The prostate cancer generally shows the symptoms as that of benign prostate hyperplasia (BPH) which makes its detection a major problem. The medical experts claim that conventional screening of prostate cancer can now no longer differentiate between benign conditions and aggressive cancer. Doctors with the U.S. Preventive Service Task argue that older version to screen PSA comes with dangers. The doctors have been using the PSA test since early 1990s and they feel that with new researches conducted in area of the prostate cancer diagnostics, better treatments should be provided to the patients.
Recently, Sophiris Bio Inc., (SPHS) announced to develop a new therapeutic intervention for detection of BPH’s symptoms. The firm’s leading product, topsalysin (PRX302) is an inherently engineered recombinant protein which is stimulated by PSA through enzymatic cleavage. The PSA is produced in huge quantities by the prostate gland. Once it gets triggered, topsalysin associates with its alternative molecules to produce stable transmembrane pores which causes cell to die. The compound has been positively tested in a Phase 2a clinical treatment with localized prostate cancer and Phase 3 clinical intervention for BPH.
It has been observed by the medical experts that there is an urgent need to shift from the conventional treatment methods. It was reported by the patients of the prostate cancer that they often face a dizzying quandary before opting for screening method. A recent study conducted by Dr. Daniel Barocas highlights the problem faced by male patients before they choose the screening test. The research offers an analysis of side effects of treatments which provides clarity to the patients.
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The study supports evidences in which it was found that urinary incontinence and sexual problems are common phenomenon after surgery than radiation. It also expresses differences in quality of life which tends to decrease with time for the patients whose cancer did not spread. This type of cancer is common in males. Dr. Daniel Barocas of Vanderbilt University, states that men who elect observation could have problems related to enlarged prostates, including frequent urination in comparison to those who have surgery don’t face. The study aids the patients by providing them a road map which clears their doubts about the treatment. The studies provide answers, showing quality of life outcomes depends on treatment but also on men’s sexual and urinary function before diagnosis.
It has been estimated by the American Cancer Society that there would be approximately 160,000 new cases of prostate cancer in the U.S. and 26,000 deaths in 2017.
Patients of both studies, opted for new types of therapeutic interventions for the screening of the disease. They chose robotic surgery which makes small cuts to remove the prostate. The patients who opted for the external precision radiation noticed that it supports extra surroundings of the tissue which has cancer. The results of the research conclude with the side effects of older options. It states that urinary incontinence and persistent impotence are frequent symptoms observed by the patients after surgery. In addition, it was seen that both types of radiation produced more urinary problems for small duration and males who opted for external radiation testified that they had more bowel problems for short time. The research involved 3,700 male patients who were in their 60s on average during diagnosis.
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