Zion Market Research has published a new report titled “Pyrogen Testing Market by Product (Instruments, Services, Kits, and Reagents) by test type (In Vitro, LAL, Rabbit) for Pharmaceutical & Biotechnology, Medical Devices and Other Application – Global Industry Perspective, Comprehensive Analysis and Forecast, 2015 – 2021”. According to the report, the global pyrogen testing market accounted for USD 564.4 Million in 2015 and is expected to reach USD 1,107.0 Million by 2021, growing at a CAGR of around 12.2% between 2016 and 2021.
Pyrogens comprise a diverse group of microbial and nonmicrobial substances which causes fever when directly injected into the human blood. In general, the human body is capable of fighting the bacterial toxins when it is exposed to the external environment through the skin. However, when these bacterial toxins enter the bloodstream via the parental route, they can cause the adverse reaction. The adverse effects of pyrogen include high fever, a rise in body temperature, chills, body aches, the rise in arterial blood pressure, and cutaneous vasoconstriction. The most potent and most widely known pyrogens are the endotoxins or lipopolysaccharides (LPS), which are cell wall components of gram-negative bacteria. However, small particles of packaging materials are a typical example of non-microbial pyrogens.
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Globally, a market of pyrogen testing has been driven by the latest development in pharmaceutical research across different parts of the world.In addition, growing number of new drug launches, rapid growth in pharmaceutical and biotechnology industry also serves as a driving factor for fueling the growth of pyrogen testing market. Furthermore, increasing R&D investment in life science drugs and the rise of government support to pharmaceutical and biotechnology industries are also considered as driving factors for the growth of pyrogen testing market. However, various limitations in the pharmaceutical industry are considered as a restraining factor which affects the growth of pyrogen testing market.Nonetheless, increasing marketing coupled with pharmaceutical outsourcing activities can serve as major opportunities for the global pyrogen testing market which is likely to increase the growth avenues of the market.
Based on product, pyrogen testing market is classified into three types: instruments, services, kits, and reagents. Kits and reagents were the dominating segments in 2015, in terms of market revenue followed by service and instrument.LAL test (Limulus Amebocyte Lysate test) kit is a cost effective way of detecting pyrogen more accurately followed by instruments.
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Based on the type of test, pyrogen testing market is classified into three types: in vitro test, LAL test, and rabbit test. LAL test dominated the pyrogen testing market in 2015 followed by rabbit test due to its various advantages over rabbit test. Limulus Amebocyte Lysate (LAL) test is a bacterial endotoxin test. This test is carried out on pharmaceutical product and other products such as blood products and plasma fractions, vaccines, nebulizers used in respiratory therapy, and for the validation of dry heat sterilization. However, LAL test is more advantageous than the rabbit pyrogen test as it is less time consuming, more sensitive, less expensive, and easier to perform.One of the main advantages of the LAL test is that the horseshoe crab remains alive even after extraction of hemolymph which is used in the preparation of LAL reagent.
Based on application, pyrogen testing market is classified into three type pharmaceutical & biotechnology, medical device, and other application. Pharmaceutical and biotechnology segment dominated the pyrogen testing market in terms of market revenue due to its wide application in pharmaceutical industry. In addition, increasing R&D investments in life science drugs coupled with government support are likely to increase the growth avenue of the market within the forecast period.For instance, the number of new biologics products launched annually witnessed a strong upward trend between 2005 and 2014. The number of new products launched in 2013 was approximately 54 as compared to 25 in 2003. The biologics pipeline has increased by above 150%, from approximately 328 treatments in 2001 to 867 in 2012. A strong pharmaceutical product pipeline will aid the growth of the pharmaceutical and biotechnology industry, which is an important application of pyrogen testing products.
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The major players in the pyrogen testing market include Associates of Cape Cod, Inc., Charles River Laboratories, Inc., Ellab A/S, Genscript, Hyglos GmbH, Lonza Group, Merck Kgaa, Thermo Fisher Scientific, Inc., WUXI Pharmatech (Cayman) Inc. and Wako Chemicals Usa, Inc.
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