Psoriatic Arthritis is a type of chronic inflammatory arthritis that primarily affects toes and fingers followed by nail or skin psoriasis. The clinical features are varied but the major symptoms are peripheral arthritis, enthesitis, psoriasis, dactylitis and axial disease. According to Arthritis Foundation, the prevalence of psoriatic arthritis in patients suffering from psoriasis is approximately between 7% and 48%. Psoriatic arthritis appears most often between the age of 30 years and 50 years. The factors contributing to the pathogenesis of psoriatic arthritis are genetic factors, environmental factors and immunological factors.
Genetic factors explain that 40% of the psoriatic arthritis has family history of skin and joint diseases. Environmental factors such as bacterial and viral infections have been implicated as a cause in psoriatic arthritis. Immunological factors consist of cytokines such as TNF-α which is critically involved in inflammatory process, leading to bone and cartilage degradation as well as skin inflammation. There are five different types of psoriatic arthritis that includes different joints and spinal column. There are two types of method by which psoriatic arthritis is diagnosed by imaging and laboratory test. Imaging tests consist of X-Rays and magnetic resonance imaging and laboratories consists of rheumatoid factor and joint fluid test.
The pharmacotherapy of psoriatic arthritis consists of drugs such as DMARDs (disease modifying anti-rheumatic drugs), NSAIDs, Immunosuppressant and TNF-α inhibitors. In chronic conditions surgeries and other procedures are practiced such as steroid injections and joint replacement surgery. The DMARDs consists of drug that reduces the progression of psoriatic arthritis and protect joints and other tissues from irreversible damage, it includes drugs such as methotrexate, sulfasalazine and leflunomide. The NSAIDs help to relive the pain and reduction of inflammation and most of them are OTC drugs including Ibuprofen and naproxen sodium. While immunosuppressant helps to control the immune system including azathioprine and cyclosporine. TNF-α inhibitors assist reducing pain, swollen joints and morning stiffness this class of drug includes etanercept, infliximab, adalimumab, Humira, certolizumab and golimumab.
Some of the major factors driving the psoriatic arthritis market are rising geriatric population, increasing incidences of psoriatic arthritis and major onset for growth in this market is expected from the launch of blockbuster drugs such as Simponi and Vicodin along with many impending biologics that are in late stage of development. The major factors restraining the growth of psoriatic arthritis pharmacotherapy market are the new biologics that are observed to be highly efficient but come with high cost. Lack of patient awareness is one of the major factor affecting the growth of psoriatic arthritis pharmacotherapy market according to CDC (Center of Disease Control and Prevention) nearly 10% – 12% of the patients visit clinics during the chronic stage of psoriatic arthritis as most of them ignore initial symptoms which are very common like skin reddening along with a joint pain or a skin rash.
North America was observed to be the leading geography due to high prevalence of psoriatic arthritis followed by availability of modern healthcare facilities is assisting the growth of this market. Europe is the second largest market for psoriatic arthritis pharmacotherapy as it’s the region expected to observe rapid aging population. Asia-Pacific and Rest of the World are the most attractive and growing markets in psoriatic arthritis pharmacotherapy. In Asia-Pacific China, India, Japan, South Korea and Australia are observed to be the leading geographies in psoriatic arthritis.
The psoriatic arthritis pharmacotherapy market is predominantly led by the players such as Pfizer, Inc., Amgen, Inc., Merck & Co, Inc., F. Hoffmann-La Roche Ltd, Johnson & Johnson, Abbott Laboratories and Novartis International AG. It was observed that Abbott Laboratories, Johnson and Johnson and Amgen, Inc. account for the major market share in psoriatic arthritis pharmacotherapy.
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