Protein expression, purification and large scale production is achieved by manipulation in the gene expression process of an organism such that it is able to express large amounts of a recombinant gene. It is not a trivial task and faces a huge competition in the market because of the fragmented scenario over the globe. Fermenters and bioreactors with different expression system capabilities, purity options, quality control and the production timeline differentiate various services available in the market. Various organizations have developed their own in-house methods of production and purification. Bacterial and yeast systems are mostly used in case of microbial protein production process because of simple physiology, short generation times and high yield of product, both having their own advantages and disadvantages. Among bacterial, E. coli has been most widely used for recombinant protein expression and production. Clients can use the service for the manufacture of either the regular proteins whose gene sequence is available in the public domain or can manufacture its customized gene expression
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Producing recombinant proteins is often the limiting and most expensive step in life science research. Expression yield of recombinant proteins vary by orders of magnitudes from protein to protein reflecting the difference in the cost of production process. These services are more preferred due to the increasing customization in the genetic sequences. Microbial protein production services also involves the use of various types of tags for purification purposes such as FLAG-tag, His-tag, Fc-fusion tag, GST-tag, Myc-tag, HA-tag, MBP-tag and others.
Microbial Protein Production Services Market: Drivers & Restraints
Increase in the number of applications of microbial proteins such as the increasing enzymatic applications and their requirement in various industries, increase in the production of bio-pharmaceuticals like monoclonal antibodies, hepatitis B vaccine and HPV vaccine are increasing the need of microbial protein production services to meet the demand. Recent advances in proteomics and rapid growth in protein drug market also constantly increasing the market of pure and active proteins. Increasing number of CROs also fuels the services market. One of the limiting factor for the growth is not possessing the same capability as eukaryotic cells for protein glycosylation and other post-translational modifications and thus limits its applications. Increasing regulatory pressure on CROs, high cost involved, lack of skilled manpopwer, infrastructure and skilled expertise may also restricts the growth.
Microbial Protein Production Services Market: Segmentation
By Production Type:
- Bacterial Protein Expression
- Yeast Protein Expression
- Other microbial protein expression
By Service Type:
- Customized Production
- Regular Production
By End User:
- Pharmaceutical Industry
- Biotechnology Companies
- Food and Feed Industry
- Research Organizations
- Academic Institutes
- North America
- Latin America
- Middle East and Africa
Microbial protein production services constitutes of companies and research organizations engaged in protein production and purification services. Bio therapeutic protein and vaccine manufacturers faces various challenges related to time and cost in the drug discovery and development process. The service units take only the protein sequence and adjust the amount and purity required for protein production. These type of services help in saving time and cost to accomplish the research needs. Competitive prices of different products and the quality differentiates the market players. Continuous innovations and improvements in the protein expression systems are the need of the market. Various mergers and partnership deals in this sector also fuels the market such as Ewos recently offered a US $30 million funding package to Calysta which is planning to manufacture novel high quality microbial proteins for the fish feed industry in the UK.
geographic condition regarding the Microbial Protein Production Services Market, it has been segmented into five key regions: North America, Latin America, Europe, Asia-Pacific and the Middle East & Africa. With large number of research organizations and usage in number of applications in various industries, North America depicts an established market for these services. Extensive competition is faced by the European countries because of the excellent number of contract research organizations and established network of universities and research institutions in the region. Asia Pacific is the growing market because of establishment of more biotechnological and pharmaceutical industries and opening of more contract research organizations. Moreover, low cost manufacturing also attracts the market in this region.
Some of the market players in the microbial protein production service market includes Wacker, Chemie AG, Icosagen, Sino Biological, GenScript, LP3 Labs, Lonza, Biomatik, GenWay Biotech, Inc., Olympic Protein Technologies, Amid Biosciences and many others.
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