Vasomotor symptoms occur when a woman reach the state of menopause and ovaries stop producing eggs, and there is a reduction in secretion of hormones such as estrogen and progesterone. It usually occurs naturally, most often between age of 45 years to 51 years. The women feel perimenopausal transition that generally occurs prior to cessation of menstruation. During perimenopausal transition, the menstruation cycle becomes erratic, leading to irregular menses, heavy bleeding, hot flashes and dryness of vagina. Decline in circulating estrogen level represents clinical symptoms of menopause that occurs after cessation of ovarian follicular function. The most common symptom of vasomotor menopause is hot flashes and hormone therapy is the most effective therapy for hot flashes. From many years, hot flashes have been treated with either oral or transdermal forms of estrogen alone or in combination with progesterone.
The vasomotor symptoms of menopause therapeutics have more than 20 drugs. In pipeline analysis, drugs are analyzed on the basis of route of administration and molecule type. The pipeline is also analyzed on the basis of monotherapy and combination therapy, and different clinical phases including Phase III, Phase II, Phase I and Pre-Clinical stage.
HBN-2, a preclinical drug candidate of Hibernaid Inc., is being developed to minimize menopausal related hot-flashes or vasomotor symptoms of menopause, progeria and mild concussion. Preclinical study is also known as animal study. It is done before testing a drug in people to find out the toxicity profile of the drug. Preclinical study is of two types, including In vitro and In vivo.
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Pipeline analysis provides description about the key companies developing vasomotor symptoms of menopause drugs. Some of the key players actively involved in the research and development are TherapeuticsMD, Inc., Ogeda SA, NeRRe Therapeutics Ltd., Radius Health, Inc. and Pherin Pharmaceuticals, Inc.
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