Non-alcoholic Steatohepatitis (NASH) is a silent syndrome which originates in patients who are not alcoholic. It is one of a kind of fatty liver disease that primarily affects individuals with obesity, dyslipidemia and diabetes. In other words, NASH is a degenerative form of non-alcoholic fatty liver disease (NAFLD) which results in damage and inflammation of the liver with due course of time. The disease causes damage to the liver which is undistinguishable from alcoholic hepatitis. Even though the pathogenesis is weakly determined, however it appears to have been associated with insulin resistance, for instance, metabolic syndrome and obesity. Most of the patients having non-alcoholic Steatohepatitis show no peculiar symptoms. Nevertheless, laboratory based findings comprise of escalated levels of aminotransferase. Additional biopsy is needed to confirm and conclude the diagnosis. NASH treatments consists of getting rid of causes and several risk factors.The key cause for this disease is the excess unwanted deposition of fat in the liver. In case ignored and not treated on time, this disease could result in liver cirrhosis and eventually advance to liver failure. Research done on Non-alcoholic Steatohepatitis (NASH) market states that this disease’s prevalence across the world is alarmingly escalating particularly in the Western nations. It has been found that in the United States, NASH is the most common form of chronic liver disease that is affecting approximately 80 to 100 million people.Non-alcoholic fatty liver disease occurs is any given age group, however, in individuals who are in their mid-40s and are at greater risk of cardiac disease owing to such dangers such as type 2 diabetes and obesity.
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Pathophysiology of NASH
It comprises of fat build-up, i.e., steatosis, inflammation and uneven fibrosis. Steatosis is a resultant of accumulation of hepatic triglyceride. Potential mechanisms for steatosis cloaks decreased synthesis of very low density lipoprotein (VLDL) and escalated hepatic triglyceride synthesis. Lipid peroxidative damage to the cell membranes might lead to inflammation. All of these alterations can regulate hepatic stellate cells, which results in fibrosis. When NASH reaches the advanced stages, it can lead to portal hypertension and cirrhosis.
As already mentioned, most patients do not show any symptoms. But, a few possess malaise, extreme fatigue, and discomfort in the upper right quadrant.In 75 percent of the patients, hepatomegaly is developed. In case of the existence of hepatic fibrosis, splenomegaly generally is the initial sign that portal hypertension has developed.
- Past history, i.e., any inherited risk factors, no excess alcohol intake
- Serologic tests to eliminate possibilities of hepatitis B and C
- Liver biopsy
NASH treatments include managing the conditions which rise the risk of this disease or worsen it. One can:
- Discontinue certain drugs or toxins
- Decrease the Cholesterol level
- Control diabetes
- Maintain healthy weight
- Exercise regularly
Primary evidences indicate that vitamin E and thiazolidinediones might help in correcting the histological and biochemical abnormalities in NASH. Several other treatments such as metronidazole, ursodeoxycholic acid, glutamine infusion, metformin, glucagon, and betaine, and not quite proved to be efficient and effective in managing NASH conditions.
Table Of Content:
Global Nonalcoholic Steatohepatitis (NASH) Market Research Report 2017
1 Nonalcoholic Steatohepatitis (NASH) Market Overview
1.1 Product Overview and Scope of Nonalcoholic Steatohepatitis (NASH)
1.2 Nonalcoholic Steatohepatitis (NASH) Segment by Type
1.2.1 Global Production Market Share of Nonalcoholic Steatohepatitis (NASH) by Type in 2015
1.2.2 Weight Loss Treatment
1.2.3 Insulin-Sensitizing Agents
1.2.4 Lipid-Lowering Drugs
1.2.6 Other Agents
1.3 Nonalcoholic Steatohepatitis (NASH) Segment by Application
1.3.1 Nonalcoholic Steatohepatitis (NASH) Consumption Market Share by Application in 2015
1.3.2 Phase I
1.3.3 Phase II
1.3.4 Phase III
1.3.5 Clinical Trials
13 Research Findings and Conclusion
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