biologicals, Sanofi S.A., F. Hoffmann-La Roche AG, CureVac, and Boehringer Ingelheim GmbH.