NonAlcoholic Steatohepatitis Epidemiology Forecast to 2025 provide an overview of the risk factors and global trends of NASH in the 7MM (US, France, Germany, Italy, Spain, UK, and Japan). It includes a 10-year epidemiological forecast for the total prevalent cases (both diagnosed and undiagnosed) of NASH segmented by age and sex. It also includes a 10-year epidemiological forecast for the diagnosed prevalent cases of NASH, which are further segmented by comorbid disorders, including obesity, diabetes mellitus type 2 (T2D), hyperlipidemia, and hypertension in these markets.
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Non-alcoholic steatohepatitis (NASH) is a common, often clinically silent liver disease characterized by the presence of steatosis (fatty liver), in addition to liver inflammation and damage (NIDDK, 2014). Unlike alcoholic liver disease, NASH occurs in those who drink little or no alcohol. NASH usually presents with few or no symptoms, and most people affected with the disease feel healthy and are unaware they have a problem (NIDDK, 2014). However, symptoms including fatigue, weight loss, and weakness emerge once the disease has progressed to a more advanced stage, like cirrhosis. NASH is suspected if elevated liver enzymes are detected during routine blood panels, but it is only definitively diagnosed when a liver biopsy is performed (NIDDK, 2014). Both NASH and non-alcoholic fatty liver (NAFL) are histologically categorized under the umbrella of non-alcoholic fatty liver disease (NAFLD). NAFL is defined as the presence of a fatty liver with no evidence of hepatocellular injury or fibrosis, whereas NASH is defined as the presence of fatty liver and inflammation with evidence of hepatocyte injury (in the form of ballooning), with or without fibrosis.
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Epidemiologists forecast that the total prevalent cases of NASH in the 7MM will grow by 0.65% per year over the next 10 years, from 60,325,647 cases in 2015, to 64,273,379 cases in 2025. In the 7MM, the US will have the highest number of total prevalent cases throughout the forecast period, accounting for 56.85% of all total prevalent cases in the 7MM in 2015. When analyzing the individual markets, more than 85.00% of the total prevalent cases of NASH occurred in ages 20 years and older and more cases occurred in men compared with women.7MM will see an increase in the diagnosed prevalent cases of NASH from 16,952,459 cases in 2015 to 31,000,983 cases in 2025, at the rate of 8.29%. Diagnosed prevalent cases are forecast to increase faster than total prevalent cases due to expected increase in diagnosis rate, as indicated by primary research. Among the diagnosed prevalent cases of NASH, obesity is the most common comorbidity, where 78.68% of the NASH cases also are obese.
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List of Tables:
Table 1: Risk Factors and Comorbidities for NASH
Table 2: 7MM, Sources of Epidemiological Data Used to Forecast Total Prevalent Cases of NASH
Table 3: 7MM, Sources of Epidemiological Data Used to Forecast Diagnosed Prevalent Cases of NASH
Table 4: 7MM, Sources of Epidemiological Data Used to Forecast the Diagnosed Prevalent Cases of NASH by Comorbid Disorder
Table 5: 7MM, Total Prevalent Cases of NASH, Both Sexes, Ages? 4 Years, Select Years, 2015-2025
Table 6: 7MM, Age-Specific Total Prevalent Cases of NASH, Both Sexes, N (Row %), 2015
Table 7: 7MM, Sex-Specific Total Prevalent Cases of NASH, Ages? 4 Years, N (Row %), 2015
Table 8: 7MM, Diagnosed Prevalent Cases of NASH, Both Sexes, Ages? 4 Years, Select Years, 2015-2025
Table 9: 7MM, Diagnosed Prevalent Cases of NASH, by Comorbid Disorder, Ages? 4 Years, N (Row %), 2015
Table 10: High-Prescribing Physicians (non-KOLs) Surveyed, by Country
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