Hepcidin is a small peptide which acts as iron regulatory hormone. The name ‘hepcidin’ is taken from the place of synthesis in hepatocytes (hep), whereas cidin denotes its antimicrobial activity. Liver is the key organ that secrete hepcidin and regulates iron hormone. Hepcidin was initially observed in human urine sample and in human blood ultrafiltrate as a small bactericidal peptide (defensin and cathelicidin) and now it is known as liver–expressed antimicrobial peptide. Hepcidin is encoded by HAMP, 19q13 gene, which is expressed in the liver, heart, lungs, brain, spinal cord, intestine, macrophages and several other organs. The mode of action of hepcidin activity depends on the interaction between hepcidin and ferroportin. Ferroportin is expressed on the surface of reticulo-endothelial macrophages, hepatocytes, duodenal enterocytes and placenta cells. It is the only known mammalian cellular iron exporter. Binding of Hepcidin with ferroportin causes its internalization and degradation in endo lysosomes, which in turn blocks the iron transport through ferroportin.
The hepcidin antagonist pipeline has more than 10 drugs. In pipeline analysis, drugs are analyzed on the basis of route of administration and molecule type. The pipeline is also analyzed on the basis of monotherapy and combination therapy, and different clinical phases including Phase III, Phase II, Phase I and Pre-clinical stage.
ABT-207, a pre-clinical drug candidate of AbbVie Inc. is being developed for the treatment of anemia of inflammation. ABT-207 is a humanized antibody that inhibits repulsive guidance molecule C and thus downregulate hepcidin. Pre-clinical study is also known as animal study. It is done before testing a drug in people to find out the toxicity profile of the drug. Pre-Clinical study is of two types, including In vitro and In vivo.
Request for Table of Content at: https://www.psmarketresearch.com/market-analysis/hepcidin-antagonist-pipeline-analysis/toc-sample
Pipeline analysis provides description about the key companies developing hepcidin antagonist drugs. Some of the key players actively involved in the research and development are Celgene Corporation, Akebia Therapeutics, Inc., FibroGen, Inc., Noxxon Pharma AG and Tolero Pharmaceuticals, Inc.
About P&S Market Research
P&S Market Research is a market research company, which offers market research and consulting services for various geographies around the globe. We provide market research reports, industry forecasting reports, business intelligence, and research based consulting services across different industry/business verticals.
As one of the top growing market research agency, we’re keen upon providing market landscape and accurate forecasting. Our analysts and consultants are proficient with business intelligence and market analysis, through their interaction with leading companies of the concerned domain. We help our clients with B2B market research and assist them in identifying various windows of opportunity, and framing informed and customized business expansion strategies in different regions.
Manager – Client Partner
347, 5th Ave. #1402
New York City, NY – 10016
Toll-free: +1-888-778-7886 (USA/Canada)