The US Food and Drug Administration (FDA) has licensed a new vaccine for cholera for the usage in travelers. It has been available since 1990s though cholera is scarce in the U.S. travelers. Centers for Disease Control and Prevention (CDC) also recommended travelling adults to certain areas to get vaccinated. The vaccine has not yet currently licensed for children. A study has been conducted in cholera patients in United States which states that 80% of the infections were associated with international travel. Over the past decade, 90 cases were associated with cholera infection.
These patients reported that they travelled to Asia, Africa, and the Caribbean. The most unlikely reason for travel was meeting friends, followed by medical missions, work, tourism, and other relief work. FDA has given a set of recommendations for travelers to prevent cholera. Patients vising cholera-affected areas should eat food that is cooked and served hot. In addition, emphasis should be given to careful hand hygiene.
Vaxchora, a single-dose oral cholera vaccine is recommended for people aged between 18 and 64 years, who travel to certain areas of active transmission of toxigenic Vibrio cholerae O1. According to clinical trials, Vaxchora has reduced the risk of diarrhea after cholera by 90% at 10 days of vaccination. In addition, it reduced risk of 80% at 3 months following vaccination. Researchers have not found the effect of the vaccine beyond 6 months following vaccination. It is necessary to administrate vaccine at least 10 days prior to potential exposure to cholera.
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In clinical trials, Vaxchora reduced the risk for severe diarrhea after a cholera challenge by 90% at 10 days after vaccination, and by 80% at 3 months after vaccination. The duration of protection of Vaxchora beyond 3-6 months is not known at this time. The vaccine should be administered at least 10 days before potential exposure to cholera. Adverse reactions seemed uncommon in clinical trials, whereas included headache, fatigue, nausea, abdominal pain, vomiting, and diarrhea. The vaccination is necessary for travelers with higher risk to low outcomes or cholera.
Even following vaccination, travelers need to take food and water precautions. Medical professionals need to discuss risk factors of poor outcomes if infected and the time at which professional help to be sought. Cholera can prove fatal in certain cases with travelers though it is rare in the U.S. The rehydration can be started as soon as possible following infection. Prevention strategies such as careful hand hygiene, safe food & water precautions, and vaccination. Particularly, vaccination is recommended for adults prone to transmission of cholera while travelling.
In its recent report that outlines global travelers’ vaccines market in top countries, Big Market Research offers insights on sales, revenue, and market share of leading countries. In addition, top manufacturers are discussed along with their market share in those countries. The report is a helpful source of information for market players and investors to determine emerging markets and gain competitive advantage.
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